2018年3月5日
Glucose Responsive Rheological Change and Drug Release from a Novel Worm-like Micelle Gel Formed in Cetyltrimethylammonium Bromide/Phenylboronic Acid/Water System
Molecular Pharmaceutics
- 巻
- 15
- 号
- 3
- 開始ページ
- 1097
- 終了ページ
- 1104
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.molpharmaceut.7b00988
© 2018 American Chemical Society. A novel glucose (Glc)-responsive gel formed by worm-like micelles (WLMs) has the potential to provide a self-regulating insulin delivery system. We have prepared a WLM gel system using 75 mM cetyltrimethylammonium bromide, 75 mM phenylboronic acid, and water. At pH 9.4, this gel-like system was highly viscous and supported its own weight, and dynamic viscoelasticity measurement indicated that it contained long and entangled WLMs. The visual observation of gels prepared to include >6 mM Glc revealed that these adopted a sol-like appearance, whereas those prepared to include a control compound (2-10 mM diethylene glycol) retained their gel-like appearance. The storage modulus (G′) of this system decreased as the Glc concentration increased (2-10 mM), indicating a gradual shortening of the WLMs. In vitro release was evaluated using a test compound (fluorescein isothiocyanate dextran) in a microsized flow system. By 120 min, the release of this compound from the WLM gel was around 27-fold greater in the presence of 100 mM Glc than without Glc or with 100 mM diethylene glycol. This demonstrated the successful preparation of a WLM gel that showed an altered drug release rate, depending on Glc concentration.
- リンク情報
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- DOI
- https://doi.org/10.1021/acs.molpharmaceut.7b00988
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29411982
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042923663&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85042923663&origin=inward
- ID情報
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- DOI : 10.1021/acs.molpharmaceut.7b00988
- ISSN : 1543-8384
- eISSN : 1543-8392
- PubMed ID : 29411982
- SCOPUS ID : 85042923663