Ken J ISHII

Profile Information

Affiliation: Professor, The Institute of Medical Science, The University of Tokyo
: (Concurrent)Director, International Vaccine Design Center

Degree: M.D., Ph.D.

Other name(s) (e.g. nickname): Ken J. Ishii
J-GLOBAL ID: 200901057602136302
researchmap Member ID: 5000077362

External link: http://www.vaccine-science.ims.u-tokyo.ac.jp/

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Vice Director, UTOPIA Center, The University of Tokyo
Apr, 2022 - Present

Director, International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo
Jan, 2019 - Present

Professor, Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
Apr, 2010 - Present

Visiting Professor, Lab. Vaccine Science, WPI Immunology Frontier Research Center (iFREC), Osaka University
Apr, 2019 - Mar, 2022

Director, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo
Apr, 2017 - Dec, 2018

Director, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition
Oct, 2015 - Mar, 2017

Managing Director, Department of Research Promotion, Japan Agency for Medical Research and Development
Apr, 2015 - Sep, 2015

Director, Center for Drug Design Research, Natioanl Institutes of Biomedical Innvation, Health and Nutrition
Apr, 2010 - Mar, 2015

Project Leader, Lab. Adjuvant Innovation,, National institute of Biomedical innovation (NIBIO)
Oct, 2007 - Mar, 2010

Associate Professor, WPI immunology Frontier Rsearch Center (iFREC), Osaka University
Dec, 2006 - Mar, 2010

Associate Professor, Research Institute for Microbial Diseases, Osaka University
Sep, 2003 - Oct, 2007

Group Leader, JST ERATO AKIRA innate immunity project
Mar, 2000 - Aug, 2003

IND reviewer, Division of Viral Products, CBER, OVRR, FDA
Sep, 1996 - Feb, 2000

Visiting Scientist, CBER, OVRR, FDA,, US. Gov
Apr, 1995 - Aug, 1996

Dep. of Anesthesiology
Apr, 1995 - Mar, 1996

Anesthesiologist, Yokoyama City municipal hospital
Apr, 1993 - Mar, 1995

Resident, Yokohama City University Hospital

Committee Memberships

2009 - 2019

生物審査第２部専門委員, （独）医薬品医療機器総合機構（ＰＭＤＡ）
2015 - 2017

戦略推進部長, 日本医療研究開発機構（AMED)
2008 - 2010

学術調査官, 文部科学省・研究振興局・

Awards

Dec, 2019

JSI award, Japanese Society of Immunology
Oct, 2014

Osaka Science Prize

ISHII Ken
2011

第35回多ヶ谷勇記念ワクチン研究奨励賞

石井健
2008

大阪大学研究教育功労賞
2008

日本免疫学会研究奨励賞
2003

Individual award for special acomplishment, DHHS, US government
2002

Individual award for special acomplishment, DHHS, US government
2001

Individual award for special acomplishment, DHHS, US government
2000

Individual award for contribution to public health mission, DHHS, US government

Papers

202

Immune tolerance caused by repeated P. falciparum infection against SE36 malaria vaccine candidate antigen and the resulting limited polymorphism.

Nirianne Marie Q Palacpac, Ken J Ishii, Nobuko Arisue, Takahiro Tougan, Toshihiro Horii

Parasitology international, 99 102845-102845, Apr, 2024
Acute malaria suppresses the B lymphocytic niche in the bone marrow through the alteration of CXCL12-abundant reticular cells

Michelle Sue Jann Lee, Julia Matsuo-Dapaah, Camila Del Rosario Zorrilla, Yoshiki Omatsu, Takashi Nagasawa, Shun Uemura, Atsushi Iwama, Ken J Ishii, Cevayir Coban

International Immunology, Mar 2, 2024
Challenges in developing personalized neoantigen cancer vaccines.

Peter D Katsikis, Ken J Ishii, Christopher Schliehe

Nature reviews. Immunology, 24(3) 213-227, Mar, 2024
Integrin α5 regulates motility of human monocyte-derived Langerhans cells during immune response.

Zhihan Guo, Masato Murakami, Kaori Saito, Hiroko Kato, Manami Toriyama, Makoto Tominaga, Ken J Ishii, Fumitaka Fujita

Experimental dermatology, 33(3) e15021, Mar, 2024
Virological characteristics of the SARS-CoV-2 JN.1 variant.

Yu Kaku, Kaho Okumura, Miguel Padilla-Blanco, Yusuke Kosugi, Keiya Uriu, Alfredo A Hinay Jr, Luo Chen, Arnon Plianchaisuk, Kouji Kobiyama, Ken J Ishii …

The Lancet. Infectious diseases, Jan 3, 2024
5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation.

Burcu Temizoz, Takayuki Shibahara, Kou Hioki, Tomoya Hayashi, Kouji Kobiyama, Michelle Sue Jann Lee, Naz Surucu, Erdal Sag, Atsushi Kumanogoh, Masahiro Yamamoto …

Frontiers in immunology, 15 1353336-1353336, 2024
Antibody Response Following the Intranasal Administration of SARS-CoV-2 Spike Protein-CpG Oligonucleotide Vaccine

Kentaro Muranishi, Mao Kinoshita, Keita Inoue, Junya Ohara, Toshihito Mihara, Kazuki Sudo, Ken J. Ishii, Teiji Sawa, Hiroyasu Ishikura

Vaccines, Dec 20, 2023
Antibody Response Following the Intranasal Administration of SARS-CoV-2 Spike Protein-CpG Oligonucleotide Vaccine

Kentaro Muranishi, Mao Kinoshita, Keita Inoue, Junya Ohara, Toshihito Mihara, Kazuki Sudo, Ken J Ishii, Teiji Sawa, Hiroyasu Ishikura

Vaccines, Dec, 2023
Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci.

Chieko Yokota, Kosuke Fujimoto, Natsuko Yamakawa, Masamitsu Kono, Daichi Miyaoka, Masaki Shimohigoshi, Miho Uematsu, Miki Watanabe, Yukari Kamei, Akira Sugimoto …

Inflammation and regeneration, 43(1) 55-55, Nov 15, 2023
The 100 Days Mission: how a new medical-countermeasures network can deliver equity and innovation.

Victor Dzau, Soumya Swaminathan, Charlotte Baker, Rick A Bright, Jose Castillo, Tan Chorh Chuan, Ruxandra Draghia-Akli, Ranna Eardley-Patel, George F Gao, Ken Ishii …

Lancet (London, England), 402(10412) 1507-1510, Oct 28, 2023
Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals.

Yuxin Wang, Tatsuya Morishima, Maiko Sezaki, Ryo Sato, Gaku Nakato, Shinji Fukuda, Kouji Kobiyama, Ken J Ishii, Yuhua Li, Hitoshi Takizawa

EMBO reports, e57485, Oct 23, 2023
Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile.

Shao-Hua Zhuo, Naotaka Noda, Kou Hioki, Shuyu Jin, Tomoya Hayashi, Kou Hiraga, Haruka Momose, Wen-Hao Li, Lang Zhao, Takuo Mizukami …

Journal of medicinal chemistry, 66(18) 13266-13279, Sep 28, 2023
Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome.

Hachiro Konaka, Yasuhiro Kato, Toru Hirano, Kohei Tsujimoto, JeongHoon Park, Taro Koba, Wataru Aoki, Yusei Matsuzaki, Masayasu Taki, Shohei Koyama …

The EMBO journal, 42(20) e112573, Sep 4, 2023
Intratumoural Delivery of mRNA Loaded on a Cationic Hyper-Branched Cyclodextrin-Based Polymer Induced an Anti-Tumour Immunological Response in Melanoma.

Yousef Khazaei Monfared, Mohammad Mahmoudian, Parvin Zakeri-Milani, Claudio Cecone, Tomoya Hayashi, Ken J Ishii, João Conde, Adrián Matencio, Francesco Trotta

Cancers, 15(14), Jul 24, 2023
A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages

Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Takashi Orimo, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta …

bioRxiv, Jul 7, 2023
Spermidine enhances the efficacy of adjuvant in HBV vaccination in mice

Daisuke Ito, Hiroyasu Ito, Tatsuya Ando, Yasuhiro Sakai, Takayasu Ideta, Ken J. Ishii, Tetsuya Ishikawa, Masahito Shimizu

Hepatology Communications, Apr, 2023
TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells

Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Huangwenxian Lan, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Ken J. Ishii, Shizuo Akira …

International Immunopharmacology, 117 109852-109852, Apr, 2023
Roles of TRPM4 in immune responses in keratinocytes and identification of a novel TRPM4-activating agent

Kaori (Otsuka) Saito, Fumitaka Fujita, Manami Toriyama, Ratna Annisa Utami, Zhihan Guo, Masato Murakami, Hiroko Kato, Yoshiro Suzuki, Fumihiro Okada, Makoto Tominaga …

Biochemical and Biophysical Research Communications, Feb, 2023
A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via α-tocopherol component.

Yuya Yoshioka, Kouji Kobiyama, Tomoya Hayashi, Motoyasu Onishi, Yosuke Yanagida, Takayuki Nakagawa, Masayuki Hashimoto, Anri Nishinaka, Jun Hirose, Yoshiji Asaoka …

Frontiers in immunology, 14 1116238-1116238, 2023
Dendritic cell proliferation by primary cilium in atopic dermatitis.

Manami Toriyama, Defri Rizaldy, Motoki Nakamura, Yukiko Atsumi, Michinori Toriyama, Fumitaka Fujita, Fumihiro Okada, Akimichi Morita, Hiroshi Itoh, Ken J Ishii

Frontiers in molecular biosciences, 10 1149828-1149828, 2023