OKAZAWA Hidehiko

J-GLOBAL         Last updated: Oct 15, 2018 at 13:40
 
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Name
OKAZAWA Hidehiko
Affiliation
University of Fukui
Section
Biomedical Imaging Research Center
Job title
Professor
Degree
M.D., Ph.D.(Kyoto University)

Research Areas

 
 

Academic & Professional Experience

 
1988
 - 
1989
 Kyoto University Hospital, Department of Radiology and Nuclear Medicine, Resident
 
1989
 - 
1992
 Shiga Medical Center, Department of Radiology, Physician
 
1992
 - 
1996
 Kyoto University, Graduate School of Medicine, Graduate School Student
 
1996
   
 
 Department of Nuclear Medicine, Kyoto University Hospital, Clinical staff
 
1996
 - 
1998
 Montreal Neurological Institute, McGill University, Postdoctoral fellow
 

Education

 
 
 - 
1996
内科系, Graduate School, Division of Medicine, Graduate School, Kyoto University
 
 
 - 
1988
School of Medicine, Faculty of Medicine, Kyoto University
 

Committee Memberships

 
1988
   
 
Japan Radiological Society  member
 
2007
   
 
Japanese Society of Nuclear Medicine  councilor
 
1992
   
 
Society of Nuclear Medicine  member
 
1997
   
 
International Society of Cerebral Blood Flow and Metabolism  member
 
1999
   
 
European Association of Nuclear Medicine  member
 

Awards & Honors

 
2011
2011 SNM Annual Meeting Oncology: Clinical Diagnosis, Top 10 Poster Award Finalists: First Place
 
2010
Outstandin JNM Articles for 2009 (Clinical Investigations)
 
2002
The 40th Award of the Japanese Borard of Nuclear Medicine
 

Published Papers

 
Masamichi Ikawa, Hirohiko Kimura, Yuki Kitazaki, Katsuya Sugimoto, Akiko Matsunaga, Kouji Hayashi, Osamu Yamamura, Tetsuya Tsujikawa, Tadanori Hamano, Makoto Yoneda, Hidehiko Okazawa, Yasunari Nakamoto
Journal of the Neurological Sciences   394 58-62   Nov 2018   [Refereed]
© 2018 Elsevier B.V. Purpose: The aim of this study was to evaluate the clinical utility of arterial spin labeling (ASL) magnetic resonance imaging (MRI) for the detection of cerebellar hypoperfusion in patients with spinocerebellar degeneration (...
Rahman MGM, Islam MM, Tsujikawa T, Kiyono Y, Okazawa H
Annals of Nuclear Medicine   32    Oct 2018   [Refereed]
Hidehiko Okazawa, Yoshifumi Higashino, Tetsuya Tsujikawa, Hidetaka Arishima, Tetsuya Mori, Yasushi Kiyono, Hirohiko Kimura, Ken-ichiro Kikuta
European Journal of Radiology   105 102-109   Aug 2018   [Refereed]
Akira Makino, Anna Miyazaki, Ayaka Tomoike, Hiroyuki Kimura, Kenji Arimitsu, Masahiko Hirata, Yoshiro Ohmomo, Ryuichi Nishii, Hidehiko Okazawa, Yasushi Kiyono, Masahiro Ono, Hideo Saji
Bioorganic & Medicinal Chemistry   26(8) 1609-1613   May 2018   [Refereed]
Tetsuya Tsujikawa, Hideaki Tsuyoshi, Masafumi Kanno, Shizuka Yamada, Masato Kobayashi, Norihiko Narita, Hirohiko Kimura, Shigeharu Fujieda, Yoshio Yoshida, Hidehiko Okazawa
Oncotarget   9(29) 20734-20746   Apr 2018   [Refereed]
Yoshitaka Inui, Takashi Ichihara, Masaki Uno, Masanobu Ishiguro, Kengo Ito, Katsuhiko Kato, Hajime Sakuma, Hidehiko Okazawa, Hiroshi Toyama
Annals of Nuclear Medicine   32(5) 311-318   Mar 2018   [Refereed]
Tomoyo Morita, Daisuke N Saito, Midori Ban, Koji Shimada, Yuko Okamoto, Hirotaka Kosaka, Hidehiko Okazawa, Minoru Asada, Eiichi Naito
Cerebral Cortex   28(4) 1532-1548   Feb 2018   [Refereed]
Tetsuya Tsujikawa, Norihiko Narita, Masafumi Kanno, Tetsuji Takabayashi, Shigeharu Fujieda, Hidehiko Okazawa
Annals of Nuclear Medicine   32(4) 239-249   Feb 2018   [Refereed]
Yuko Okamoto, Ryo Kitada, Motohide Miyahara, Takanori Kochiyama, Hiroaki Naruse, Norihiro Sadato, Hidehiko Okazawa, Hirotaka Kosaka
NeuroImage: Clinical   19 384-395   2018   [Refereed]
Tetsuya Tsujikawa, Makoto Yamamoto, Kunihiro Shono, Shizuka Yamada, Hideaki Tsuyoshi, Yasushi Kiyono, Hirohiko Kimura, Hidehiko Okazawa, Yoshio Yoshida
Annals of Nuclear Medicine   31 752-757   Dec 2017   [Refereed]
© 2017, The Japanese Society of Nuclear Medicine. Objective: The aim of this study was to retrospectively evaluate the clinical significance of18F-FDG PET/CT textural features for discriminating uterine sarcoma from leiomyoma. Methods: Fifty-five ...
Tetsuya Tsujikawa, Tasmiah Rahman, Makoto Yamamoto, Shizuka Yamada, Hideaki Tsuyoshi, Yasushi Kiyono, Hirohiko Kimura, Yoshio Yoshida, Hidehiko Okazawa
Annals of Nuclear Medicine   31 678-685   Nov 2017   [Refereed]
© 2017, The Japanese Society of Nuclear Medicine. Objectives: The aims of our study were to find the textural features on18F-FDG PET/CT which reflect the different histological architectures between cervical cancer subtypes and to make a visual as...
Eiichi Naito, Tomoyo Morita, Daisuke N. Saito, Midori Ban, Koji Shimada, Yuko Okamoto, Hirotaka Kosaka, Hidehiko Okazawa, Minoru Asada
Cerebral Cortex   27 5385-5397   Nov 2017   [Refereed]
© The Author 2017. Published by Oxford University Press. Functional lateralization can be an indicator of brain maturation. We have consistently shown that, in the adult brain, proprioceptive processing of muscle spindle afferents generating illus...
Yoshitomo Fukuoka, Akira Nakano, Naoto Tama, Kanae Hasegawa, Hiroyuki Ikeda, Tetsuji Morishita, Kentaro Ishida, Kenichi Kaseno, Naoki Amaya, Hiroyasu Uzui, Hidehiko Okazawa, Hiroshi Tada
Journal of Nuclear Cardiology   24 1641-1650   Oct 2017   [Refereed]
© 2016, American Society of Nuclear Cardiology. Background: In successfully revascularized acute myocardial infarction (AMI), microvascular function in a myocardial flow-glucose metabolism mismatch pattern has not been reported. We aimed to elucid...
Hiroyuki Neishi, Masamichi Ikawa, Hidehiko Okazawa, Tetsuya Tsujikawa, Hidetaka Arishima, Ken Ichiro Kikuta, Makoto Yoneda
European Neurology   78 161-168   Sep 2017   [Refereed]
© 2017 S. Karger AG, Basel. All rights reserved. Background: This study sought to precisely evaluate striatal oxidative stress and its relationship with the disease severity in Parkinson's disease (PD) using double brain imaging,62Cu-diacetyl-bis ...
Hidenobu Yaku, Yoshio Yoshida, Hidehiko Okazawa, Yasushi Kiyono, Yuko Fujita, Daisuke Miyoshi
Analytical Chemistry   89 6948-6953   Jul 2017   [Refereed]
© 2017 American Chemical Society. A sensitive telomerase assay based on asymmetric-polymerase chain reaction (A-PCR) on magnetic beads and subsequent application of cycling probe technology, STAMC, which is insusceptible to DNase and PCR inhibitor...
Yoko Chino, Hideaki Tsuyoshi, Tetsuya Tsujikawa, Hidehiko Okazawa, Yoshio Yoshida
Clinical nuclear medicine   42    Jul 2017   [Refereed]
Intravenous leiomyomatosis is a life-threatening leiomyoma that grows into the extrauterine venous system. A high recurrence rate has been reported in reproductive-age women who undergo only tumor excision to preserve fertility. Precise diagnosis ...
Yuko Okamoto, Hirotaka Kosaka, Ryo Kitada, Ayumi Seki, Hiroki C. Tanabe, Masamichi J. Hayashi, Takanori Kochiyama, Daisuke N. Saito, Hisakazu T. Yanaka, Toshio Munesue, Makoto Ishitobi, Masao Omori, Yuji Wada, Hidehiko Okazawa, Tatsuya Koeda, Norihiro Sadato
Neuroscience Research   119 38-52   Jun 2017   [Refereed]
© 2017 Elsevier Ireland Ltd and Japan Neuroscience Society Individuals with autism spectrum disorder (ASD) have difficuly in recognizing bodies and faces, which are more pronounced in children than adults. If such difficulties originate from dysfu...
Koji Shimada, Takashi X. Fujisawa, Shinichiro Takiguchi, Hiroaki Naruse, Hirotaka Kosaka, Hidehiko Okazawa, Akemi Tomoda
World Journal of Biological Psychiatry   18 322-328   May 2017   [Refereed]
© 2015 Informa UK Limited, trading as Taylor & Francis Group. Objectives: Attention deficit/hyperactivity disorder (ADHD) is associated with deficits in the dopaminergic fronto-striatal systems mediating higher-level cognitive functions. We hypo...
Muhammad M. Islam, Tetsuya Tsujikawa, Tetsuya Mori, Yasushi Kiyono, Hidehiko Okazawa
Annals of Nuclear Medicine      May 2017   [Refereed]
G. M.Mahmudur Rahman, H. Okazawa, Md Sherajul Islam, Md Shahjahan, S. S. Zakir
ECCE 2017 - International Conference on Electrical, Computer and Communication Engineering   327-332   Apr 2017
© 2017 IEEE. Cerebrovascular disease (CVD) such as stroke is the leading cause of long-Term disability and the third most common reason of death in the world. In this work, an indication for the assessment of neuronal activity and the degree of se...
Tomoyo Morita, Daisuke N. Saito, Midori Ban, Koji Shimada, Yuko Okamoto, Hirotaka Kosaka, Hidehiko Okazawa, Minoru Asada, Eiichi Naito
Neuroscience   348 288-301   Apr 2017   [Refereed]
© 2017 The Author(s) Proprioception is somatic sensation that allows us to sense and recognize position, posture, and their changes in our body parts. It pertains directly to oneself and may contribute to bodily awareness. Likewise, one's face is ...
Islam MM, Tsujikawa T, Mori T, Kiyono Y, Okazawa H
Physics in Medicine and Biology   62 4514-4524   Mar 2017   [Refereed]
Makoto Yamamoto, Tetsuya Tsujikawa, Shizuka Yamada, Tetsuji Kurokawa, Akiko Shinagawa, Yoko Chino, Tetsuya Mori, Yasushi Kiyono, Hidehiko Okazawa, Yoshio Yoshida
Oncotarget   8 22581-22589   Jan 2017   [Refereed]
We investigated whether 16a-[18F]-fluoro-17β-estradiol (18F-FES) and18F-fluorodeoxyglucose (FDG) uptake measured using positron emission tomography (PET) predicted prognosis in 18 patients with different histological subtypes of uterine sarcoma. S...
Hiroshi Matsuda, Tomoya Uehara, Hidehiko Okazawa, Sunao Mizumura, Kunihiko Yokoyama, Mana Yoshimura
Kakuigaku   54 509-519   Jan 2017
© 2017 Japanese Society of Nuclear Medicine. This survey was performed to investigate the incidence of adverse reactions to radiopharmaceuticals in FY2015 in Japan. It was based on the responses to questionnaires sent to nuclear medicine instituti...
Makoto Isozaki, Yoshikazu Arai, Yoshifumi Higashino, Hidehiko Okazawa, Ken ichiro Kikuta
Annals of Nuclear Medicine   30 669-674   Nov 2016   [Refereed]
© 2016, The Japanese Society of Nuclear Medicine. A 64-year-old, right-handed man underwent endovascular treatment for internal carotid artery stenosis after experiencing a left-hemispheric transient ischemic attack.15O-gas and H215O positron emis...
H. Kosaka, Y. Okamoto, T. Munesue, H. Yamasue, K. Inohara, T. Fujioka, T. Anme, M. Orisaka, M. Ishitobi, M. Jung, T. X. Fujisawa, S. Tanaka, S. Arai, Asano, D. N. Saito, N. Sadato, A. Tomoda, M. Omori, M. Sato, M. Sato, H. Okazawa, H. Higashida, Y. Wada
Translational psychiatry   6    Aug 2016   [Refereed]
Recent studies have suggested that long-term oxytocin administration can alleviate the symptoms of autism spectrum disorder (ASD); however, factors influencing its efficacy are still unclear. We conducted a single-center phase 2, pilot, randomized...
Tomoyo Morita, Hirotaka Kosaka, Daisuke N. Saito, Takeshi Fujii, Makoto Ishitobi, Toshio Munesue, Keisuke Inohara, Hidehiko Okazawa, Ryusuke Kakigi, Norihiro Sadato
Research in Autism Spectrum Disorders   26 16-32   Jun 2016   [Refereed]
When exposed to self-face images, individuals often experience embarrassment, which is enhanced by being observed. This self-evaluative emotion is related to activity in the right anterior insula and the functional connectivity between the anterio...
Tetsuya Tsujikawa, Hirohiko Kimura, Tsuyoshi Matsuda, Yasuhiro Fujiwara, Yasuhiro Fujiwara, Makoto Isozaki, Ken Ichiro Kikuta, Hidehiko Okazawa
PLoS ONE   11(6) e0156005   Jun 2016   [Refereed]
© 2016 Tsujikawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source a...
Tetsuya Tsujikawa, Satoko Asahi, Myungmi Oh, Yoshitaka Sato, Norihiko Narita, Akira Makino, Tetsuya Mori, Yasushi Kiyono, Tatsuro Tsuchida, Hirohiko Kimura, Shigeharu Fujieda, Hidehiko Okazawa
PLoS ONE   11(5) e0155635   May 2016   [Refereed]
© 2016 Tsujikawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source a...
Makoto Yamamoto, Tetsuya Tsujikawa, Yuko Fujita, Yoko Chino, Tetsuji Kurokawa, Yasushi Kiyono, Hidehiko Okazawa, Yoshio Yoshida
Cancer Science   107 478-485   Apr 2016   [Refereed]
© 2016 Japanese Cancer Association. Volumetric parameters of positron emission tomography-computed tomography using 18F-fludeoxyglucose (18F-FDG PET/CT) that comprehensively reflect both metabolic activity and tumor burden are capable of predictin...
Tasmiah Rahman, Tetsuya Tsujikawa, Makoto Yamamoto, Yoko Chino, Akiko Shinagawa, Tetsuji Kurokawa, Tatsuro Tsuchida, Hirohiko Kimura, Yoshio Yoshida, Hidehiko Okazawa
Medicine (United States)   95(9) e3017   Mar 2016   [Refereed]
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This study aimed to investigate whether the predictive values of intensity-and volume-based PET parameters are different between histological subtypes in patients with cervical canc...
Toru Fujioka, Keisuke Inohara, Yuko Okamoto, Yasuhiro Masuya, Makoto Ishitobi, Daisuke N. Saito, Minyoung Jung, Sumiyoshi Arai, Yukiko Matsumura, Takashi X. Fujisawa, Kosuke Narita, Katsuaki Suzuki, Kenji J. Tsuchiya, Norio Mori, Taiichi Katayama, Makoto Sato, Toshio Munesue, Hidehiko Okazawa, Akemi Tomoda, Yuji Wada, Hirotaka Kosaka
Molecular Autism   7    Jan 2016   [Refereed]
© 2016 Fujioka et al. Background: Gaze abnormality is a diagnostic criterion for autism spectrum disorder (ASD). However, few easy-to-use clinical tools exist to evaluate the unique eye-gaze patterns of ASD. Recently, we developed Gazefinder, an a...
Hiroshi Matsuda, Yasushi Arano, Hidehiko Okazawa, Sunao Mizumura, Kunihiko Yokoyama, Mana Yoshimura
Kakuigaku   53 9-20   Jan 2016
This survey was performed in order to investigate the incidence of adverse reactions to radiopharmaceuticals in FY2014 in Japan. It was based on the responses to questionnaires sent to nuclear medicine institutions. The reply was obtained from 992...
Yukihiro Umeda, Yoshiki Demura, Miwa Morikawa, Masaki Anzai, Maiko Kadowaki, Shingo Ameshima, Tatsuro Tsuchida, Tetsuya Tsujikawa, Yasushi Kiyono, Hidehiko Okazawa, Takeshi Ishizaki, Tamotsu Ishizuka
Journal of Nuclear Medicine   56(12) 1869-1875   Dec 2015   [Refereed]
© 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc. The aim of this prospective study was to clarify whether dual-timepoint18F-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF...
Minyoung Jung, Maria Mody, Daisuke N. Saito, Akemi Tomoda, Hidehiko Okazawa, Yuji Wada, Hirotaka Kosaka
PLoS ONE   10(11) e0143126   Nov 2015   [Refereed]
© 2015 Jung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr...
Koji Shimada, Koji Shimada, Koji Shimada, Shinichiro Takiguchi, Sakae Mizushima, Takashi X. Fujisawa, Takashi X. Fujisawa, Daisuke N. Saito, Daisuke N. Saito, Daisuke N. Saito, Hirotaka Kosaka, Hirotaka Kosaka, Hirotaka Kosaka, Hidehiko Okazawa, Hidehiko Okazawa, Akemi Tomoda, Akemi Tomoda
NeuroImage: Clinical   9 13-19   Aug 2015   [Refereed]
© 2015 The Authors. Published by Elsevier Inc. Child maltreatment increases the risk for psychiatric disorders throughout childhood and into adulthood. One negative outcome of child maltreatment can be a disorder of emotional functioning, reactive...
Kazunobu Tsuji, Shinji Kishi, Tatsuro Tsuchida, Takahiro Yamauchi, Satoshi Ikegaya, Yoshimasa Urasaki, Yasuhiro Fujiwara, Takanori Ueda, Hidehiko Okazawa, Hirohiko Kimura
Journal of Magnetic Resonance Imaging   41 1601-1607   Jun 2015   [Refereed]
© 2014 Wiley Periodicals, Inc. Background: To examine the utility of diffusion-weighted MRI (DW-MRI) for staging and early response to chemotherapy assessment in lymphoma patients as compared with fluorodeoxyglucose positron emission tomography/co...
Hironori Mitsuya, Naoto Omata, Yasushi Kiyono, Tomoyuki Mizuno, Tetsuhito Murata, Kayo Mita, Hidehiko Okazawa, Yuji Wada
Behavioural Brain Research   284 125-130   May 2015   [Refereed]
© 2015 The Authors. Nutritional and social environmental problems during the early stages of life are closely associated with the pathophysiology of mood disorders such as depression. Disruption or dysfunction of the central norepinephrine (NE) sy...
Hidetsugu Komeda, Hirotaka Kosaka, Hirotaka Kosaka, Hirotaka Kosaka, Hirotaka Kosaka, Hirotaka Kosaka, Hirotaka Kosaka, Hirotaka Kosaka, Daisuke N. Saito, Daisuke N. Saito, Daisuke N. Saito, Daisuke N. Saito, Daisuke N. Saito, Daisuke N. Saito, Daisuke N. Saito, Yoko Mano, Minyoung Jung, Minyoung Jung, Minyoung Jung, Minyoung Jung, Minyoung Jung, Takeshi Fujii, Takeshi Fujii, Takeshi Fujii, Hisakazu T. Yanaka, Toshio Munesue, Makoto Ishitobi, Makoto Ishitobi, Makoto Sato, Makoto Sato, Makoto Sato, Makoto Sato, Makoto Sato, Makoto Sato, Makoto Sato, Hidehiko Okazawa, Hidehiko Okazawa
Social Cognitive and Affective Neuroscience   10(2) 145-152   Feb 2015   [Refereed]
© 2014 The Author. Individuals with autism spectrum disorder (ASD) are thought to lack self-awareness and to experience difficulty empathizing with others. Although these deficits have been demonstrated in previous studies, most of the target stim...
Hiroshi Matsuda, Yasushi Arano, Hidehiko Okazawa, Sunao Mizumura, Kunihiko Yokoyama, Mana Yoshimura
Kakuigaku   52 1-12   Jan 2015
This survey was performed in order to investigate the incidence of adverse reactions to radiopharmaceu-ticals in FY2013 in Japan. It was based on responses to questionnaires sent to nuclear medicine institutions. The reply was obtained from 997 in...
Minyoung Jung, Hirotaka Kosaka, Hirotaka Kosaka, Hirotaka Kosaka, Hirotaka Kosaka, Daisuke N. Saito, Daisuke N. Saito, Makoto Ishitobi, Makoto Ishitobi, Tomoyo Morita, Keisuke Inohara, Mizuki Asano, Mizuki Asano, Sumiyoshi Arai, Toshio Munesue, Toshio Munesue, Akemi Tomoda, Akemi Tomoda, Yuji Wada, Yuji Wada, Norihiro Sadato, Norihiro Sadato, Hidehiko Okazawa, Hidehiko Okazawa, Tetsuya Iidaka
Molecular Autism   5 35   Jun 2014   [Refereed]
Background: Autism spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development (TD). Social cognition properties that are deeply associated with autism spectrum traits ...
Takeshi Fujii, Takeshi Fujii, Takeshi Fujii, Daisuke N. Saito, Daisuke N. Saito, Daisuke N. Saito, Hisakazu T. Yanaka, Hisakazu T. Yanaka, Hisakazu T. Yanaka, Hirotaka Kosaka, Hirotaka Kosaka, Hidehiko Okazawa, Hidehiko Okazawa, Hidehiko Okazawa
Hippocampus   24(2) 212-224   Feb 2014   [Refereed]
Although patients with major depressive disorder typically have a reduced hippocampal volume, particularly in the cornu ammonis 1 (CA1), animal studies suggest that depressive mood is related to the dentate gyrus (DG). In this study, our objective...
Tomoko Muramatsu, Masamichi Ikawa, Makoto Yoneda, Katsuya Sugimoto, Akiko Matsunaga, Osamu Yamamura, Tadanori Hamano, Hidehiko Okazawa, Yasunari Nakamoto
European Neurology   72(1-2) 13-19   Jan 2014   [Refereed]
Background: The aim of this study was to evaluate the changes in regional cerebral blood flow (rCBF) in multiple cases of Hashimoto's encephalopathy (HE). Methods: Seven untreated patients with HE and 10 age-matched healthy controls underwent brai...
Yuko Okamoto, Yuko Okamoto, Yuko Okamoto, Ryo Kitada, Ryo Kitada, Hiroki C. Tanabe, Hiroki C. Tanabe, Masamichi J. Hayashi, Masamichi J. Hayashi, Masamichi J. Hayashi, Masamichi J. Hayashi, Takanori Kochiyama, Toshio Munesue, Makoto Ishitobi, Makoto Ishitobi, Daisuke N. Saito, Daisuke N. Saito, Daisuke N. Saito, Hisakazu T. Yanaka, Hisakazu T. Yanaka, Hisakazu T. Yanaka, Masao Omori, Yuji Wada, Yuji Wada, Hidehiko Okazawa, Hidehiko Okazawa, Hidehiko Okazawa, Akihiro T. Sasaki, Akihiro T. Sasaki, Akihiro T. Sasaki, Akihiro T. Sasaki, Tomoyo Morita, Tomoyo Morita, Shoji Itakura, Shoji Itakura, Hirotaka Kosaka, Hirotaka Kosaka, Hirotaka Kosaka, Norihiro Sadato, Norihiro Sadato, Norihiro Sadato
Neuroscience Research   87 66-76   Jan 2014   [Refereed]
© 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. Detection of the contingency between one's own behavior and consequent social events is important for normal social development, and impaired contingency detection may be a cause of a...
Yoshitaka Sato, Yoshitaka Sato, Tetsuya Tsujikawa, Myungmi Oh, Tetsuya Mori, Yasushi Kiyono, Shigeharu Fujieda, Hirohiko Kimura, Hidehiko Okazawa
Clinical Nuclear Medicine   39(12) 1027-1032   Jan 2014   [Refereed]
Copyright © 2014 Lippincott Williams & Wilkins. Purpose: The aim of this study was to investigate the potential of PET imaging with a hypoxia-selective tracer62Cu-diacetyl-bis(N4-methylthiosemicarbazone) (62Cu-ATSM) for evaluating the prognosis ...
Naoto Omata, Tomoyuki Mizuno, Tomoyuki Mizuno, Hironori Mitsuya, Kayo Mita, Yoshie Higashi, Tetsuro Kamichika, Yasushi Kiyono, Hidehiko Okazawa, Yuji Wada
Medical Hypotheses   83 845-846   Jan 2014   [Refereed]
Hiroshi Matsijda, Yasushi Arano, Hidehiko Okazawa, Sunao Mizijmura, Kunihiko Yokoyama, Mana Yoshimura
Kakuigaku   51 1-12   Jan 2014   [Refereed]
This survey was performed in order to investigate the incidence of adverse reactions to radiopharmaceuticals in FY2012 in Japan. It was based on responses to questionnaires sent to nuclear medicine institutions. The reply was obtained from 977 ins...
Yoshitomo Fukuoka, Akira Nakano, Akira Nakano, Hiroyasu Uzui, Naoki Amaya, Kentaro Ishida, Kenichiro Arakawa, Takashi Kudo, Hidehiko Okazawa, Takanori Ueda, Jong Dae Lee, Hiroshi Tada
European Journal of Nuclear Medicine and Molecular Imaging   40(8) 1155-1162   Aug 2013   [Refereed]
Purpose: Positron emission tomography (PET) with18F- fluorodeoxyglucose (FDG) has been reported to be unreliable for identifying viable myocardium in acute myocardial infarction (AMI), especially in areas with discordance in myocardial blood flow ...
Tomoyuki Mizuno, Naoto Omata, Tetsuhito Murata, Tetsuhito Murata, Hironori Mitsuya, Nobuyuki Maruoka, Kayo Mita, Yasushi Kiyono, Hidehiko Okazawa, Hiroshi Ikeda, Yuji Wada
Medical Hypotheses   81(2) 175-9   Aug 2013   [Refereed]
What underlies bipolar disorder? What pathophysiologic process can produce symptoms that are apparently polar opposites? Recent studies of neuronal plasticity suggest a mechanism. Both zinc deficiency and social isolation impair neuronal plasticit...
Hideaki Tsuyoshi, Fumiko Morishita, Makoto Orisaka, Hidehiko Okazawa, Yoshio Yoshida
Clinical Nuclear Medicine   38(7) 560-3   Jul 2013   [Refereed]
In order to establish early and precise methods for evaluating the effect of secondary chemotherapy in patients with recurrent ovarian cancer, both the clinical course of 3 women treated with gemcitabine-based secondary chemotherapy and the potent...
Tatsuro Tsuchida, Miwa Morikawa, Yoshiki Demura, Yoshiki Demura, Yukihiro Umeda, Hidehiko Okazawa, Hirohiko Kimura
Journal of Magnetic Resonance Imaging   38(1) 80-88   Jul 2013   [Refereed]
Purpose To evaluate the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) for assessment of the early response to chemotherapy and outcome in patients with advanced lung cancer through comparison with fluorine-18 fluorodeoxyglu...
Kenzo Uchida, Hideaki Nakajima, Tsuyoshi Miyazaki, Tatsuro Tsuchida, Takayuki Hirai, Daisuke Sugita, Shuji Watanabe, Naoto Takeura, Ai Yoshida, Hidehiko Okazawa, Hisatoshi Baba
Asian Spine Journal   7(2) 96-103   Jun 2013   [Refereed]
Study Design: A retrospective study. Purpose: The aims of this study were to investigate the diagnostic value of18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in PET/computed tomography (CT) in the evaluation of spinal metastatic ...
Zhenhua Zhao, Yoshio Yoshida, Tetsuji Kurokawa, Yasushi Kiyono, Tetsuya Mori, Hidehiko Okazawa
Journal of Nuclear Medicine   54(4) 499-506   Apr 2013   [Refereed]
The aim of this study was to investigate the relationship between the tumor uptake of 16α-18F-fluoro-17β-estradiol (18F-FES) and18F-FDG using PET and expressions of sex hormone receptors, such as estrogen receptor (ER), as well as glucose transpor...
Nobuyuki Maruoka, Tetsuhito Murata, Naoto Omata, Hironori Mitsuya, Yasushi Kiyono, Hidehiko Okazawa, Yuji Wada
Journal of Neural Transmission   120(3) 375-382   Mar 2013   [Refereed]
Ammonia, which is considered to be the main agent responsible for hepatic encephalopathy, inhibits oxidative glucose metabolism in the brain. However, the effects of ammonia on cerebral glucose metabolism in different brain regions remains unclear...
Nobuyuki Oyama, Hideaki Ito, Yoshitaka Aoki, Yoshiji Miwa, Hironobu Akino, Takashi Kudo, Takashi Kudo, Hidehiko Okazawa, Yasuhisa Fujibayashi, Yasuhisa Fujibayashi, Michael J. Welch, Michael J. Welch, Michael J. Welch, Osamu Yokoyama
Hellenic Journal of Nuclear Medicine   16(2) 146-147   Jan 2013   [Refereed]
Hiroshi Matsuda, Yasushi Arano, Hidehiko Okazawa, Sunao Mizumura, Kunihiko Yokoyama, Mana Yoshimura
Kakuigaku   50 25-33   Jan 2013
This survey was performed in order to investigate the incidence of adverse reactions to radiopharmaceuticals in FY2011 in Japan. It was based on responses to questionnaires sent to nuclear medicine institutions. The reply was obtained from 999 ins...
Naoto Omata, Tetsuhito Murata, Nobuyuki Maruoka, Hiroshi Ikeda, Hironori Mitsuya, Tomoyuki Mizuno, Kayo Mita, Mizuki Asano, Yasushi Kiyono, Hidehiko Okazawa, Yuji Wada
Neuroscience Letters   531(1) 10-13   Nov 2012   [Refereed]
Deficiency of zinc, which modulates glutamate release, might increase ischemic vulnerability of the brain. We examined effects of dietary zinc deficiency for 2 weeks on ischemic vulnerability in several brain regions using dynamic positron autorad...
Masato Kobayashi, Masato Kobayashi, Fumiya Hashimoto, Kazuyo Ohe, Takahiro Nadamura, Kodai Nishi, Naoto Shikano, Ryuichi Nishii, Tatsuya Higashi, Hidehiko Okazawa, Keiichi Kawai, Keiichi Kawai
Nuclear Medicine and Biology   39(8) 1213-1218   Nov 2012   [Refereed]
Introduction: S-methyl-11C-labeled l- and d-methionine (11C-l- and d-MET) are useful as radiotracers for tumor imaging. However, it is not known whether the transport mechanism of11C-d-MET is the same as that for11C-l-MET, which is transported by ...
Kenzo Uchida, Hideaki Nakajima, Hidehiko Okazawa, Hirohiko Kimura, Takashi Kudo, Shuji Watanabe, Ai Yoshida, Hisatoshi Baba
European Journal of Nuclear Medicine and Molecular Imaging   39(10) 1528-1537   Oct 2012   [Refereed]
Purpose18F-FDG PET is used to investigate the metabolic activity of neural tissue. MRI is used to visualize morphological changes, but the relationship between intramedullary signal changes and clinical outcome remains controversial. The present s...
Hiroki C. Tanabe, Hiroki C. Tanabe, Hiroki C. Tanabe, Hirotaka Kosaka, Hirotaka Kosaka, Hirotaka Kosaka, Daisuke N. Saito, Takahiko Koike, Masamichi J. Hayashi, Masamichi J. Hayashi, Keise Izuma, Keise Izuma, Hidetsugu Komeda, Makoto Ishitobi, Masao Omori, Toshio Munesue, Hidehiko Okazawa, Hidehiko Okazawa, Yuji Wada, Yuji Wada, Norihiro Sadato, Norihiro Sadato, Norihiro Sadato
Frontiers in Human Neuroscience   6(268) 1-15   Sep 2012   [Refereed]
Persons with autism spectrum disorders (ASD) are known to have difficulty in eye contact (EC). This may make it difficult for their partners during face to face communication with them. To elucidate the neural substrates of live inter-subject inte...
Y. Kiyono, Y. Kiyono, T. Mori, H. Okazawa, H. Okazawa
Current Medicinal Chemistry   19(20) 3266-3270   Jul 2012   [Refereed]
Understanding the expression of tumor specific receptors is important not only for tumor diagnosis but also for planning the strategy for patient treatment. Tumor receptor has been one of the most critical targets for treatment in cancer such as b...

Misc

 
H.Matsuda, Y.Arano, H.Okazawa, T.Okamura, S.Mizumura, K.Yokoyama
Kaku Igaku (Jpn J Nucl Med)   49(1) 1-14   Feb 2012
This survey was performed in order to investigate the incidence of adverse reactions to radiopharmaceuticals in FY2010 in Japan. It was based on responses to questionnaires sent to nuclear medicine institutions. The reply was obtained from 961 ins...
Shigeyuki Wakahara, Tadashi Konoshita, Ai Sakai, Takahiro Nakaya, Mai Ichikawa, Katsushi Yamamoto, Michiko Imagawa, Hirohiko Kimura, Hidehiko Okazawa, Tamotsu Ishizuka, Yiyan Liu
Medicine (United States)   94    Jan 2015
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. A 55-year-old woman was referred for a suspicion of mediastinal tumor through plain X-ray photography (X-P). Magnetic resonance imaging (MRI) revealed a 3cm diameter tumor which see...
Masamichi Ikawa, Hidehiko Okazawa, Tetsuya Tsujikawa, Akiko Matsunaga, Osamu Yamamura, Tetsuya Mori, Tadanori Hamano, Yasushi Kiyono, Yasunari Nakamoto, Makoto Yoneda, Makoto Yoneda
Neurology   84 2033-2039   Jan 2015
© 2015 American Academy of Neurology. To investigate cerebral oxidative stress based on an over-reductive state caused by mitochondrial dysfunction and its relationship to disease severity in patients with amyotrophic lateral sclerosis (ALS) using...
Masato Kobayashi, Tetsuya Mori, Tetsuya Tsujikawa, Kazuhiro Ogai, Jyunko Sugama, Yasushi Kiyono, Keiichi Kawai, Keiichi Kawai, Hidehiko Okazawa
Hellenic Journal of Nuclear Medicine   18 103-107   Jan 2015
© 2015, P.Ziti and Co. All rights reserved. Objective: PET imaging is possible with copper (Cu) isotopes, 60Cu, 61Cu, 62Cu and 64Cu. Although 62Cu- and 64Cu-labeled radiotracers are...
Chao Lin, Kyo Kume, Tetsuya Mori, Miguel E. Martinez, Hidehiko Okazawa, Yasushi Kiyono, Yasushi Kiyono
Journal of Nuclear Medicine   56 945-950   Jan 2015
The aim of this study was to investigate whether 3'-deoxy-3'-18Ffluorothymidine (18F-FLT) can monitor the early response of tumor cell proliferation to charged particle irradiation in vitro and in vivo. Methods: In vitro, aft...

Books etc

 
Serial Review on Clinical PET Tracers(Part:Contributor, Measurement of Cerebral Blood Flow Using H215O PET and Its Clinical Application)
Japan Radioisotope Association   2010   ISBN:978-4-89073-207-4
Quantitation in Biomedical Imaging with PET and MRI(Part:Contributor, Measurement of arterial part of vascular volume (V0) for the evaluation of hemodynamic changes in cerebrovascular disease.)
Elsevier   2004   ISBN:0444515674
Brain Imaging Using PET(Part:Contributor, Delay and dispersion correction for a new coincidential radioactivity detector, Pico-Count, in quantitative PET studies.)
Academic Press, San Diego   2002   

Conference Activities & Talks

 
Feasibility of pulsed continuous arterial spin labeling (pCASL) in quantitative evaluation of cerebral blood flow: Comparison with quantitative SPECT and PET
EANM2014 (European Association of Nuclear Medicine)   2014   
Hypoxic volume measurement using Cu-ATSM PET may be a predictive index for prognosis of advanced head-and-neck cancers: Comparison with FDG-PET.
World Molecular Imaging Conference   2014   
Evaluation of cerebral oxidative stress in amyotrophic lateral sclerosis using 62Cu-ATSM PET.
The 61st Annual Meeting of The Society of Nuclear Medicine   2014   
Being observed do not modulate self-conscious emotion in autism spectrum disorders.
International Workshop on Molecular Functional Imaging   2014   
Neural substrates of contingency detection for self and other in individuals with autism spectrum disorder: an fMRI study.
International Workshop on Molecular Functional Imaging   2014   

Research Grants & Projects

 
Nuclear oncology
Grant-in-Aid for Scientific Research
Project Year: 2009 - 2015
Brain functional imaging on brain development and related psychiatric disorders.
Project Year: 2009 - 2014
ヒトの脳の発達および発達障害を伴った精神疾患、その他の精神疾患を対象としたfMRI, PETによる脳機能イメージング研究
Study of hemodynamics in patients with CVD (basic & Clinical)
Grant-in-Aid for Scientific Research
Project Year: 2003 - 2012
Study of CBF autoregulation in ischemic condition
Grant-in-Aid for Scientific Research
Project Year: 2003 - 2006