2007年
A sensitive gait parameter for quantification of arthritis in rats
Journal of Pharmacological Sciences
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- 巻
- 103
- 号
- 1
- 開始ページ
- 113
- 終了ページ
- 116
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1254/jphs.SC0060156
Quantification of arthritis is helpful for investigating pain mechanisms of arthritis and for developing new drugs. We assessed and identified a feasible parameter for quantification of rat arthritis using a novel gait analyzing system. Knee-joint injection with small doses of λ-carrageenan decreased swing time ratio (STR, swing time of the non-treated hindlimb/swing time of the λ-carrageenan-injected hindlimb) in a dose-dependent manner. Intraperitoneal treatment with indomethacin restored the decreased STR dose-dependently. The arthritis could not be accurately quantified by swing time and swelling, common indices of arthritis. These results show that STR is a sensitive, reliable parameter for quantification of arthritis. ©2007 The Japanese Pharmacological Society.
- リンク情報
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- DOI
- https://doi.org/10.1254/jphs.SC0060156
- CiNii Articles
- http://ci.nii.ac.jp/naid/10024312231
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/17202746
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33846649010&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=33846649010&origin=inward
- ID情報
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- DOI : 10.1254/jphs.SC0060156
- ISSN : 1347-8613
- ISSN : 1347-8648
- eISSN : 1347-8648
- CiNii Articles ID : 10024312231
- PubMed ID : 17202746
- SCOPUS ID : 33846649010