Papers

Peer-reviewed
Feb, 2016

Linoleic acid salt with ultrapure soft water as an antibacterial combination against dermato-pathogenic Staphylococcus spp.

JOURNAL OF APPLIED MICROBIOLOGY
  • H. Jang
  • ,
  • Y. Makita
  • ,
  • K. Jung
  • ,
  • S. Ishizaka
  • ,
  • K. Karasawa
  • ,
  • K. Oida
  • ,
  • M. Takai
  • ,
  • H. Matsuda
  • ,
  • A. Tanaka

Volume
120
Number
2
First page
280
Last page
288
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1111/jam.13012
Publisher
WILEY-BLACKWELL

AimsSkin colonization of Staphylococcus spp. critically affects the severity of dermatitis in humans and animals. We examined different types of fatty acid salts for their antibacterial activity against Staphylococcus spp. when used in ultrapure soft water (UPSW). We also evaluated their therapeutic effect on a spontaneous canine model of dermatitis.
Methods and ResultsUPSW, in which Ca++ and Mg++ were replaced with Na+, was generated using a water softener with cation-exchange resin. Staphylococcus aureus (Staph.aureus), Staphylococcus intermedius (Staph. intermedius), and Staphylococcus pseudintermedius (Staph.pseudintermedius) were incubated with various fatty acid salts in distilled water (DW) or UPSW and the number of bacteria was counted. Among the fatty acids, oleic acid salt and linoleic acid (LA) salt reduced the number of these bacteria. Also, UPSW enhanced the antibacterial effect of LA on Staph. spp. In spontaneously developed itchy dermatitis in companion dogs, shampoo treatment with liquid soap containing 10% LA in UPSW improved skin conditions.
ConclusionsLA salt showed antibacterial activity against Staph. spp. Treatment with soap containing LA with UPSW reduced clinical conditions in dogs with dermatitis.
Significance and Impact of the StudyBecause colonization of Staph. spp. on the skin exacerbates dermatitis, the use of LA-containing soap in UPSW may reduce unpleasant clinical symptoms of the skin.

Link information
DOI
https://doi.org/10.1111/jam.13012
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000368793500003&DestApp=WOS_CPL
ID information
  • DOI : 10.1111/jam.13012
  • ISSN : 1364-5072
  • eISSN : 1365-2672
  • Web of Science ID : WOS:000368793500003

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