2019年1月
Low expression of a Ddm7/Ldm7-hybrid mutant (D/Ldm7) in the novel haplotype H-2nc identified in atopic dermatitis model NC/Nga mice
Genes and Immunity
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発表資料
回数 : 173
- ,
- ,
- ,
- 巻
- 20
- 号
- 1
- 開始ページ
- 74
- 終了ページ
- 81
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41435-017-0003-y
- 出版者・発行元
- Nature Publishing Group
Environmental factors and the major histocompatibility complex (MHC) are involved in the pathogenesis of atopic dermatitis (AD). However, MHC type (H2 haplotype) of AD model mice NC/Nga is poorly understood. Alloreactive CD8+ or CD4+ T cells in NC/Nga strongly responded to each antigen-presenting cells (A/J: H-2a, C57BL/6: H-2b, BALB/c: H-2d, or C3H/HeJ: H-2k), suggesting that NC/Nga has other H2 haplotype. Polymorphic microsatellite (CA)n repeats in TNF-α gene differ based on the H2 haplotype at present. NC/Nga’s (CA)n repeats (n = 19) were different from other examined strains, A/J (n = 14), BALB/c (n = 14), C3H/HeJ (n = 16), and C57BL/6 (n = 20). Using flow cytometry and genotyping, we demonstrated the NC/Nga H2 haplotype had a unique phenotype (Kd, I-Ak, and I-Ek) in which Dd and Ld lacked as protein despite sensitive mRNA detection. The loss of Dd and Ld was caused by forming a unique Ddm7/Ldm7-hybrid mutant (D/Ldm7). We propose to call this novel H2 haplotype the “H-2nc,” and provide the important information regarding the AD research using NC/Nga mice.
- リンク情報
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- DOI
- https://doi.org/10.1038/s41435-017-0003-y
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29282355
- URL
- https://www.nature.com/articles/s41435-017-0003-y.epdf?author_access_token=GtAfOIZQFd8oPgLk__oWKtRgN0jAjWel9jnR3ZoTv0NbLNskRR0-nKvod6Yjtn6sSUrPXLN66i1lvpGlnUNfK2DA9yk5ElZZCESmzacN7ZY6eW4fIqwXN7i7U9jUfKki6kwO0t_MHzuRWrBNkuI-ew%3D%3D
- ID情報
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- DOI : 10.1038/s41435-017-0003-y
- ISSN : 1476-5470
- ISSN : 1466-4879
- PubMed ID : 29282355
- SCOPUS ID : 85039153583