Kei Iida

Profile Information

Affiliation: Lecturer, Faculty of Science and Engineering, Kindai University
: Graduate School of Medicine, Kyoto University
: (Concurrent)Visiting Researcher, Graduate School of Medicine

Degree: Ph. D(Nagoya University)

ORCID ID: https://orcid.org/0000-0001-7130-8705
J-GLOBAL ID: 200901087903479252
researchmap Member ID: 5000076637

External link: https://keiiida.github.io/

Research Interests

Research Areas

Life sciences / Systems genomics / データサイエンス

Research History

Apr, 2024 - Present

Center for Cancer Immunotherapy and Immunobiology（CCII）, Kyoto University
Apr, 2022 - Present

Visiting Researcher, Graduate School of Medicine, Kyoto University
Apr, 2022 - Present

Lecturer, Faculty of Science and Engineering, Kindai University
Jun, 2022 - Mar, 2024

研究員(非常勤), 京都大学 iPS細胞研究所
Sep, 2012 - Mar, 2022

Research Assistant Professor, Graduate School of Medicine, Kyoto University
Dec, 2008 - Aug, 2012

BASE, RIKEN
Apr, 2007 - Nov, 2008

University of California, Riverside
Apr, 2004 - Mar, 2007

Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology
Apr, 2002 - Mar, 2004

ゲノム科学研究センター, 理化学研究所

Major Papers

CCL21‐Ser expression in melanoma cells recruits CCR7+ naïve T cells to tumor tissues and promotes tumor growth

Megumi Miyamoto, Yuki Kawato, Ryonosuke Fujie, Kaoru Kurowarabe, Kakeru Fujiwara, Reika Nobusawa, Ryota Hayashi, Kei Iida, Izumi Ohigashi, Haruko Hayasaka

Cancer Science, Jul 8, 2023 Peer-reviewed
Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease

Jiandong Yang, Yoshikazu Hirai, Kei Iida, Shinji Ito, Marika Trumm, Shiho Terada, Risako Sakai, Toshiyuki Tsuchiya, Osamu Tabata, Ken-ichiro Kamei

Communications Biology, 6(1), Mar 23, 2023 Peer-reviewed
Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer

Shingo Matsushima, Masahiko Ajiro, Kei Iida, Kenji Chamoto, Tasuku Honjo, Masatoshi Hagiwara

Science Translational Medicine, 14(673), Nov 30, 2022
Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ

Kei Iida, Masatoshi Hagiwara, Akihide Takeuchi

iScience, 23(7) 101325-101325, Jul, 2020 Peer-reviewed
Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts

Daria Merkurjev, Wan-Ting Hong, Kei Iida, Ikumi Oomoto, Belinda J. Goldie, Hitoshi Yamaguti, Takayuki Ohara, Shin-ya Kawaguchi, Tomoo Hirano, Kelsey C. Martin …

Nature Neuroscience, 1-11, Jun 27, 2018 Peer-reviewed
SINC-seq: correlation of transient gene expressions between nucleus and cytoplasm reflects single-cell physiology.

Abdelmoez MN, Iida K, Oguchi Y, Nishikii H, Yokokawa R, Kotera H, Uemura S, Santiago JG, Shintaku H

Genome biology, 19(1) 66-66, Jun, 2018 Peer-reviewed
Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain.

Akihide Takeuchi, Kei Iida, Toshiaki Tsubota, Motoyasu Hosokawa, Masatsugu Denawa, J B Brown, Kensuke Ninomiya, Mikako Ito, Hiroshi Kimura, Takaya Abe …

Cell reports, 23(5) 1326-1341, May 1, 2018 Peer-reviewed
Deciphering targeting rules of splicing modulator compounds: Case of TG003

Maki Sakuma, Kei Iida, Masatoshi Hagiwara

BMC Molecular Biology, 16(1), Sep 24, 2015 Peer-reviewed
A promoter-level mammalian expression atlas.

Alistair R R Forrest, Hideya Kawaji, Michael Rehli, J Kenneth Baillie, Michiel J L de Hoon, Vanja Haberle, Timo Lassmann, Ivan V Kulakovskiy, Marina Lizio, Masayoshi Itoh …

Nature, 507(7493) 462-70, Mar 27, 2014 Peer-reviewed
Bioinformatics analysis suggests base modifications of tRNAs and miRNAs in Arabidopsis thaliana

Kei Iida, Hailing Jin, Jian-Kang Zhu

BMC Genomics, 10(1) 155-155, Apr 9, 2009 Peer-reviewed
ROS3 is an RNA-binding protein required for DNA demethylation in Arabidopsis

Xianwu Zheng, Olga Pontes, Jianhua Zhu, Daisuke Miki, Fei Zhang, Wen-Xue Li, Kei Iida, Avnish Kapoor, Craig S. Pikaard, Jian-Kang Zhu

Nature, 455(7217) 1259-1262, Oct, 2008 Peer-reviewed
Survey of conserved alternative splicing events of mRNAs encoding SR proteins in land plants

K Iida, M Go

MOLECULAR BIOLOGY AND EVOLUTION, 23(5) 1085-1094, May, 2006 Peer-reviewed
Genome-wide analysis of alternative pre-mRNA splicing in Arabidopsis thaliana based on full-length cDNA sequences

K Iida, M Seki, T Sakurai, M Satou, K Akiyama, T Toyoda, A Konagaya, K Shinozaki

NUCLEIC ACIDS RESEARCH, 32(17) 5096-5103, 2004 Peer-reviewed
Empirical analysis of transcriptional activity in the Arabidopsis genome

K Yamada, J Lim, JM Dale, HM Chen, P Shinn, CJ Palm, AM Southwick, HC Wu, C Kim, M Nguyen …

SCIENCE, 302(5646) 842-846, Oct, 2003 Peer-reviewed

Misc.

Author Correction: Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.

Masahiko Ajiro, Tomonari Awaya, Young Jin Kim, Kei Iida, Masatsugu Denawa, Nobuo Tanaka, Ryo Kurosawa, Shingo Matsushima, Saiko Shibata, Tetsunori Sakamoto …

Nature communications, 12(1) 6039-6039, Oct 12, 2021
Dicer切断反応産物の次世代シークエンス解析を利用した低分子化合物の標的RNA配列モチーフの網羅的探索

村田亜沙子, 高島裕介, 飯田慶, 須貝亜矢子, 萩原正敏, 中谷和彦

日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020
Monitoring transcriptomic changes in soil-grown roots and shoots of Arabidopsis thaliana subjected to a progressive drought stress

Khurram Bashir, Sultana Rasheed, Akihiro Matsui, Kei Iida, Maho Tanaka, Motoaki Seki

Methods in Molecular Biology, 1761 223-230, 2018 Peer-reviewed
DNAメチル化亢進によるPITX1遺伝子発現抑制は食道扁平上皮癌の予後不良と関連する

河村由紀, 大坪武史, 山田和彦, 萩原輝記, 大島健志朗, 飯田慶, 西方公郎, 豊田哲郎, 猪狩亨, 野原京子 …

生命科学系学会合同年次大会, 2017年度 [1P-1004], Dec, 2017
がん細胞の代謝がもたらす組織微小環境を標的にしたがん治療

豊本雅靖, 井上飛鳥, 飯田慶, 出縄政嗣, 喜井勲, 林佳子, 岸貴之, 小野木博, 吉田優, 細谷孝充 …

生命科学系学会合同年次大会, 2017年度 [3AT25-1419)], Dec, 2017
食道癌のメチロームおよびトランスクリプトーム統合解析により見出されたホメオボックス遺伝子の発現低下

河村由紀, 大坪武史, 山田和彦, 萩原輝記, 大島健志朗, 飯田慶, 西方公郎, 豊田哲郎, 猪狩亨, 山田純 …

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [2P1114]-[2P1114], Dec, 2015
抗C型肝炎ウイルス能をもつ低分子化合物の同定

奥野友紀子, NGUYEN Bao Ngoc, NGUYEN Bao Ngoc, 飯田慶, 出縄政嗣, 坂本直哉, 影近弘之, 萩原正敏

日本ウイルス学会学術集会プログラム・抄録集, 61st, 2013
筋ジストロフィーに対するトランスレーショナル・リサーチ I.エクソン・スキップジストロフィンpre-mRNAのスプライシングを変化させる低分子化合物の探索

萩原正敏, 松尾雅文, 片岡直行, 飯田慶, 西田篤史

筋ジストロフィーに対するトランスレーショナル・リサーチ平成22-24年度総括研究報告書, 2013
筋ジストロフィーに対するトランスクリプトーム創薬の試み

飯田慶, 飯田慶, 片岡直行, 西田篤史, 川口修治, 豊田哲郎, 古野正朗, 松尾雅文, 林崎良英, 萩原正敏

日本RNA学会年会要旨集, 15th, 2013
シロイヌナズナ完全長cDNAエンサイクロペディアの作製と遺伝子の機能・発現解析への利用.

関原明, 佐藤将一, 石田順子, 櫻井哲也, 中嶋舞子, 秋山顕治, 槐亜希子, 飯田慶, 篠崎一雄

ゲノミクス・プロテオミクスの新展開（今中忠行監修）. 株式会社エヌ・ティー・エス., 328-336, 2004
Arabidopsis Encyclopedia using Full-length cDNAs and its Application for Functional Genomics

Seki Motoaki, Narusaka Mari, Oono Youko, Fujita Miki, Mizukado Saho, Nanjo Tokihiko, Umezawa Taishi, Kamei Ayako, To Taiko, Yamaguchi-Shinozaki Kazuko …

Plant and Cell Physiology Supplement, 2003 86-86, 2003
シロイヌナズナ完全長cDNAを用いた植物ゲノムの機能・発現解析.

関原明, 佐藤将一, 石田順子, 櫻井哲也, 中嶋舞子, 秋山顕治, 槐亜希子, 飯田慶, 大野陽子, 篠崎一雄

蛋白質核酸酵素, 48(14) 1890-1898, 2003

Professional Memberships

Dec, 2019 - Present

Japanese Association for Medical Artificial Intelligence
日本RNA学会

Research Projects

Construction of in vitro human liver disease model capable of real-time temperature mapping and its application to elucidation of disease mechanisms

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2027
Mechanisms of supporting cell reprogramming for inducing hair cell regeneration in chick basilar papillae

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
Elucidation of splicing-code with RNA-specialized machine learning system toward overcoming hereditary diseases having splicing misregulations

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Mechanisms for the initial process of hair cell regeneration in avian inner ears

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Deciphering neuroepigenetics that regulate the neural differentiation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022
Widely spread RNA modification at neuronal synapses add functional diversity to local transcriptome

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Wang Dan Ohtan
Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal Models

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S), Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2015 - Mar, 2020

Hagiwara Masatoshi
Computational studies for molecular mechanism of splicing- modulators upon comparative transcriptome analysis

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

IIDA Kei, Sakuma Maki
トランスクリプトームの人為的操作による遺伝病の治療

科学研究費助成事業基盤研究(A), 基盤研究(A), 日本学術振興会, Apr, 2015 - Mar, 2016

萩原正敏, 武内章英, 大江賢治, 二宮賢介, 飯田慶, 奥野友紀子
Splicing mechanisms of a novel split intron and evolution of the mRNA maturation process in eukaryotes

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

HASHIMOTO Tetsuo, INAGAKI Yuji, NARA Takeshi, IIDA Kei

Media Coverage

RNAスプライシング制御による新規がん免疫療法―ネオ抗原を産生増強する治療薬候補の同定―

京都大学, Dec, 2022 Internet
RNA結合タンパク質の標的分子探索手法を開発－複雑なRNA制御のメカニズム解明に期待－

京都大学, Jul, 2020 Internet
神経ネットワークの可塑性を支えるRNAの機能に即した化学修飾を明らかにしました

京都大学, Jul, 2018 Internet
1細胞RNA分画解読法の開発に成功

理化学研究所, Jun, 2018 Internet
神経巨大遺伝子の発現制御メカニズムの発見

京都大学, May, 2018 Internet
植物の新しい環境ストレス適応機構の発見

京都大学, Aug, 2017
次世代シーケンサーのデータ解析精度を向上させる新手法を開発

理化学研究所, Feb, 2012 Internet

Profile Information

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Research Areas

Research History

Major Papers

Misc.

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