論文

査読有り
2018年4月4日

Formation Process of Hydroxyapatite Granules in Agarose Hydrogel by Electrophoresis

Crystal Growth and Design
  • Kenshiro Kimura
  • ,
  • Masanobu Kamitakahara
  • ,
  • Taishi Yokoi
  • ,
  • Koji Ioku

18
4
開始ページ
1961
終了ページ
1966
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/acs.cgd.7b01154
出版者・発行元
American Chemical Society

Biomimetic mineralization is useful in obtaining organic-inorganic composite and inorganic materials with controlled sizes and morphologies. The formation of hydroxyapatite (HA) granules with porous structures can be achieved by using electrophoresis processes inside an agarose gel in which the compulsory migration of calcium and phosphate ions are driven by an electric field, causing precipitation of the granules. In the present study, we examined the formation process of HA granules through electrophoresis and the subsequent aging process. Spherical particles of amorphous calcium phosphate (ACP) precipitated, increasing their size with increased running time during electrophoresis
then the ACP granules gradually transformed to the HA granules during the aging process in ultrapure water. When the ACP granules were large, one HA granule was formed from one ACP granule. One HA granule was formed from multiple ACP granules for small-sized ACP granules. The size of ACP granules depends on the gel concentration and pH in the electrophoresis. The dominant transformation process from ACP to HA was the dissolution-precipitation process.

リンク情報
DOI
https://doi.org/10.1021/acs.cgd.7b01154
ID情報
  • DOI : 10.1021/acs.cgd.7b01154
  • ISSN : 1528-7505
  • ISSN : 1528-7483
  • SCOPUS ID : 85044941582

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