2007年6月
Enzymatic synthesis of beta-lactam antibiotics and N-fatty-acylated amino compounds by the acyl-transfer reaction catalyzed by penicillin V acylase from Streptomyces mobaraensis
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
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- 巻
- 71
- 号
- 6
- 開始ページ
- 1582
- 終了ページ
- 1586
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1271/bbb.70052
- 出版者・発行元
- TAYLOR & FRANCIS LTD
Penicillin V acylase from Streptomyces mobaraensis (Sm-PVA) showed high acyl-transfer activity in reactions using methyl esters of carboxylic acid (acyl donor) and amino compounds (nucleophile), to produce the corresponding amides. Moreover, Sm-PVA had broad substrate specificity, as indicated by the fact that it catalyzed the efficient synthesis of fl-lactam antibiotics, capsaicin derivatives, and N-fatty-acyl-amino acid/N-fatty-acyl-peptide derivatives.
- リンク情報
- ID情報
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- DOI : 10.1271/bbb.70052
- ISSN : 0916-8451
- eISSN : 1347-6947
- Web of Science ID : WOS:000247793300029