2007年11月
Dynamically Sliding Threshold Model Reproduces the Initial-Strength Dependence of Spike-Timing Dependent Synaptic Plasticity
Journal of the Physical Society of Japan
- ,
- 巻
- 76
- 号
- 11
- 開始ページ
- 114802(1)
- 終了ページ
- 114802(7)
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1143/JPSJ.76.114802
- 出版者・発行元
- PHYSICAL SOC JAPAN
It has been considered that an amount of calcium elevation in a synaptic spine determines whether the synapse is potentiated or depressed. However, it has been pointed out that simple application of the principle can not reproduce properties of spike-timing-dependent plasticity (STDP). To solve the problem, we present a possible mechanism using dynamically sliding threshold determined as the linear summation of calcium elevations induced by single pre- and post-synaptic spikes. We demonstrate that the model can reproduce the timing dependence of biological STDP. In addition, we find that the model can reproduce the dependence of biological STDP on the initial synaptic strength, which is found to be asymmetric for synaptic potentiation and depression, whereas no explicit initial-strength dependence nor asymmetric mechanism are incorporated into the model.
- リンク情報
- ID情報
-
- DOI : 10.1143/JPSJ.76.114802
- ISSN : 0031-9015
- Web of Science ID : WOS:000251121900067