Sato, Toshiro

J-GLOBAL         Last updated: May 29, 2019 at 03:01
 
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Name
Sato, Toshiro
Affiliation
Keio University
Section
School of Medicine The Sakaguchi Laboratory - Department of Organoid Medicine
Job title
Professor (Non-tenured)
Degree
博士(医学)慶應義塾大学大学院医学研究科(Keio University)
Research funding number
70365245

Academic & Professional Experience

 
Apr 1997
 - 
Mar 2003
内科研修医, 慶應義塾大学病院
 
Apr 2003
 - 
Today
内科専修医, 慶應義塾大学病院
 
Sep 2004
 - 
Today
COE特別研究員, 慶應義塾大学病院
 
Sep 2005
 - 
Today
医員, 消化器内科, 東京電力病院
 
Apr 2006
 - 
Today
博士研究員, Stowers研究所(米国)
 

Education

 
Mar 1997
   
 
医学部, Keio University
 
Mar 2003
   
 
大学院医学研究科, Keio University
 

Awards & Honors

 
2011
日本消化器病学会研究助成賞, The Japanese Society of Gastroenterology
 
2011
慶應義塾大学医学部三四会 三四会奨励賞, Keio University School of Medicine, Sanshikai
 
2011
第19回浜名湖シンポジウム 最優秀演題賞
 
2012
大腸の癌化における必須遺伝子変異の同定, 井上リサーチアウォード, 公益財団法人井上科学振興財団
 
2012
消化管上皮幹細胞の新規培養法を用いた自己複製機構の研究, 文部科学大臣表彰 若手科学者賞, 文部科学省
 

Published Papers

 
Nakamoto N., Sasaki N., Aoki R., Miyamoto K., Suda W., Teratani T., Suzuki T., Koda Y., Chu P., Taniki N., Yamaguchi A., Kanamori M., Kamada N., Hattori M., Ashida H., Sakamoto M., Atarashi K., Narushima S., Yoshimura A., Honda K., Sato T., Kanai T.
Nature Microbiology   4(3) 492-503   Mar 2019
© 2019, The Author(s), under exclusive licence to Springer Nature Limited. Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent complication with ulcerative colitis highlights the pathogenic role of epithe...
Fujii M., Clevers H., Sato T.
Gastroenterology   156(3) 562-576   Feb 2019
© 2019 AGA Institute Insights into the stem cell niche have allowed researchers to cultivate adult tissue stem cells as organoids that display structural and phenotypic features of healthy and diseased epithelial tissues. Organoids derived from pa...
Fujii M., Matano M., Toshimitsu K., Takano A., Mikami Y., Nishikori S., Sugimoto S., Sato T.
Cell Stem Cell   23(6) 787-793.e6   Dec 2018
© 2018 Elsevier Inc. Cellular diversity that shapes tissue architecture and function is governed by multiple niche signals. Nonetheless, maintaining cellular diversity in human intestinal organoids has been challenging. Based on niche ligands pres...
Saito Yoshimasa, Nakaoka Toshiaki, Muramatsu Toshihide, Ojima Hidenori, Sukeda Aoi, Sugiyama Yuko, Uchida Ryoei, Furukawa Ryo, Kitahara Aya, Sato Toshiro, Kanai Yae, Saito Hidetsugu
Scientific Reports   8(1)    Dec 2018   [Refereed]
<p>Intrahepatic cholangiocarcinoma (IHCC) is a highly aggressive malignancy with a poor prognosis. It is thought to originate from cholangiocytes, which are the component cells of intrahepatic bile ducts. However, as patients with viral hepatitis ...
Nanki Kosaku, Toshimitsu Kohta, Takano Ai, Fujii Masayuki, Shimokawa Mariko, Ohta Yuki, Matano Mami, Seino Takashi, Nishikori Shingo, Ishikawa Keiko, Kawasaki Kenta, Togasaki Kazuhiro, Takahashi Sirirat, Sukawa Yasutaka, Ishida Hiroki, Sugimoto Shinya, Kawakubo Hirofumi, Kim Jihoon, Kitagawa Yuko, Sekine Shigeki, Koo Bon Kyoung, Kanai Takanori, Sato Toshiro
Cell   174(4) 856-869.e17   Aug 2018   [Refereed]
<p>Recent sequencing analyses have shed light on heterogeneous patterns of genomic aberrations in human gastric cancers (GCs). To explore how individual genetic events translate into cancer phenotypes, we established a biological library consistin...
Loomans Cindy J.M., Williams Giuliani Nerys, Balak Jeetindra, Ringnalda Femke, van Gurp Léon, Huch Meritxell, Boj Sylvia F., Sato Toshiro, Kester Lennart, de Sousa Lopes Susana M.Chuva, Roost Matthias S., Bonner-Weir Susan, Engelse Marten A., Rabelink Ton J., Heimberg Harry, Vries Robert G.J., van Oudenaarden Alexander, Carlotti Françoise, Clevers Hans, de Koning Eelco J.P.
Stem Cell Reports   10(3) 1088-1101   Mar 2018   [Refereed]
<p>Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. Here, we describe a 3D culture system that supports the expansion of adult human pancreatic tissue and the gen...
Kawasaki K., Fujii M., Sato T.
Disease models & mechanisms   11(2)    Feb 2018
© 2018. Published by The Company of Biologists Ltd. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) refer to a group of heterogeneous cancers of neuroendocrine cell phenotype that mainly fall into one of two subtypes: gastroenteropancre...
Sugimoto Shinya, Ohta Yuki, Fujii Masayuki, Matano Mami, Shimokawa Mariko, Nanki Kosaku, Date Shoichi, Nishikori Shingo, Nakazato Yoshihiro, Nakamura Tetsuya, Kanai Takanori, Sato Toshiro
Cell Stem Cell   22(2) 171-176.e5   Feb 2018
<p>Genetic lineage tracing has revealed that Lgr5+ murine colon stem cells (CoSCs) rapidly proliferate at the crypt bottom. However, the spatiotemporal dynamics of human CoSCs in vivo have remained experimentally intractable. Here we es...
Kanaya Takashi, Sakakibara Sayuri, Jinnohara Toshi, Hachisuka Masami, Tachibana Naoko, Hidano Shinya, Kobayashi Takashi, Kimura Shunsuke, Iwanaga Toshihiko, Nakagawa Tomoo, Katsuno Tatsuro, Kato Naoya, Akiyama Taishin, Sato Toshiro, Williams Ifor R., Ohno Hiroshi
Journal of Experimental Medicine   215(2) 501-519   Feb 2018   [Refereed]
<p>M cells are located in the follicle-associated epithelium (FAE) that covers Peyer's patches (PPs) and are responsible for the uptake of intestinal antigens. The differentiation of M cells is initiated by receptor activator of NF-κB. However, th...
Mito Akiko, Nakano Yukiko, Saitoh Takako, Gouraud Sabine S.S., Yamaguchi Yoshiki, Sato Toshiro, Sasaki Nobuo, Kojima-Aikawa Kyoko
Glycobiology   28(1) 21-31   Jan 2018   [Refereed]
<p>Zymogen granule protein 16 (ZG16p) is a soluble lectin that binds to both mannose and heparin/ heparan sulfate. It is highly expressed in the human digestive tract and is secreted into the mucus. In this study, we investigated the effect of ZG1...
Seino Takashi, Kawasaki Shintaro, Shimokawa Mariko, Tamagawa Hiroki, Toshimitsu Kohta, Fujii Masayuki, Ohta Yuki, Matano Mami, Nanki Kosaku, Kawasaki Kenta, Takahashi Sirirat, Sugimoto Shinya, Iwasaki Eisuke, Takagi Junichi, Itoi Takao, Kitago Minoru, Kitagawa Yuko, Kanai Takanori, Sato Toshiro
Cell Stem Cell   22(3) 454-467   Jan 2018   [Refereed]
<p>Despite recent efforts to dissect the inter-tumor heterogeneity of pancreatic ductal adenocarcinoma (PDAC) by determining prognosis-predictive gene expression signatures for specific subtypes, their functional differences remain elusive. Here, ...
Nakamura Tetsuya, Sato Toshiro
CMGH   5(1) 51-60   Jan 2018   [Refereed]
<p>With the emergence of technologies to culture intestinal epithelial cells in vitro as various forms of intestinal organoids, there is growing interest in using such cultured intestinal cells as a source for tissue engineering and regenerative m...
Hayashi Atsushi, Mikami Yohei, Miyamoto Kentaro, Kamada Nobuhiko, Sato Toshiro, Mizuno Shinta, Naganuma Makoto, Teratani Toshiaki, Aoki Ryo, Fukuda Shinji, Suda Wataru, Hattori Masahira, Amagai Masayuki, Ohyama Manabu, Kanai Takanori
Cell Reports   20(7) 1513-1524   Aug 2017
Metabolism by the gut microbiota affects host physiology beyond the gastrointestinal tract. Here, we find that antibiotic-induced dysbiosis, in particular, overgrowth of Lactobacillus murinus (L. murinus), impaired gut metabolic function and led t...
Fujii Masayuki, Sato Toshiro
Genome Medicine   9(1)    Jul 2017
Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid techn...
Sugimoto Shinya, Sato Toshiro
Methods in Molecular Biology   1612 97-105   Jun 2017   [Refereed]
<p>The intestinal epithelium is the most rapidly renewed tissue in adult mammals, and its renewal is strictly controlled by intestinal stem cells. Extensive studies using genetic models of intestinal epithelium have revealed the mechanisms underly...
Jinnohara Toshi, Kanaya Takashi, Hase Koji, Sakakibara Sayuri, Kato Tamotsu, Tachibana Naoko, Sasaki Takaharu, Hashimoto Yusuke, Sato Toshiro, Watarai Hiroshi, Kunisawa Jun, Shibata Naoko, Williams Ifor R., Kiyono Hiroshi, Ohno Hiroshi
Journal of Experimental Medicine   214(6) 1607-1618   Jun 2017
Interleukin-22 (IL-22) acts protectively and harmfully on intestinal tissue depending on the situation; therefore, IL-22 signaling needs to be tightly regulated. IL-22 binding protein (IL-22BP) binds IL-22 to inhibit IL-22 signaling. It is express...
Shimokawa Mariko, Ohta Yuki, Nishikori Shingo, Matano Mami, Takano Ai, Fujii Masayuki, Date Shoichi, Sugimoto Shinya, Kanai Takanori, Sato Toshiro
Nature   545(7653) 187-192   May 2017
The cancer stem cell (CSC) theory highlights a self-renewing subpopulation of cancer cells that fuels tumour growth. The existence of human CSCs is mainly supported by xenotransplantation of prospectively isolated cells, but their clonal dynamics ...
Kon Shunsuke, Ishibashi Kojiro, Katoh Hiroto, Kitamoto Sho, Shirai Takanobu, Tanaka Shinya, Kajita Mihoko, Ishikawa Susumu, Yamauchi Hajime, Yako Yuta, Kamasaki Tomoko, Matsumoto Tomohiro, Watanabe Hirotaka, Egami Riku, Sasaki Ayana, Nishikawa Atsuko, Kameda Ikumi, Maruyama Takeshi, Narumi Rika, Morita Tomoko, Sasaki Yoshiteru, Enoki Ryosuke, Honma Sato, Imamura Hiromi, Oshima Masanobu, Soga Tomoyoshi, Miyazaki Jun Ichi, Duchen Michael R., Nam Jin Min, Onodera Yasuhito, Yoshioka Shingo, Kikuta Junichi, Ishii Masaru, Imajo Masamichi, Nishida Eisuke, Fujioka Yoichiro, Ohba Yusuke, Sato Toshiro, Fujita Yasuyuki
Nature Cell Biology   19(5) 530-541   May 2017
Recent studies have revealed that newly emerging transformed cells are often apically extruded from epithelial tissues. During this process, normal epithelial cells can recognize and actively eliminate transformed cells, a process called epithelia...
Sasaki Nobuo, Sato Toshiro, Clevers Hans
Biology and Engineering of Stem Cell Niches   111-125   Apr 2017
<p>Over the past 10years, insights into the biology of intestinal stem cells have rapidly increased. The adult intestinal epithelium represents one of the most suitable models to study tissue stem cells. It is the rapidly self-renewing tissue and ...
Ohashi Wakana, Kimura Shunsuke, Iwanaga Toshihiko, Furusawa Yukihiro, Irié Tarou, Izumi Hironori, Watanabe Takashi, Hijikata Atsushi, Hara Takafumi, Ohara Osamu, Koseki Haruhiko, Sato Toshiro, Robine Sylvie, Mori Hisashi, Hattori Yuichi, Watarai Hiroshi, Mishima Kenji, Ohno Hiroshi, Hase Koji, Fukada Toshiyuki
PLoS Genetics   12(10)    Oct 2016
Zinc transporters play a critical role in spatiotemporal regulation of zinc homeostasis. Although disruption of zinc homeostasis has been implicated in disorders such as intestinal inflammation and aberrant epithelial morphology, it is largely unk...

Conference Activities & Talks

 
腸管上皮におけるside population細胞の分離と機能解析
Satou Toshiaki, Matsuzaki Yumi, Kouike Hiroko, Ishii Yasumasa, Hibi Toshifumi, Okano Hideyuki
第2回日本再生医療学会   Mar 2003   
炎症性腸疾患における腸間膜リンパ節樹状細胞の解析
Sakuraba Atsushi, Satou Toshirou, Kishi Yuusuke, Hitotsumatsu Osamu, Yoshizawa Shigeo, Inoue Nagamu, Koganei Kazutaka, Fukushima Tsuneo, Ishii Hiromasa, Hibi Toshifumi
第44回日本消化器病学会   Oct 2002   
炎症性腸疾患における腸間膜リンパ節樹状細胞の解析
Sakuraba atsushi, Satou toshirou, Kishi yuusuke, Hitotsumatsu osamu, Yoshizawa shigeo, Inoue nagamu, Koganei kazutaka, Fukushima, Ishii masahiro, Hibi toshifumi
第44回日本消化器病学会   Oct 2002   
The Effects of Atorvastatin For Epithelial Cells and Ulcerative Colitis
Tamura Noriyasu, Sato Toshiro, Sakuraba Atsushi, Inoue Nagamu, Ishii Hiromasa, Hibi Toshifumi
International Congress of Mucosal Immunology   Jun 2002   
The Up-Regulation of Osteopntin and Its Pathogenetic Role in Crohn's Disease
Sato Toshiro, Inoue Nagamu, Sakuraba Atsushi, Ishii Hiromasa, Hibi Toshifumi
International Congress of Mucosal Immunology   Jun 2002   

Teaching Experience

 
 

Research Grants & Projects

 
Grant-in-Aid for Scientific Research (S)
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: May 2017 - Mar 2022    Investigator(s): Toshiro Sato
オルガノドライブラリーの構築による消化器疾患形質の統合的理解
Grant-in-Aid for Scientific Research (C)
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2020    Investigator(s): 股野麻未
消化器がん幹細胞を標的とした創薬スクリーニング
オルガノドライブラリーの構築による消化器疾患形質の統合的理解
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2018    Investigator(s): 佐藤 俊朗
Grant-in-Aid for Scientific Research (A)
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: Apr 2017 - May 2017    Investigator(s): Toshiro Sato
オルガノドライブラリーの構築による消化器疾患形質の統合的理解
Grant-in-Aid for Scientific Research (C)
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2019    Investigator(s): 股野麻未
遺伝子ネットワーク摂動による人工的な転移性大腸癌の作製
Grant-in-Aid for Scientific Research (A)
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2019    Investigator(s): 渡邉聡明
炎症粘膜を背景とした発癌メカニズムの統合的解析
Grant-in-Aid for Scientific Research (C)
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: Apr 2015 - Mar 2018    Investigator(s): 岩男泰
潰瘍性大腸炎関連大腸癌の新規分子マーカーの同定と治療法の開発
Understanding of invasion/metastasis mechanism in colorectal cancer using organoid technology
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2015 - Mar 2017    Investigator(s): 佐藤 俊朗
The pathological mechanism underlying cancer invasion and metastasis remains unknown. We generated 55 lines of human colon tumor organoids and comprehensively analyzed their molecular profiles, and thereby establishing functional assay platform fo...
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: Jul 2014 - Mar 2019    Investigator(s): Toshiro Sato
Establishing a new paradigm of the pathogenesis of diseases through the understanding of stem cell aging
老化ストレスシグナルによる腸管上皮幹細胞制御機構の解明
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Jul 2014 - Mar 2019    Investigator(s): 佐藤 俊朗
Establishment of Gene Engineered Organoids for Functional Analysis of Human Colorectal Driver Gene Mutations
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2014 - Mar 2017    Investigator(s): 佐藤 俊朗
Recent advance in sequence technology has enabled comprehensive analyses of genetic mutations in human colorectal cancer. In this study, we combined organoid culture technology and CRISPR-Cas9 technology to establish gene engineered organoids for ...