TAKAHASHI Toshio

J-GLOBAL         Last updated: Dec 2, 2019 at 16:15
 
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Name
TAKAHASHI Toshio
E-mail
takahashisunbor.or.jp
Affiliation
SUNTORY FOUNDATION FOR LIFE SCIENCES
Job title
Researcher
Degree
Doctor(Dissertation)(Hiroshima University)
Research funding number
20390792

Research Areas

 
 

Academic & Professional Experience

 
1997
 - 
2000
Japan Society for the Promotion of Science
 
2004
   
 
- Suntory Institute for Bioorganic Research
 

Education

 
 
 - 
1992
Zoological Institute・Biological Science, Faculty of Science, Hiroshima University
 
 
 - 
1997
Biology, Graduate School, Division of Biophere Sciences, Hiroshima University
 

Awards & Honors

 
Jul 2014
Best Short Oral Presentation Award, 4th International Symposium on Non-neuronal Acetylcholine
 

Published Papers

 
Organoids for Drug Discovery and Personalized Medicine
59 447-462   2019   [Refereed][Invited]
Visualization of acetylcholine distribution in intestinal tissue sections by tandem imaging mass spectrometry and its function in mice
142 203-204   2017   [Refereed]
High-resolution mass spectrometry for detecting Acetylcholine in Arabidopsis
10 e1074367   2015   [Refereed]
Insight into the molecular and functional diversity of cnidarian neuropeptides
16 2610-2625   2015   [Refereed]
Non-neuronal acetylcholine as an endogenous regulator of proliferation and differentiation of Lgr5-positive stem cells in mice
281 4672-4690   2014   [Refereed]
Neuropeptides and epitheliopeptides: Structure and functional diversity in an ancestral metazoan Hydra
20 671-680   2013   [Refereed]
Subcellular localization of the epitheliopeptode, Hym-301 in hydra
351 419-424   2013   [Refereed]
Neuropeptides trigger oocyte maturation and subsequent spawning in the hydrozoan jellyfish Cytaeis uchidae
80 223-232   2013   [Refereed]
Identification and developmental expression of leucine-rich repeat-containing G protein-coupled receptor 6 (lgr6) in the medaka fish, Oryzias Latipes
222 217-227   2012   [Refereed]
Morphological and moleculer analysis of the Nematostella vectensis cnidom
6 e22725   2011   [Refereed]
Molecular characterization of Hydra acetylcholinesterase and its catalytic activity
584 511-516   2010   [Refereed]
The dynamic genome of Hydra
464 592-596   2010   [Refereed]
Peptidomic approaches to the identification and characterization of functional peptides in Hydra
615 275-292   2010   [Refereed]
Important roles for epithelial cell peptides in hydra development
31 610-619   2009   [Refereed]
Further characterization of the PW peptide family that inhibits neuron differentiation in Hydra
Dev. Genes Evol.   219 119-129   2009   [Refereed]
Neuropeptides and their functions in Hydra
Acta Biol. Hung.   59 227-235   2008   [Refereed]
A novel neuropeptide (FRamide) family identified by a peptidomic approach in Hydra magnipapillata
FEBS J.   274 5438-5448   2007   [Refereed]
Identification of a new member of the GLWamide peptide family: physiological activity and cellular localization in cnidarian polyps
135 309-324   2003   [Refereed]
2003 Jun.
Identification of a vasopressin-like immunoreactive substance in hydra
Peptides   24 17-26   2003   [Refereed]
2003 Jan.
Enhancement of foot formation in Hydra by a novel epitheliopeptide, Hym-323
Development   128 437-446   2001   [Refereed]
Comparative aspects of invertebrate neuropeptides
Acta Biologica Hungarica   51 111-132   2000   [Refereed]
A novel neuropeptide, Hym-355, positively regulates neuron differentiation in Hydra
Development   127 997-1005   2000   [Refereed]
Identification of an astacin matrix metalloprotease as target gene for Hydra foot activator peptides
Dev. Genes Evol.   209 601-607   1999   [Refereed]
Biochem. Biophys. Res. Comm.   248 584-590   1998   [Refereed]
Structure-activity relation of LWamide peptides synthesized with a multipeptide synthesizer
Peptide Chemistry 1996: C. Kitada(Ed.) Protein Research Foundation, Osaka   193-196   1997   [Refereed]
Systematic isolation of peptide signal molecules regulating development in hydra: LWamide and PW families
Proc. Natl. Acad. Sci. USA   94 1241-1246   1997   [Refereed]
T. Takahashi, Y. Muneoka, J. Lohman, M. S. L. DeHaro, G. Solleder, T. C. G. Bosch, C. N. David, H. R. Bode, O. Koizumi, H. Shimizu, M. Hatta, T. Fujisawa and T. Sugiyama. Systematic isolation of peptide signal molecules regulating development In h...
Comparison of accumulative inactivation between the Aplysia K+ channel (Akv1.1a) and its amino-terminal deletion mutant
Zool. Sci.   14 397-408   1997   [Refereed]
Inhibitory pentapeptides isolated from the gut of the earthworm, Eisenia foetida
Comp. Biochem. Physiol.   114 245-249   1996   [Refereed]
Bioactive peptides isolated from an african ancient-type fish, Polypterus senegalus
Peptide Chemistry 1995: N. Nishi(Ed.) Protein Research Foundation, Osaka   189-192   1996   [Refereed]
Structure and action of bioactive peptides isolated from the newt, Cynops pyrrhogaster - II. Four VIP-related peptides and two neurotensin-related peptides
Peptide Chemistry 1995: N. Nishi(Ed.) Protein Research Foundation, Osaka   177-180   1996   [Refereed]
H. Teranishi, T. Takahashi, M. Ohtani, M. Ando, Y. Muneoka, C. Chiba, T. Saito, T. Takao and Y. Shimonishi. Structure and action of bioactive peptides isolated from the newt, Cynops pyrrhogaster-II. Four VIP-related peptides and two neurote...
Bioactive peptides isolated from the clam Meretrix lusoria
Acta Biologica Hungarica   46 453-456   1995   [Refereed]
Bioactive peptides of annelids are closely related to those of molluscs
Acta Biologica Hungarica   46 453-456   1995   [Refereed]
Effects of myomodulin-CARP Family peptides and analogues on the anterior byssus retractor muscle of Mytilus edulis
Peptide Chemistry 1994: M. Ohno(Ed.) Protein Research Foundation, Osaka   289-292   1995   [Refereed]
Comparative aspects of structure and action of bioactive peptides isolated from the seacucumber Stichopus japonicus
Peptide Chemistry 1994: M. Ohno (Ed.) Protein Research Foundation, Osaka   261-264   1995   [Refereed]
Isolation and characterization of four novel bioactive peptides from a polychaete annelid, Perinereis vancaurica
Comp. Biochem. Physiol.   110C 297-304   1995   [Refereed]
Myotropic actions of apisin, a novel peptide isolated from the honey bee Apis Mellifera
Peptide Chemistry 1994: M. Ohno(Ed.) Protein Research Foundation, Osaka   257-260   1995   [Refereed]
Isolation and characterization of opioid peptides in the avian brain
J. Exp. Zool.   273 87-95   1995   [Refereed]
Bioactive peptides isolated from an annelid, Perinereis vancaurica
Peptide Chemistry 1993: Y. Okada(Ed.) Protein Research Foundation, Osaka   169-172   1994   [Refereed]
An invertebrate-type tachykinin isolated from the freshwater bivalve mollusc, Anodonta cygnes
Peptide Chemistry 1993:Y. Okada(Ed.) Protein Research Foundation, Osaka   161-164   1994   [Refereed]
Phylogenetic aspects of structure and action of molluscan neuropeptides
Perspectives in Comparative Endocrinology, National Research Council of Canada   109-118   1994   [Refereed]
A myomodulin-CARP-related peptide isolated from a polychaete annelid, Perinereia vancaurica
Zool. Sci.   11 33-38   1994   [Refereed]
Effects of several peptides with Pro-Arg-Leu-NH2 C-terminal sequence on invertebrate muscles
Comp. Biochem. Physiol.   105C 471-477   1993   [Refereed]
Further identification of bioactive peptides in the anterior byssus retractor muscle of Mytilus: Two contractile and three inhibitory peptides
Comp. Biochem. Physiol.   106C 261-267   1993   [Refereed]
Two S-Iamide peptides, AKSGFVRIamide and VSSFVRIamide, isolated from an annelid, Perinereis vancaurica
Biol. Bull.   184 216-222   1993   [Refereed]
April, 1993

Books etc

 
Cnidarian peptide signaling molecules
2019   
Hym-301
2015   
Hym-176
2015   
GLWamide
2015   
Hym-323
2015   
Head Activator
2015   
LF Peptides
2015   
生理活性ペプチドを“見つける”技
2015   
Evolutionary aspects of molecular forms and biological functions of acetylcholinesterase
2012   

Conference Activities & Talks

 
The α2β4 nicotinic acetylcholine receptor controls intestinal stem cell proliferation and differentiation in mice
Takahashi T
5th International Symposium on Non-neuronal Acetylcholine: from bench to bedside   27 Sep 2019   
Intestinal stem cell homeostasis via muscarinic acetylcholine receptors
23 Nov 2018   
Non-neuronal functions of acetylcholine via muscarinic receptor subtypes: Intestinal stem cell proliferation and differentiation
14 Nov 2016   
Visualization of acetylcholine distribution in intestinal tissue sections by tandem imaging mass spectrometry and its function in mice
16 Oct 2016   
Non-neuronal acetylcholine is an endogenous regulator of proliferation and differentiation of Lgr5-positive stem cells in mouse gut
28 Aug 2014   
Non-neuronal acetylcholine as an endogenous regulator of proliferation and differentiation of Lgr5-positive stem cells in mice
28 Jul 2014   
Identification and developmental expression of leucine-rich repeat-containing G protein-coupled receptor (lgr6) in the medaka fish, Oryzias latipes
28 May 2012   
Important roles for GLWamide family in cnidarian development and physiology [Invited]
8 Jul 2009   
Evolutionary implication of cholinergic system in Hydra
28 May 2009   
Important roles for epithelial cell molecules in hydra development [Invited]
19 May 2009   
Non-neuronal cholinergic system involved in regulation of the developmental processes in Hydra
28 May 2008   
Cholinergic system in hydra and its evolutionary implication
31 Aug 2006   

Research Grants & Projects

 
Search for new ligands of orphan G-protein coupled receptors in hydra.
Project Year: 2004 - 2007
Functional analyses of bioactive peptides isolated from Octopus
Project Year: 2004 - 2007
Search for new ligand of orphan G-protein coupled receptors in mammal.
Project Year: 2001 - 2007