MISC

2009年10月

Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease

JOURNAL OF THE NEUROLOGICAL SCIENCES
  • Masaaki Waragai
  • Nobuyuki Okamura
  • Katsutoshi Furukawa
  • Manabu Tashiro
  • Shozo Furumoto
  • Yoshihito Funaki
  • Motohisa Kato
  • Ren Iwata
  • Kazuhiko Yanai
  • Yukitsuka Kudo
  • Hiroyuki Arai
  • 全て表示

285
1-2
開始ページ
100
終了ページ
108
記述言語
英語
掲載種別
DOI
10.1016/j.jns.2009.06.005
出版者・発行元
ELSEVIER SCIENCE BV

Two techniques employed for the early diagnosis of dementia are the imaging of amyloid-beta protein using positron emission tomography (PET) and voxel-based morphometry analysis of MRI (VBM-MRI). The purpose of this study was-to evaluate the clinical utility of amyloid PET and VBM-MRI for the early diagnosis and tracking of the severity of Alzheimer's disease (AD). The neuritic plaque burden and gray matter losses were evaluated using [C-11]BF-227-PET and VBM-MRI in 12 healthy controls, 13 subjects with mild cognitive impairment (MCI), including 6 who converted to AD and 7 who did not convert, and 15 AD patients. The AD patients and the MCI converters exhibited a neocortical retention of BF-227 and parahippocampal gray matter loss shown by VBM-MRI. The MCI converters were more clearly distinguished from the MCI non-converters in BF-227-PET than VBM-MRI. The combined sample of the MCI converters and AD patients showed a significant correlation of MMSE scores with the global gray matter loss, but not with the BF-227 retention. These findings suggest that amyloid PET using [C-11]BF-227 is better suited for the prediction of conversion from MCI to AD, while VBM-MRI appears to be better suited for tracking the severity of dementia. (C) 2009 Elsevier B.V. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.jns.2009.06.005
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000270476400017&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.jns.2009.06.005
  • ISSN : 0022-510X
  • eISSN : 1878-5883
  • Web of Science ID : WOS:000270476400017

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