2021年11月19日
Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation
Science Advances
- 巻
- 7
- 号
- 47
- 開始ページ
- eabj6895
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/sciadv.abj6895
- 出版者・発行元
- American Association for the Advancement of Science (AAAS)
Epithelial barriers that prevent dehydration and pathogen invasion are established by tight junctions (TJs), and their disruption leads to various inflammatory diseases and tissue destruction. However, a therapeutic strategy to overcome TJ disruption in diseases has not been established because of the lack of clinically applicable TJ-inducing molecules. Here, we found TJ-inducing peptides (JIPs) in mice and humans that corresponded to 35 to 42 residue peptides of the C terminus of alpha 1-antitrypsin (A1AT), an acute-phase anti-inflammatory protein. JIPs were inserted into the plasma membrane of epithelial cells, which promoted TJ formation by directly activating the heterotrimeric G protein G13. In a mouse intestinal epithelial injury model established by dextran sodium sulfate, mouse or human JIP administration restored TJ integrity and strongly prevented colitis. Our study has revealed TJ-inducing anti-inflammatory physiological peptides that play a critical role in tissue repair and proposes a previously unidentified therapeutic strategy for TJ-disrupted diseases.
- リンク情報
- ID情報
-
- DOI : 10.1126/sciadv.abj6895
- eISSN : 2375-2548
- PubMed ID : 34788088
- PubMed Central 記事ID : PMC8597994