2000年8月
Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
CELL
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- 巻
- 102
- 号
- 4
- 開始ページ
- 463
- 終了ページ
- 473
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0092-8674(00)00051-9
- 出版者・発行元
- CELL PRESS
It is well known that histone acetylases are important chromatin modifiers and that they play a central role in chromatin transcription. Here, we present evidence for novel roles of histone acetylases. The TIP60 histone acetylase purifies as a multimeric protein complex. Besides histone acetylase activity on chromatin, the TIP60 complex possesses ATPase, DNA helicase, and structural DNA binding activities. Ectopic expression of mutated TIP60 lacking histone acetylase activity results in cells with defective double-strand DNA break repair. Importantly, the resulting cells lose their apoptotic competence, suggesting a defect in the cells' ability to signal the existence of DNA damage to the apoptotic machinery. These results indicate that the histone acetylase TIP60-containing complex plays a role in DNA repair and apoptosis.
- リンク情報
- ID情報
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- DOI : 10.1016/S0092-8674(00)00051-9
- ISSN : 0092-8674
- PubMed ID : 10966108
- Web of Science ID : WOS:000088908000008