In this study, we evaluated cellular radiosensitivity and radiosensitizing properties to hypoxic cells in the combination of immune cells and radiosensitizers, and created clinically applicable immunoradiosensitizers based on temporal radiation biology models Dose evaluation and treatment plan optimization were constructed. First, we examined the co-culture conditions in case of adding immune cells to tumor cells and the tumoricidal effect of ultraviolet light on the sensitizer (titanium oxide particles). On the basis of those results, it was useful in performing calculation simulation with chronoradiobiology model, examining clinical treatment plan combined with detailed influence factor of biological parameter, and predicting and evaluating treatment effect.