We recently reported that helical poly-1 induced by an optically active amidine ((R,R)-2) showed helix-helix transition in response to temperature, and the diastereomeric right- and left-handed helices of poly-1 induced by (R,R)-2 could be separately memorized by the replacement of (R,R)-2 with achiral amines. In this study, we have found that the helix-sense of poly-1 induced by (R,R)-2 underwent a transition from one helix to another in response to the change of solvent composition. Furthermore, the right- and left-handed helices of poly-1 induced by (R,R)-2 in DMSO/pyridine (7/3) and DMSO/acetonitrile (7/3), respectively, could be memorized when (R,R)-2 was replaced by achiral amines.