MISC

本文へのリンクあり
2020年

Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases

Journal of Natural Medicines
  • Ikuro Abe

記述言語
掲載種別
書評論文,書評,文献紹介等
DOI
10.1007/s11418-020-01414-9

© 2020, The Japanese Society of Pharmacognosy. Recent research progress on the “second generation” type III polyketide synthases is summarized. This class of enzymes catalyzes unusual condensation chemistries of CoA thioesters to generate various core structures of medicinally important plant secondary metabolites, including the R1–C–R2 scaffold of alkyl quinolones, curcuminoids, as well as the 8-azabicyclo[3.2.1]octane ring of tropane alkaloids. The discovery of this fascinating enzyme superfamily provides excellent opportunities for the manipulation of the enzyme reactions to expand the supply of natural and unnatural molecules for future drug development.

リンク情報
DOI
https://doi.org/10.1007/s11418-020-01414-9
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085944884&origin=inward 本文へのリンクあり
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ID情報
  • DOI : 10.1007/s11418-020-01414-9
  • ISSN : 1340-3443
  • eISSN : 1861-0293
  • SCOPUS ID : 85085944884

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