Sasaki Takeshi

Profile Information

Affiliation: Hamamatsu University School of Medicine
: (Concurrent)Faculty of Medicine
: School of Medicine, Nagoya University

Degree: 農学博士(名古屋大学)

J-GLOBAL ID: 200901097957904310
researchmap Member ID: 5000080806

External link: http://kaken.nii.ac.jp/ja/r/20397433

Research Interests

Research Areas

Research History

Apr, 2022 - Present

Hamamatsu University School of Medicine
Apr, 2019 - Present

Hamamatsu University School of Medicine
2016 - Present

Faculty of Medicine, Hamamatsu University School of Medicine
2009 - 2016

Faculty of Medicine, Hamamatsu University School of Medicine
2004 - 2009

Faculty of Medicine, Hamamatsu University School of Medicine
2001 - 2004

Graduate School of Medicine, Nagoya University
1999 - 2001

Graduate School of Bioagricultural Sciences, Nagoya University

Education

Awards

2018

優秀研究賞, 第2回中性脂肪学会

佐々木健
2018

優秀研究賞, 第23回浜松医科学シンポジウム

佐々木健
2017

優秀研究賞, 第22回浜松医科学シンポジウム

佐々木健
2015

優秀研究賞, 第15回浜松医科学シンポジウム

佐々木健
2013

ポスター賞, 第18回静岡健康・長寿学術フォーラム

加藤裟智穂, 竹村綾奈, 佐々木健
2010

研究奨励賞, 浜松医科大学

佐々木健
2009

名古屋メタボリックシンドローム研究会研究奨励賞
2007

名古屋メタボリックシンドローム研究会研究奨励賞

Papers

100

Young bone marrow transplantation prevents aging‐related muscle atrophy in a senescence‐accelerated mouse prone 10 model

Aiko Inoue, Limei Piao, Xueling Yue, Zhe Huang, Lina Hu, Hongxian Wu, Xiangkun Meng, Wenhu Xu, Chenglin Yu, Takeshi Sasaki …

Journal of Cachexia, Sarcopenia and Muscle, Sep 4, 2022
Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress

Xueling Yue, Limei Piao, Hailong Wang, Zhe Huang, Xiangkun Meng, Takeshi Sasaki, Aiko Inoue, Kae Nakamura, Ying Wan, Shengnan Xu …

Hypertension, 79(8) 1713-1723, Aug, 2022
Role of Subcutaneous Adipose Tissues in the Pathophysiology of Secondary Lymphedema.

Masaki Sano, Satoshi Hirakawa, Takeshi Sasaki, Kazunori Inuzuka, Kazuto Katahashi, Takafumi Kayama, Yuta Yamanaka, Hajime Tsuyuki, Yusuke Endo, Ena Naruse …

Lymphatic research and biology, 20(6) 593-599, Apr 7, 2022
Differences in Vasa Vasorum Distribution in Human Aortic Aneurysms and Atheromas.

Masaki Sano, Takeshi Sasaki, Satoshi Baba, Kazunori Inuzuka, Kazuto Katahashi, Takafumi Kayama, Yuta Yamanaka, Hajime Tsuyuki, Yusuke Endo, Kohji Sato …

Angiology, 73(6) 33197211063655-33197211063655, Jan 23, 2022
講義実習棟改修時に大量に見つかった骨学実習用標本について.

佐々木健, 相羽民人, 間賀田泰寛, 佐藤康二

静岡大学技術報告, 27 39-42, 2022
Online Anatomy at Hamamatsu University School of Medicine in 2020.

Sasaki T, Sato K

Proceeding of the Annual Meeting on Technologies in Biological Research, 32 78-79, 2021
Online lecture delivery by Technical Department of Hamamatsu University School of Medicine.

Sasaki T, Magata Y, Sato K

Proceeding of the Annual Meeting on Technologies in Biological Research, 32 22-23, 2021
Potential role of transforming growth factor-beta 1/Smad signaling in secondary lymphedema after cancer surgery.

Masaki Sano, Satoshi Hirakawa, Minoru Suzuki, Jun-Ichi Sakabe, Mikako Ogawa, Seiji Yamamoto, Takanori Hiraide, Takeshi Sasaki, Naoto Yamamoto, Kazunori Inuzuka …

Cancer science, 111(7) 2620-2634, May 15, 2020 Peer-reviewed
Deficiency of cysteinyl cathepsin K suppresses the development of experimental intimal hyperplasia in response to chronic stress.

Xiangkun Meng, Limei Piao, Hailong Wang, Aiko Inoue, Zhe Huang, Haiying Jiang, Kae Nakamura, Takeshi Sasaki, Xiang Li, Wenhu Xu …

Journal of hypertension, 38(8) 1514-1524, Mar 19, 2020 Peer-reviewed
The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model.

Hiroki Tanaka, Nobuhiro Zaima, Hirona Kugo, Tatsuro Yata, Yasunori Iida, Keisuke Hashimoto, Chie Miyamoto, Takeshi Sasaki, Hideto Sano, Yuko Suzuki …

Annals of vascular surgery, 63 382-390, Feb, 2020 Peer-reviewed
The risks and preventive measures of infection in embalming treatments of body donation, and one false positive case of HBV infection.

Sasaki T, Aiba T, Minoshima S, Sato K

Proceeding of the Annual Meeting on Technologies in Biological Research, 31 26-29, 2020
Video Recording of Research Technologies for Efficient Research Supports and Technology Succession.

Sasaki T, Doshita C, Oyama K, Yamaguchi M, Nagaya M, Teratani C, Hirata S, Sato K

Proceeding of the Annual Meeting on Technologies in Biological Research, 31 136-137, 2020
同じ宿主動物由来の一次抗体を用いた多重免疫染色とその条件検討

佐々木健, 宮田学, 高林秀次, 蓑島伸生, 佐藤康二

静岡大学技術報告, 2020
Cathepsin S Deficiency Mitigated Chronic Stress-Related Neointimal Hyperplasia in Mice.

Hailong Wang, Xiangkun Meng, Limei Piao, Aiko Inoue, Wenhu Xu, Chenglin Yu, Kae Nakamura, Lina Hu, Takeshi Sasaki, Hongxian Wu …

Journal of the American Heart Association, 8(14) e011994, Jul 16, 2019 Peer-reviewed
Immune Disorder in Atherosclerotic Cardiovascular Disease - Clinical Implications of Using Circulating T-Cell Subsets as Biomarkers.

Neupane R, Jin X, Sasaki T, Li X, Murohara T, Cheng XW

Circ J, 83 1431-1438, 2019
Know-how of holding seminars in the university by the technical department and staff.

Sasaki T, Miyata M, Minoshima S, Sato K

Proceeding of the Annual Meeting on Technologies in Biological Research, 30 80-83, 2019
Proliferation of Large Amounts of Molds in Cadaver Dissection Room of Hamamatsu University School of Medicine and its Countermeasures.

Sasaki T, Hirata S, Yamamoto M, Oyama K, Nakamura M, Sato K

Proceeding of the Annual Meeting on Technologies in Biological Research, 30 186-187, 2019
Elevated Plasma Levels of LDL Cholesterol Promote Dissecting Thoracic Aortic Aneurysms in Angiotensin II-Induced Mice.

Hiroki Tanaka, Yasunori Iida, Takayuki Iwaki, Yuko Suzuki, Hideto Sano, Chiharu Miyajima, Nobuhiro Zaima, Takeshi Sasaki, Ayato Sumioka, Shogo Hakamata …

Annals of vascular surgery, 48 204-213, Apr, 2018 Peer-reviewed
Inflammatory Cells and Proteases in Abdominal Aortic Aneurysm and its Complications.

Haiying Jiang, Takeshi Sasaki, Enze Jin, Masafumi Kuzuya, Xian Wu Cheng

Current drug targets, 19(11) 1289-1296, 2018 Peer-reviewedInvited
Contribution to Society through Anatomical Education at Hamamatsu University School of Medicine.

Sasaki T, Sato K

Proceeding of the Annual Meeting on Technologies in Biological Research, 29 162-163, 2018

Misc.

血管壁に異常出現する脂肪細胞が腹部大動脈瘤破裂に及ぼす影響の評価

財満信宏, 久後裕菜, 田中宏樹, 佐々木健, 浦野哲盟, 海野直樹, 森山達哉

脈管学, 58(Suppl.) S255-S255, Sep, 2018
EPA高含有魚油投与が腹部大動脈瘤の進展と破裂に及ぼす影響の評価

久後裕菜, 財満信宏, 田中宏樹, 柳本賢一, 佐々木健, 浦野哲盟, 海野直樹, 森山達哉

脈管学, 58(Suppl.) S255-S255, Sep, 2018
腹部大動脈瘤の破裂機構の解明と破裂予防法の検討

財満信宏, 久後裕菜, 田中宏樹, 柳本賢一, 佐々木健, 浦野哲盟, 海野直樹, 森山達哉

脂質生化学研究, 59 43-43, Jun, 2017
腹部大動脈瘤の破裂機構の解明と破裂予防法の検討

財満信宏, 久後裕菜, 田中宏樹, 柳本賢一, 佐々木健, 浦野哲盟, 海野直樹, 森山達哉

脂質生化学研究, 59 43-43, Jun, 2017
血管壁に異常出現した脂肪細胞が腹部大動脈瘤破裂を誘導する

久後裕菜, 財満信宏, 田中宏樹, 毛利陽平, 柳本賢一, 佐々木健, 浦野哲盟, 海野直樹, 森山達哉

日本栄養・食糧学会大会講演要旨集, 71回 340-340, Apr, 2017
非動脈硬化性内臓動脈瘤にみられる特徴的な脂質分子の局在質量顕微鏡法による組織解析

田中宏樹, 山本尚人, 犬塚和徳, 浦野哲盟, 佐々木健, 瀬藤光利, 海野直樹, 今野弘之

日本外科学会定期学術集会抄録集, 116回 PS-8, Apr, 2016
新しい腹部大動脈瘤動物モデルの開発大動脈壁の虚血が瘤化を惹起する

田中宏樹, 財満信宏, 佐々木健, 山本尚人, 犬塚和徳, 佐野真規, 斎藤貴明, 杉澤良太, 片橋一人, 矢田達朗 …

脈管学, 55(Suppl.) S122-S122, Oct, 2015
リンパ還流不全による静脈壁ならびに静脈周囲組織変性についての実験的検討

田中宏樹, 財満信宏, 佐々木健, 今野弘之, 瀬藤光利, 海野直樹

静脈学, 26(3) 227-235, Aug, 2015
HMG-CoA Reductase Inhibition Enhances Renoprotective Effects of Angiotensin Receptor1 Antagonism in Salt -Sensitive Hypertensive Rats

Lina Hu, Xian Wu Cheng, Zhe Huang, Takeshi Sasaki, Aiko Inoue, Hongxian Wu, Enbo Zhu, Masafumi Kuzuya, Toyoaki Murohara, Kenji Okumura

CIRCULATION, 130, Nov, 2014
HMG-CoA Reductase Inhibitor Pitavastatin Enhances Renoprotective Effects of Angiotensin Receptor1 Blocker Olmesartan In Salt-Sensitive Hypertensive Rats

Aiko Inoue, Xian Wu Cheng, Takeshi Sasaki, Lina Hu, Haiying Jang, Li Xiang, Masafumi Kuzuya, Toyoaki Murohara, Kenji Okumura

CIRCULATION, 128(22), Nov, 2013
動脈硬化の臨床と病理腹部大動脈瘤壁外膜vaso vasorumの動脈硬化と瘤壁組織の低酸素についての病理学的研究

海野直樹, 田中宏樹, 財満信宏, 佐々木健, 山本尚人, 鈴木実, 眞野勇記, 佐野真規, 斉藤貴明, 杉澤良太 …

脈管学, 52(Suppl.) S78-S79, Sep, 2012
腹部大動脈瘤壁外膜vaso vasorumの動脈硬化と瘤壁組織の低酸素についての病理学的研究

海野直樹, 田中宏樹, 田中宏樹, 財満信宏, 財満信宏, 佐々木健, 山本尚人, 鈴木実, 眞野勇記, 佐野真規 …

脈管学(Web), 52(supplement), 2012
Statins Enhance the Beneficial Effects of Olmesartan on Renal Injury in Salt-Sensitive Hypertensive Rats via the Reduction of an Angiotensin-Mineralocorticoid Receptor Signaling Interaction

Xian Wu Cheng, Aiko Inoue, Lina Hu, Haizhen Song, Takeshi Sasaki, Masafumi Kuzuya, Kenji Okumura, Toyoaki Murohara

CIRCULATION, 124(21), Nov, 2011
リンパ還流不全による静脈壁並びに静脈周囲組織変性についての実験的検討

田中宏樹, 海野直樹, 山本尚人, 鈴木実, 眞野勇記, 佐野真規, 斉藤貴明, 財満信宏, 佐々木健, 今野弘之 …

脈管学, 51(Suppl.) S100-S100, Sep, 2011
Superoxide-Dependent Cathepsin Activation is Associated with Hypertensive Renal Remodeling and Dysfunction and Represents a Target for Angiotensin Type 1 Receptor Blocker

Xian Wu Cheng, Takeshi Sasaki, Haizhen Song, Aiko Inoue, Janglin Fan, Akihiro Hirashiki, Guo-Ping Shi, Kenji Okumura, Masafumi Kuzuya, Toyoaki Murohara

CIRCULATION, 122(21), Nov, 2010
Statin-Induced Prevention of Hypertensive Renal Insufficiency Through Reduction of Local Angiotensin Synthesis and NADPH Oxidase-Dependent Activation of the Mineralocorticoid Receptor

Xian Wu Cheng, Kenji Okumura, Aiko Inoue, Lina Hu, Haizhen Song, Takeshi Sasaki, Masafumi Kuzuya, Toyoaki Murohara

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(11) E232-E232, Nov, 2010
一次性下肢静脈瘤の弁不全機序に関与する脂質分子の同定

田中宏樹, 海野直樹, 山本尚人, 相良大輔, 鈴木実, 西山元啓, 眞野勇記, 佐野真規, 財満信宏, 佐々木健 …

日本外科学会雑誌, 111(臨増2) 247-247, Mar, 2010
Superoxide-Dependent Cathepsin Activation System is Associated with Hypertensive Renal Remodeling and Represents a Target for Statin

Xian Wu Cheng, Kenji Okumura, Takeshi Sasaki, Kazumasa Unno, Hideo Izawa, Akihiro Hirashiki, Kohzo Nagata, Masafumi Kuzuya, Mitsuhiro Yokota, Toyoaki Murohara

CIRCULATION, 120(18) S1062-S1063, Nov, 2009
SUPEROXIDE-DEPENDENT CATHEPSIN ACTIVATION SYSTEM IS ASSOCIATED WITH HYPERTENSIVE RENAL REMODELING AND REPRESENTS A TARGET FOR STATIN TREATMENT

X. W. Cheng, K. Okumura, T. Sasaki, M. Kuzuya, T. Murohara

ATHEROSCLEROSIS SUPPLEMENTS, 10(2), Jun, 2009
TREATMENT OF APO E-DEFICIENT MICE WITH STATIN INHIBITS THE OXIDATIVE STRESS-DEPENDENT LYSOSMAL PROTEASE CATHEPSIN ACTIVATION SYSTEM: IMPLICATION FOR PLAQUE STABILITY

X. W. Cheng, M. Kuuzya, T. Sasaki, K. Nakamura, H. Song, L. Hu, A. Inoue, G-P Shi, T. Murohara, K. Okumura

ATHEROSCLEROSIS SUPPLEMENTS, 10(2), Jun, 2009

Books and Other Publications

小動物の血栓症・動脈硬化モデル作成法 (プラーク破綻モデル,115-123)

金芳堂, 2007
'Effects of opioid peptides on neurohypophysial hormone release in chicks' in "Recent Progress in Molecular Comparative Endocrinology" (Edited by H. B. Kwon, J. M. P. Joss and S. Ishii)

Hormone Research Center, 1999

Professional Memberships

Research Projects

エイコサペンタエン酸のTGF-β1抑制作用に着目したリンパ浮腫薬物療法の開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

佐野真規, 佐々木健
Development of effective method for preventing abdominal aortic aneurysm

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025
血管周囲脂肪細胞による血管壁炎症に着目した腹部大動脈瘤形成の機序解明と治療戦略

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

佐々木健, 財満信宏, 佐野真規
腹部大動脈瘤の進展・破裂予防法の確立

科学研究費補助金基盤B, 文部科学省科研費, Apr, 2017 - Mar, 2021

財満信宏
腹部大動脈瘤における血管周囲脂肪組織の関与とその治療を見据えた基盤構築

科学研究費補助金基盤C, 文部科学省科研費, Apr, 2017 - Mar, 2020

佐々木健
ストレス性血管病におけるGLP1/DDP4の新しい作用メカニズム解明と治療応用

科学研究費補助金基盤B, 文部科学省科研費, Apr, 2015 - Mar, 2018

成憲武
腹部大動脈瘤の形成・進展におけるＢ細胞の関与とその治療に向けた基盤構築

科学研究費補助金基盤C, 文部科学省科研費, Apr, 2014 - Mar, 2018

佐々木健
腹部大動脈瘤の進展メカニズムの解明とその治療戦略の基礎構築

科学研究費補助金基盤C, 文部科学省科研費, Apr, 2011 - Mar, 2015

佐々木健
実験動物を用いたアテロームプラーク破綻メカニズムの解明－カテプシンの関与

科学研究費補助金若手B, 文部科学省科研費, Apr, 2009 - Mar, 2011

佐々木健
実験動物を用いたアテロームプラーク破綻メカニズムの解明

科学研究費補助金若手B, 文部科学省科研費, Apr, 2007 - Mar, 2009

佐々木健
The mechanism of atherosclerotic plaque disruption in apoE-deficient mice. The concept of the involvement of inflammation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2007 - 2008

SASAKI Takeshi, KUZUYA Masafumi, CHENG Xian Wu, NAKAMURA Kae, SUZUKI Tohru
実験動物を用いたアテロームプラーク破綻モデルの作成

科学研究費補助金若手B, 文部科学省科研費, Apr, 2005 - Mar, 2007

佐々木健
ApoEノックアウトマウスにおけるプラーク破裂モデルの確立とそのメカニズム解明

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2005 - 2006

佐々木健
動脈硬化巣の石灰化メカニズムに関する研究

補助金, 2006

Industrial Property Rights

大動脈瘤モデル動物

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Research History

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Misc.

Books and Other Publications

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