1992年2月
MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY
TETRAHEDRON
- 巻
- 48
- 号
- 7
- 開始ページ
- 1193
- 終了ページ
- 1208
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0040-4020(01)90783-5
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
Comparison of the DNA cleavage activity of man-designed bleomycins demonstrates that bleomycins are small enzymes comprised of a catalytic site and a binding site. The linker moiety is shown to be significant for DNA binding, and inversion of its stereochemistry results in a dramatic decrease in the DNA-cleaving efficiency. One of the man-designed BLMs shows excellent cytotoxicity against L1210.
- リンク情報
- ID情報
-
- DOI : 10.1016/S0040-4020(01)90783-5
- ISSN : 0040-4020
- J-Global ID : 200902074837512153
- Web of Science ID : WOS:A1992HD49900003