KUBOTA Takaaki

J-GLOBAL         Last updated: Nov 10, 2018 at 14:48
 
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Name
KUBOTA Takaaki
Nickname
takaaki_kubota
E-mail
kubotaac.shoyaku.ac.jp
URL
http://www.pharm.hokudai.ac.jp/tennen/index.html
Affiliation
Showa Pharmaceutical University
Section
Faculty of Pharmaceutical Sciences
Job title
Associate Professor
Degree
2002, Ph. D. (Pharmaceutical Sciences), Hokkaido University(Hokkaido University)
Research funding number
60399954
ORCID ID
0000-0002-3553-5844

Research Areas

 
 

Academic & Professional Experience

 
Apr 2015
 - 
Today
Professor, Showa Pharmaceutical University
 
Apr 2010
 - 
Mar 2015
Associate Professor, Hokkaido University
 
2008
 - 
2015
Associate Professor, Hokkaido University
 
Feb 2009
 - 
Mar 2010
Associate Professor, Hokkaido University
 
Sep 2008
 - 
Jan 2009
Associate Professor, Hokkaido University
 
Apr 2006
 - 
Aug 2008
Lecturer, Hokkaido University
 
2005
 - 
2008
Lecturer, Hokkaido University
 
Apr 2005
 - 
Mar 2006
Lecturer, Hokkaido University
 
Feb 2005
 - 
Mar 2005
Research Associate, Hokkaido University
 
Apr 2003
 - 
Jan 2005
Research Associate, Department of Chemistry, University of Washington
 
Apr 2002
 - 
Mar 2003
Postdoctoral Fellowships of Japan Society for the Promotion of Science, Japan Society for the Promotion of Science
 
Apr 2001
 - 
Mar 2002
Postdoctoral Fellowships of Japan Society for the Promotion of Science, Japan Society for the Promotion of Science
 

Education

 
 
 - 
2002
Graduate School, Division of Pharmaceutical Sciences, Hokkaido University
 
 
 - 
1999
Graduate School, Division of Pharmaceutical Sciences, Hokkaido University
 
 
 - 
1996
Faculty of Pharmaceutical Science, Tokyo University of Science
 

Published Papers

 
Kubota T, Ishiguro Y, Takahashi-Nakaguchi A, Fromont J, Gonoi T, Kobayashi J
Bioorganic & medicinal chemistry letters      Nov 2012   [Refereed]
Tanaka N, Suto S, Ishiyama H, Kubota T, Yamano A, Shiro M, Fromont J, Kobayashi J
Organic letters   14(13) 3498-3501   Jul 2012   [Refereed]
Kubota T, Watase S, Mukai H, Fromont J, Kobayashi J
Chemical & pharmaceutical bulletin   60(12) 1599-1601   2012   [Refereed]
Suzuki T, Kubota T, Kobayashi J
Bioorganic & medicinal chemistry letters   21(14) 4220-4223   Jul 2011   [Refereed]
Takahashi Y, Kubota T, Shibazaki A, Gonoi T, Fromont J, Kobayashi J
Organic letters   13(12) 3016-3019   Jun 2011   [Refereed]
Takahashi Y, Iinuma Y, Kubota T, Tsuda M, Sekiguchi M, Mikami Y, Fromont J, Kobayashi J
Organic letters   13(4) 628-631   Feb 2011   [Refereed]
Kura K, Kubota T, Fromont J, Kobayashi J
Bioorganic & medicinal chemistry letters   21(1) 267-270   Jan 2011   [Refereed]
Ishiuchi K, Kubota T, Ishiyama H, Hayashi S, Shibata T, Mori K, Obara Y, Nakahata N, Kobayashi J
Bioorganic & medicinal chemistry   19(2) 749-753   Jan 2011   [Refereed]
Kon Y, Kubota T, Shibazaki A, Gonoi T, Kobayashi J
Bioorganic & medicinal chemistry letters   20(15) 4569-4572   Aug 2010   [Refereed]
Takahashi Y, Ishiyama H, Kubota T, Kobayashi J
Bioorganic & medicinal chemistry letters   20(14) 4100-4103   Jul 2010   [Refereed]
Takahashi Y, Ushio M, Kubota T, Yamamoto S, Fromont J, Kobayashi J
Journal of natural products   73(3) 467-471   Mar 2010   [Refereed]
Tanaka N, Kubota T, Kashiwada Y, Takaishi Y, Kobayashi J
Chemical & pharmaceutical bulletin   57(10) 1171-1173   Oct 2009   [Refereed]
Ishiuchi K, Kodama S, Kubota T, Hayashi S, Shibata T, Kobayashi J
Chemical & pharmaceutical bulletin   57(8) 877-881   Aug 2009   [Refereed]
Kubota T, Yahata H, Yamamoto S, Hayashi S, Shibata T, Kobayashi J
Bioorganic & medicinal chemistry letters   19(13) 3577-3580   Jul 2009   [Refereed]
Kobayashi J, Kubota T
Natural product reports   26(7) 936-962   Jul 2009   [Refereed]
Kubota T, Suzuki T, Ishiuchi K, Kuhara T, Kobayashi J
Chemical & pharmaceutical bulletin   57(5) 504-507   May 2009   [Refereed]
Araki A, Kubota T, Aoyama K, Mikami Y, Fromont J, Kobayashi J
Organic letters   11(8) 1785-1788   Apr 2009   [Refereed]
Takahashi Y, Kubota T, Kobayashi J
Bioorganic & medicinal chemistry   17 2185-2188   Mar 2009   [Refereed]
Mukai H, Kubota T, Aoyama K, Mikami Y, Fromont J, Kobayashi J
Bioorganic & medicinal chemistry letters   19(5) 1337-1339   Mar 2009   [Refereed]
Yasuda T, Araki A, Kubota T, Ito J, Mikami Y, Fromont J, Kobayashi J
Journal of natural products   72(3) 488-491   Mar 2009   [Refereed]
Takahashi Y, Kubota T, Fromont J, Kobayashi J
Organic letters   11(1) 21-24   Jan 2009   [Refereed]
Yahata H, Kubota T, Kobayashi J
Journal of natural products   72(1) 148-151   Jan 2009   [Refereed]
Fürstner A, Flügge S, Larionov O, Takahashi Y, Kubota T, Kobayashi J
Chemistry (Weinheim an der Bergstrasse, Germany)   15(16) 4011-4029   2009   [Refereed]
Takahashi Y, Kubota T, Fukushi E, Kawabata J, Kobayashi J
Organic letters   10(17) 3709-3711   Sep 2008   [Refereed]
Takahashi Y, Kubota T, Ito J, Mikami Y, Fromont J, Kobayashi J
Bioorganic & medicinal chemistry   16 7561-7564   Aug 2008   [Refereed]
Araki A, Kubota T, Tsuda M, Mikami Y, Fromont J, Kobayashi J
Organic letters   10(11) 2099-2102   Jun 2008   [Refereed]
Tanaka N, Kubota T, Ishiyama H, Araki A, Kashiwada Y, Takaishi Y, Mikami Y, Kobayashi J
Bioorganic & medicinal chemistry   16 5619-5623   May 2008   [Refereed]
Shen YC, Cheng YB, Kobayashi J, Kubota T, Takahashi Y, Mikami Y, Ito J, Lin YS
Journal of natural products   70(12) 1961-1965   Dec 2007   [Refereed]
Takahashi Y, Yamada M, Kubota T, Fromont J, Kobayashi J
Chemical & pharmaceutical bulletin   55(12) 1731-1733   Dec 2007   [Refereed]
Araki A, Tsuda M, Kubota T, Mikami Y, Fromont J, Kobayashi J
Organic letters   9(12) 2369-2371   Jun 2007   [Refereed]
Takahashi Y, Kubota T, Kobayashi J
The Journal of antibiotics   60 376-379   Jun 2007   [Refereed]
Kobayashi J, Kubota T
Journal of natural products   70(3) 451-460   Mar 2007   [Refereed]
Saito S, Kubota T, Fukushi E, Kawabata J, Zhang H, Kobayashi J
Organic letters   9(7) 1207-1209   Mar 2007   [Refereed]
Ishiuchi K, Kubota T, Mikami Y, Obara Y, Nakahata N, Kobayashi J
Bioorganic & medicinal chemistry   15 413-417   Jan 2007   [Refereed]
Kariya Y, Kubota T, Fromont J, Kobayashi J
Bioorganic & medicinal chemistry   14 8415-8419   Dec 2006   [Refereed]
Usui T, Nagumo Y, Watanabe A, Kubota T, Komatsu K, Kobayashi J, Osada H
Chemistry & biology   13 1153-1160   Nov 2006   [Refereed]
Kagata T, Saito S, Shigemori H, Ohsaki A, Ishiyama H, Kubota T, Kobayashi J
Journal of natural products   69(10) 1517-1521   Oct 2006   [Refereed]
Ishiuchi K, Kubota T, Hoshino T, Obara Y, Nakahata N, Kobayashi J
Bioorganic & medicinal chemistry   14 5995-6000   Sep 2006   [Refereed]
Kubota T, Brünjes M, Frenzel T, Xu J, Kirschning A, Floss HG
Chembiochem : a European journal of chemical biology   7 1221-1225   Aug 2006   [Refereed]
Kubota T, Endo T, Takahashi Y, Tsuda M, Kobayashi J
The Journal of antibiotics   59 512-516   Aug 2006   [Refereed]
Kubota T, Iinuma Y, Kobayashi J
Biological & pharmaceutical bulletin   29(7) 1314-1318   Jul 2006   [Refereed]
Kazami S, Muroi M, Kawatani M, Kubota T, Usui T, Kobayashi J, Osada H
Bioscience, biotechnology, and biochemistry   70(6) 1364-1370   Jun 2006   [Refereed]
Kubota T, Tsuda M, Kobayashi J
The Journal of organic chemistry   67(5) 1651-1656   Mar 2002   [Refereed]
Kobayashi J, Kubota T, Takahashi M, Ishibashi M, Tsuda M, Naoki H
The Journal of organic chemistry   64(5) 1478-1482   Mar 1999   [Refereed]

Misc

 
久保田高明, 鈴木哲平, 小林淳一
日本薬学会年会要旨集   132nd(2) 194   Mar 2012
久保田高明
生物工学会誌   89(10) 617   Oct 2011
久保田高明, 石黒悠一朗, 城始勇, 小林淳一
日本薬学会年会要旨集   131st(2) 230   Mar 2011
高橋洋平, 久保田高明, 小林淳一
天然有機化合物討論会講演要旨集   52nd 661-666   Sep 2010
田中直伸, 久保田高明, 柏田良樹, 高石喜久, 小林淳一
日本薬学会年会要旨集   130th(2) 233   Mar 2010
久保田高明, 石黒悠一朗, 山本淳, 小林淳一
日本薬学会年会要旨集   130th(2) 221   Mar 2010
石内勘一郎, 久保田高明, 林茂樹, 柴田敏郎, 小林淳一
日本薬学会年会要旨集   130th(2) 239   Mar 2010
石内勘一郎, 児玉志保美, 久保田高明, 小林淳一, 林茂樹, 柴田敏郎
日本生薬学会年会講演要旨集   56th 141   Sep 2009
田中直伸, 格口ゆか, 石山玄明, 久保田高明, 小林淳一
日本生薬学会年会講演要旨集   56th 256   Sep 2009
高橋洋平, 山田美香, 久保田高明, 石山亜紀, 乙黒一彦, 山田陽城, 大村智, 小林淳一
天然有機化合物討論会講演要旨集   51st 581-586   Sep 2009
石内勘一郎, 久保田高明, 林茂樹, 柴田敏郎, 小林淳一
天然有機化合物討論会講演要旨集   51st 19-24   Sep 2009
萩行正博, 石山玄明, 高橋洋平, 久保田高明, 小林淳一
次世代を担う有機化学シンポジウム講演要旨集   7th 38-39   May 2009
久保田高明, 向井裕也, 小林淳一
日本薬学会年会要旨集   129th(2) 179   Mar 2009
田中直伸, 大豆村拓自, 久保田高明, 今林潔, 柏田良樹, 高石喜久, 小林淳一
日本薬学会年会要旨集   129th(2) 172   Mar 2009
萩行正博, 石山玄明, 高橋洋平, 久保田高明, 小林淳一
日本薬学会年会要旨集   129th(2) 95   Mar 2009
石内勘一郎, 久保田高明, 柴田敏郎, 小林淳一
日本薬学会年会要旨集   129th(2) 97   Mar 2009
石山玄明, 格口ゆか, 高橋洋平, 久保田高明, 小林淳一
日本薬学会年会要旨集   129th(2) 179   Mar 2009
荒木敦, 久保田高明, 三上襄, 小林淳一
天然薬物の開発と応用シンポジウム講演要旨集   17th 79-80   Nov 2008
久保田高明, 渡辺梢, 小林淳一, 新里孝和, 伊藤淳二, 三上襄
日本生薬学会年会講演要旨集   55th 219   Sep 2008
高橋洋平, 久保田高明, 三上襄, 小林淳一
天然有機化合物討論会講演要旨集   50th 59-64   Sep 2008
田中直伸, 久保田高明, 石山玄明, 小林淳一, 柏田良樹, 高石喜久, 伊藤淳二, 三上襄, 城始勇
日本生薬学会年会講演要旨集   55th 188   Sep 2008
荒木敦, 安田鉄郎, 久保田高明, 三上襄, 小林淳一
天然有機化合物討論会講演要旨集   50th 361-366   Sep 2008
Araki Atsushi, Yasuda Tetsuro, Kubota Takaaki, Mikami Yuzuru, Kobayashi Jun'ichi
0(50) 361-366   Sep 2008
Bromopyrrole alkaloids are known to be one of the most common metabolites contained in marine sponges. During our search for bioactive substances from marine organisms, we have isolated bromopyrrole alkaloids with unique cyclic skeletons from spon...
Takahashi Yohei, Kubota Takaaki, Mikami Yuzuru, Kobayashi Jun'ichi
0(50) 59-64   Sep 2008
Sesquiterpenoid quinines and hydroquinones are representative marine natural products with unique structures and interesting biological activities. In our continuous search for bioactive compounds having unique structures from Okinawan marine spon...
風見紗弥香, 風見紗弥香, 臼井健郎, 臼井健郎, 久保田高明, 小林淳一, 長田裕之, 長田裕之
日本農芸化学会大会講演要旨集   2008 9   Mar 2008
田中直伸, 久保田高明, 荒木敦, 柏田良樹, 高石喜久, 三上襄, 小林淳一
日本薬学会年会要旨集   128th(2) 11   Mar 2008
八幡弘子, 齊藤静夏, 久保田高明, 小原祐太郎, 中畑則道, 小林淳一
日本薬学会年会要旨集   128th(2) 12   Mar 2008
久保田高明, 西貴美, 佐々木琢磨, 小林淳一
日本薬学会年会要旨集   128th(2) 12   Mar 2008
山田美香, 高橋洋平, 久保田高明, 小林淳一
日本薬学会年会要旨集   128th(2) 11   Mar 2008
久保田高明, 八幡弘子, 石内勘一郎, 小林淳一
日本生薬学会年会講演要旨集   54th 226   Sep 2007
安田鉄郎, 荒木敦, 津田正史, 久保田高明, 福士江里, 川端潤, 小林淳一
天然有機化合物討論会講演要旨集   49th 1-6   Aug 2007
齊藤静夏, 久保田高明, 福士江里, 川端潤, ZHANG Huiping, 小林淳一
天然有機化合物討論会講演要旨集   49th 271-276   Aug 2007
Yasuda Tetsuro, Araki Atsushi, Tsuda Masashi, Kubota Takaaki, Fukushi Eri, Kawabata Jun, Kobayashi Jun'ichi
0(49) 1-6   Aug 2007
Diffusion-ordered NMR spectroscopy (DOSY) is a versatile and powerful NMR technique and a noninvasive analytical method for mixture analysis that does not require prior physical separation of the analysis. In our search for new metabolites from na...
Saito Shizuka, Kubota Takaaki, Fukushi Eri, Kawabata Jun, Zhang Huiping, Kobayashi Jun'ichi
0(49) 271-276   Aug 2007
Daphniphyllum alkaloids are a structually diverse group of natural products with unique fused-heterocyclic skeletons, which are elaborated by trees of the genus Daphniphyllum (Daphniphyllaceae). These unusual ring systems have been challenging tar...
高橋洋平, 久保田高明, 小林淳一
次世代を担う有機化学シンポジウム講演要旨集   5th 6-7   May 2007
臼井健郎, 臼井健郎, 南雲陽子, 南雲陽子, 渡邉愛, 久保田高明, 小林淳一, 長田裕之
日本農芸化学会大会講演要旨集   2007 98   Mar 2007
MATSUNO YOSUKE, OKAMOTO MARIKO, ZAIMA KAZUMASA, KUBOTA TAKAAKI, KOBAYASHI JUN'ICHI, SHINZATO TAKAKAZU, MORITA HIROSHI
薬学雑誌   126(Suppl.5) 100-103   Nov 2006
KUBOTA TAKAAKI, NOZAWA KOHEI, TSUDA MASASHI, ISHIYAMA HARUAKI, KAZAMI SAYAKA, USUI TAKEO, OSADA HIROYUKI, KOBAYASHI JUN'ICHI
薬学雑誌   126(Suppl.5) 222-225   Nov 2006
石内勘一郎, 久保田高明, 森田博史, 星野智洋, 小原祐太郎, 中畑則道, 小林淳一
天然有機化合物討論会講演要旨集   48th 493-498   Sep 2006
Ishiuchi Kan'ichiro, Kubota Takaaki, Morita Hiroshi, Hoshino Tomohiro, Obara Yutaro, Nakahata Norimichi, Kobayashi Jun'ichi
0(48) 493-498   Sep 2006
Club moss (Lycopodiaceae) is known to be a rich source of Lycopodium alkaloids posessing unique heterocyclic ring systems such as C_<16>N, C_<16>N_2, and C_<27>N_3, which have attracted great interest from biogenetic, synthetic, and biological poi...
石内勘一郎, 久保田高明, 小林淳一, 森田博史, 星野智洋, 小原祐太郎, 中畑則道
日本生薬学会年会講演要旨集   53rd 157   Sep 2006
松野陽介, 松野陽介, 久保田高明, 森田博史, 新里孝和, 関口光広, 小林淳一
日本生薬学会年会講演要旨集   53rd 152   Sep 2006
小林淳一, 久保田高明
日本癌学会学術総会記事   65th 466-467   Aug 2006
石内勘一郎, 久保田高明, 小林淳一, 森田博史
万有生命科学振興国際交流財団札幌シンポジウム   18th 42   Jul 2006
KOBAYASHI JUN'ICHI, KUBOTA TAKAAKI
化学   61(6) 68-69   Jun 2006
久保田高明, 仮屋佑子, 小林淳一
日本薬学会年会要旨集   126th(4) 86   Mar 2006
風見紗弥香, 臼井健郎, 室井誠, 久保田高明, 小林淳一, 長田裕之
日本農芸化学会大会講演要旨集   2006 11   Mar 2006
久保田高明, 佐久間祐介, 新保和高, 津田正史, 魚住泰広, 小林淳一
天然有機化合物討論会講演要旨集   47th 151-156   Sep 2005
Kubota Takaaki, Sakuma Yusuke, Shimbo Kazutaka, Tsuda Masashi, Uozumi Yasuhiro, Kobayashi Jun'ichi
0(47) 151-156   Sep 2005
Amphezonol A (1), a novel polyhydroxyl compound, was isolated from a marine dinoflagellate Amphidinium sp. (Y-72), and the structure was elucidated on the basis of 2D NMR data including HSQC-TOCSY and INADEQUATE spectra (920MHz) using the ^<13>C-e...
久保田高明, 佐久間裕介, 新保和高, 津田正史, 小林淳一
マリンバイオテクノロジー学会大会講演要旨集   8th 109   May 2005
KUBOTA TAKAAKI, TSUDA MASASHI, KOBAYASHI JUN'ICHI
日本化学会講演予稿集   81st(2) 707   Mar 2002
TSUDA MASASHI, KUBOTA TAKAAKI, SHIMBO KAZUTAKA, HORIGUCHI TAKEO, KATSUMATA KAZUHITO, KOBAYASHI JUN'ICHI
日本化学会講演予稿集   80th 3   Sep 2001
KUBOTA TAKAAKI, TSUDA MASASHI, ENDO TETSUYA, SHIRO MOTOO, KOBAYASHI JUN'ICHI
天然有機化合物討論会講演要旨集   43rd 97-102   Sep 2001
Kubota Takaaki, Tsuda Masashi, Endo Tetsuya, Shiro Motoo, Kobayashi Jun'ichi
0(43) 97-102   Sep 2001
Amphidinolide C (1) is a unique 25-membered macrolide isolated from a marine dinoflagellate Amphidinium sp. (strain Y-5). The gross structure of 1 has been elucidated by 2D-NMR data, whereas the stereochemistry remains undefined. During our search...
久保田高明, 津田正史, 平野敬子, 渡部賢二, 小林淳一
日本薬学会年会要旨集   121st(2) 119   Mar 2001
SHIMBO KAZUTAKA, KUBOTA TAKAAKI, TSUDA MASASHI, KOBAYASHI JUN'ICHI
日本化学会講演予稿集   78th(2) 849   Mar 2000
KUBOTA TAKAAKI, TSUDA MASASHI, KOBAYASHI JUN'ICHI
日本化学会講演予稿集   78th(2) 884   Mar 2000
KUBOTA TAKAAKI, TSUDA MASAFUMI, TAKAHASHI MIHO, ISHIBASHI MASAMI, KOBAYASHI JUN'ICHI, NAOKI HIDEO
天然有機化合物討論会講演要旨集   41st 595-600   Sep 1999
Kubota Takaaki, Tsuda Masashi, Takahashi Miho, Ishibashi Masami, Kobayashi Jun'ichi, Naoki Hideo
0(41) 595-600   Sep 1999
Marine dinoflagellates of the genus Amphidinium have been recognized as a rich source of novel bioactive substances with unique structures. We previously isolated a series of cytotoxic macrolides, designated amphidinolides, possessing unique struc...
Kubota Takaaki, Tsuda Masashi, Doi Yukiko, Takahashi Ayako, Nakamichi Hiroko, Ishibashi Masami, Fukushi Eri, Kawabata Jun, Kobayashi Jun'ichi
0(40) 473-478   Aug 1998
During our continuing search for structurally unique secondary metabolites from marine dinoflagellates, we previously isolated a series of cytotoxic macrolides, amphidinolides, from dinoflagellates Amphidinium sp. Recently we investigated another ...
KUBOTA TAKAAKI, TSUDA MASASHI, DOI YUKIKO, TAKAHASHI AYAKO, NAKAMICHI HIROKO, ISHIBASHI MASAMI, FUKUSHI ERI, KAWABATA JUN, KOBAYASHI JUN'ICHI
天然有機化合物討論会講演要旨集   40th 473-478   Aug 1998
KUBOTA TAKAAKI, TSUDA MASAFUMI, DOI YUKIKO, NAKAMICHI HIROKO, ISHIBASHI MASAMI, KOBAYASHI JUN'ICHI
日本薬学会年会要旨集   118th(2) 108   Mar 1998

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2004 - 2005    Investigator(s): Jun'ichi KOBAYASHI
1)Eight stilbenoids, 1-(p-hydroxybenzyl)-4,8-dimethoxyphenanthrene-2,7-diol (1), 2,7-dihydroxy-1,3-bis(p-hydroxybenzyl)-4-methoxy-9,10-dihydrophenanthrene (2), 4,7-dihydroxy-1-(p-hydroxyberzyl)-2-methoxy-9,10-dihydrophenanthrene (3), 3,3'-dihydrox...
Search for bioactive natural products and its biosynthesis
Project Year: 1995   

Patents

 
特開2007-104 (P2007-104A)