Chikara Kaito

J-GLOBAL         Last updated: Aug 22, 2019 at 12:40
 
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Name
Chikara Kaito
Affiliation
Okayama University
Section
Graduate School of Pharmaceutical Sciences
Job title
Associate Professor
Degree
Ph.D.(The University of Tokyo)

Research Areas

 
 

Academic & Professional Experience

 
Jul 2010
   
 
- Associate Professor
 
Mar 2008
   
 
- Lecturer (Senior Assistant Professor)
 
Jul 2005
   
 
- Assistant Professor
 
Apr 2005
   
 
- Postdoctoral fellow
 

Education

 
 
 - 
2005
Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
 
 
 - 
2000
Zoological Science, Faculty of Science, The University of Tokyo
 

Published Papers

 
Ryuno H, Nigo F, Naguro I, Sekimizu K, Kaito C
PLOS ONE   14(5) e0217517   May 2019   [Refereed]
Mitsutomi S, Sekimizu K, Kaito C
Drug Discoveries and Therapeutics   11(5) 267-275   Oct 2017   [Refereed]
Kochi Y, Matsumoto Y, Sekimizu K, Kaito C
Drug Discoveries and Therapeutics   11(5) 259-266   Oct 2017   [Refereed]
Kizaki H, Omae Y, Tabuchi F, Saito Y, Sekimizu K, Kaito C
PLOS ONE   11(10) e0164523   Oct 2016   [Refereed]
Imae K, Saito Y, Kizaki H, Ryuno H, Mao H, Miyashita A, Suzuki Y, Sekimizu K, Kaito C
The Journal of Biological Chemistry   291(36) 18608-19: Paper of the Week   Sep 2016   [Refereed]
Kochi Y, Miyashita A, Tsuchiya K, Mitsuyama M, Sekimizu K, Kaito C
FEMS Microbiology Letters   363(15) fnw163   Aug 2016   [Refereed]
Miyashita A, Kizaki H, Sekimizu K, Kaito C
Biology Open   5(6) 770-6   Jun 2016   [Refereed]
Suzuki T, Yamamoto T, Kaito C, Miyamoto H, Ohashi Y
Microbial Drug Resistance   22(7) 589-597   Oct 2016   [Refereed]
Kaito C
Drug Discoveries and Therapeutics   10(1) 30-33   Feb 2016   [Refereed]
Yoshikai H, Kizaki H, Saito Y, Omae Y, Sekimizu K, Kaito C
The Journal of Infectious Diseases   213(2) 295-304   Jan 2016   [Refereed]
Miyashita A, Kizaki H, Sekimizu K, Kaito C
PLOS ONE   11(1) e0146999   Jan 2016   [Refereed]
Kyuma T, Kizaki H, Ryuno H, Sekimizu K, Kaito C
Biochimie   119 166-174   Dec 2015   [Refereed]
Ishii K, Tabuchi F, Matsuo M, Tatsuno K, Sato T, Okazaki M, Hamamoto H, Matsumoto Y, Kaito C, Aoyagi T, Hiramatsu K, Kaku M, Moriya K, Sekimizu K
Scientific Reports   5 17092   Nov 2015   [Refereed]
Kyuma T, Kimura S, Hanada Y, Suzuki T, Sekimizu K, Kaito C
The FEBS journal   282(13) 2570-2584   Jul 2015   [Refereed]
Miyashita A, Takahashi S, Ishii K, Sekimizu K, Kaito C
PLOS ONE   10(6) e0130486   Jun 2015   [Refereed]
Nwibo DD, Hamamoto H, Matsumoto Y, Kaito C, Sekimizu K
Drug Discoveries and Therapeutics   9(2) 133-135   Apr 2015   [Refereed]
Miyashita A, Hirai Y, Sekimizu K, Kaito C
Drug Discoveries and Therapeutics   9(1) 33-37   Feb 2015   [Refereed]
Aoyagi T, Kaito C, Sekimizu K, Omae Y, Saito Y, Mao H, Inomata S, Hatta M, Endo S, Gu Y, Tokuda K, Yano H, Kitagawa M, Kaku M.
Clinical Microbiology and Infection   20(9) 912-919   Sep 2014   [Refereed]
BACKGROUND:
Over-expression of alpha-phenol-soluble modulins (PSMs) result in high virulence of community-associated methicillin-resistant Staphylococcus aureus (MRSA). The psm-mec gene, located in the mobile genetic element SCCmec-II, suppresses ...
Ikuo M, Nagano G, Saito Y, Mao H, Sekimizu K, Kaito C
PLOS ONE   9(6) e100260   Jun 2014   [Refereed]
Miyashita A, Kizaki H, Kawasaki K, Sekimizu K, Kaito C
The Journal of Biological Chemistry   289(20) 14412-14421   May 2014   [Refereed]
A heightened immune response, in which immune responses are primed by repeated exposure to a pathogen, is an important characteristic of vertebrate adaptive immunity. In the present study, we examined whether invertebrate animals also exhibit a pr...
Omae Y, Sekimizu K, Kaito C
PLOS ONE   9(5) e97670   May 2014   [Refereed]
Kaito C, Sekimizu K
Bio-protocol   4(6) e1071   Mar 2014   [Refereed]
Numata S, Nagata M, Mao H, Sekimizu K, Kaito C
The Journal of Biological Chemistry   289(12) 8420-8431   Mar 2014   [Refereed]
We previously identified CvfA (SA1129) as a Staphylococcus aureus virulence factor using a silkworm infection model. S. aureus cvfA-deleted mutants exhibit decreased expression of the agr locus encoding a positive regulator of hemolysin genes and ...
Omae Y, Hanada Y, Sekimizu K, Kaito C
The Journal of Biological Chemistry   288(35) 25542-50   Sep 2013   [Refereed]
We previously reported that a silkworm hemolymph protein, apolipophorin (ApoLp), binds to the cell surface of Staphylococcus aureus and inhibits expression of the saePQRS operon encoding a two-component system, SaeRS, and hemolysin genes. In this ...
Kaito C, Saito Y, Ikuo M, Omae Y, Mao H, Nagano G, Fujiyuki T, Numata S, Han X, Obata K, Hasegawa S, Yamaguchi H, Inokuchi K, Ito T, Hiramatsu K, Sekimizu K
PLOS Pathogens   9(4) e1003269   Apr 2013   [Refereed]
Miyashita A, Iyoda S, Ishii K, Hamamoto H, Sekimizu K, Kaito C
FEMS Microbiology Letters   333(1) 59-68   Aug 2012   [Refereed]
Omae Y, Sekimizu K, Kaito C
The Journal of Biological Chemistry   287(19) 15570-15579   May 2012   [Refereed]
Miyazaki S, Matsumoto Y, Sekimizu K, Kaito C
FEMS Microbiology Letters   326(2) 116-124   Jan 2012   [Refereed]
Kaito C, Yoshikai H, Sekimizu K
Invertebrate Survival Journal   9 163-168   2012   [Refereed]
Hanada Y, Sekimizu K, Kaito C
The Journal of Biological Chemistry   286(45) 39360-39369   Nov 2011   [Refereed]
Ueda T, Kaito C, Omae Y, Sekimizu K
Microbial Pathogenesis   51(3) 178-185   Sep 2011   [Refereed]
Kaito C, Hirano T, Omae Y, Sekimizu K
Microbial pathogenesis   51(3) 142-148   Sep 2011   [Refereed]
Kaito C, Usui K, Kyuma T, Sekimizu K
Drug Discoveries and Therapeutics   5(2) 66-70   2011   [Refereed]
Ikuo M, Kaito C, Sekimizu K
Microbial pathogenesis   49(1-2) 1-7   Jul 2010   [Refereed]
Usui K, Miyazaki S, Kaito C, Sekimizu K
Microbial pathogenesis   46(2) 59-62   Feb 2009   [Refereed]
Kaito C, Omae Y, Matsumoto Y, Nagata M, Yamaguchi H, Aoto T, Ito T, Hiramatsu K, Sekimizu K.
PLOS ONE   3(12) e3921   Dec 2008   [Refereed]
Shiokawa K, Aso M, Kondo T, Uchiyama H, Kuroyanagi S, Takai J, Takahashi S, Kajitani M, Kaito C, Sekimizu K, Takayama E, Igarashi K, Hara H
Gene Regulation and Systems Biology   29(2) 213-231   May 2008   [Refereed]
Nagata M, Kaito C, Sekimizu K.
The Journal of Biological Chemistry   283(4) 2176-2184   Jan 2008   [Refereed]
Matsumoto Y, Kaito C, Morishita D, Kurokawa K, Sekimizu K.
Infection and Immunity   75(4) 1964-1972   Apr 2007   [Refereed]
Kaito C, Sekimizu K.
Journal of Bacteriology   189(6) 2553-2557   Mar 2007   [Refereed]
Kaito C, Sekimizu K.
Drug Discoveries and Therapeutics   1(2) 89-93   2007   [Refereed]
Kurokawa K, Kaito C, Sekimizu K.
Methods in Enzymology   422 233-44   2007   [Refereed]
Kaito C, Morishita D, Matsumoto Y, Kurokawa K, Sekimizu K.
Molecular Microbiology   62(6) 1601-1617   Dec 2006   [Refereed]
Hossain MS, Hamamoto H, Matsumoto Y, Razanajatovo IM, Larranaga J, Kaito C, Kasuga H, Sekimizu K
The Journal of Biochemistry   140(3) 439-444   Sep 2006   [Refereed]
Eguchi Y, Ueno S, Kaito C, Sekimizu K, Shiokawa K
Bioelectromagnetics   27(4) 307-13   May 2006   [Refereed]
Shiokawa K, Takayama E, Higo T, Kuroyanagi S, Kaito C, Hara H, Kajitani M, Sekimizu K, Tadakuma T, Miura K, Igarashi K, Yaoita Y
Biochemical and Biophysical Research Communications   336(2) 682-691   Oct 2005   [Refereed]
Kaito C, Kurokawa K, Matsumoto Y, Terao Y, Kawabata S, Hamada S, Sekimizu K.
Molecular Microbiology   56(4) 934-944   May 2005   [Refereed]
Kawamura N, Kurokawa K, Ito T, Hamamoto H, Koyama H, Kaito C, Sekimizu K
Genes to Cells   10(5) 477-487   May 2005   [Refereed]
Hamamoto H, Kurokawa K, Kaito C, Kamura K, Manitra Razanajatovo I, Kusuhara H, Santa T, Sekimizu K
Antimicrobial Agents and Chemotherapy   48(3) 774-9   Mar 2004   [Refereed]
Ichihashi N, Kurokawa K, Matsuo M, Kaito C, Sekimizu K
The Journal of Biological Chemistry   278(31) 28778-28786   Aug 2003   [Refereed]
Kai M, Kaito C, Fukamachi H, Higo T, Takayama E, Hara H, Ohya Y, Igarashi K, Shiokawa K
Cell Research   13(3) 147-58   Jun 2003   [Refereed]
Matsuo M, Kurokawa K, Nishida S, Li Y, Takimura H, Kaito C, Fukuhara N, Maki H, Miura K, Murakami K, Sekimizu K
FEMS Microbiology Letters   222(1) 107-113   May 2003   [Refereed]
Kaito C, Akimitsu N, Watanabe H, Sekimizu K.
Microbial Pathogenesis   32(4) 183-90   Apr 2002   [Refereed]
Kaito C, Kurokawa K, Hossain MS, Akimitsu N, Sekimizu K.
FEMS Microbiology Letters   210(1) 157-164   Apr 2002   [Refereed]
Lancet   357(9264) 1225-1240   2001   [Refereed]
Kaito C, Kai M, Higo T, Takayama E, Fukamachi H, Sekimizu K, Shiokawa K.
Development, Growth and Differentiation   43(4) 383-390   2001   [Refereed]
Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology   126 149-55   2000   [Refereed]
Mitsutomi S, Akimitsu N, Sekimizu K, Kaito C
Biochimie   165 235-244   Aug 2019   [Refereed]

Research Grants & Projects

 
治療効果を指向した新規抗菌薬の創出
日本学術振興会: 基盤研究(S)
Project Year: 2015 - 2019
日本学術振興会: Grant-in-Aid for Challenging Exploratory Research
Project Year: 2016 - 2017    Investigator(s): Chikara Kaito
日本学術振興会: Grant-in-Aid for Scientific Research (B)
Project Year: 2015 - 2018
日本学術振興会: Grant-in-Aid for Scientific Research (B)
Project Year: 2015 - 2017
日本学術振興会: Grant-in-Aid for Challenging Exploratory Research
Project Year: 2014 - 2015
食用キノコに常在する微生物の生理的機能に関する研究
薬学振興会(公財): 基礎的研究助成
Project Year: 2015       Investigator(s): Chikara Kaito
日本学術振興会: 新学術領域研究(研究領域提案型)
Project Year: 2013 - 2014
日本学術振興会: 基盤研究(C)
Project Year: 2012 - 2014
黄色ブドウ球菌の細胞外毒素分泌トランスポーターの同定
野田産業科学研究所(公財): 野田産研研究助成 奨励研究助成
Project Year: 2014       Investigator(s): Chikara Kaito
新規RNA 結合蛋白質群による細菌の病原性調節機構の理解
かなえ医薬振興財団: 研究助成金
Project Year: 2014       Investigator(s): Chikara Kaito
カイコ感染モデルを利用した宿主—病原体相互作用の理解
日本学術振興会: 基盤研究(A)
Project Year: 2011 - 2013    Investigator(s): 関水 和久 東京大学, 薬学系, 教授
細菌の潜在的病原性を規定する分子機構の解明
持田記念医学薬学振興財団: 研究助成金
Project Year: 2013       Investigator(s): Chikara Kaito
大腸菌の高病原性化をひきおこす分子機構の解明
薬学研究奨励財団: 研究助成金 グループA
Project Year: 2013       Investigator(s): Chikara Kaito
カイコ感染モデルを基盤とした細菌の病原性発現システムの解明
日本学術振興会: 基盤研究(B)
Project Year: 2008 - 2010    Investigator(s): 関水 和久 東京大学, 薬学系, 教授
Research on virulence regulatory mechanisms by CVF
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2008 - 2009    Investigator(s): Chikara KAITO
内藤記念科学振興財団: 内藤記念科学奨励金
Project Year: 2009   
カイコ感染モデルを用いたグラム陽性細菌に保存された病原性発現機構の解明
日本学術振興会: 特定領域研究
Project Year: 2007 - 2008    Investigator(s): 関水 和久 東京大学, 薬学系, 教授
日本学術振興会: 若手研究(B)
Project Year: 2006 - 2007
Colony Spreading in Staphylococcus aureus
Project Year: 2007   
黄色ブドウ球菌の滑走能低下を指標とした抗菌治療薬に関する研究
日本学術振興会: 萌芽研究
Project Year: 2007       Investigator(s): 関水 和久 東京大学, 薬学系, 教授
カイコ感染モデルを用いた新規病原性遺伝子の同定
JST: シーズ発掘試験研究
Project Year: 2006       Investigator(s): Chikara Kaito
黄色ブドウ球菌の滑走能を規定する遺伝子群の探索
薬学振興会(公財): 基礎的研究助成
Project Year: 2006       Investigator(s): Chikara Kaito
Identification of novel virulence genes usig a silkworm model

Books etc

 
非ほ乳動物を用いた感染モデル
Chikara Kaito
2017   
細菌間で保存された機能未知因子群からの新規病原性因子の同定
Chikara Kaito
化学療法の領域 32(5):126-131. 医薬ジャーナル社   2016   
黄色ブドウ球菌の病原性制御機構に関する研究
Chikara Kaito
日本細菌学雑誌 69(3):491-501. 日本細菌学会   2014   
メチシリン耐性黄色ブドウ球菌のコロニースプレッディングおよび病原性発現調節を担う新規遺伝子「fudoh」
Chikara Kaito
感染・炎症・免疫 39(3):71-75. 医学の門社   2009   
MRSAに見出された新規遺伝子「不動」
Chikara Kaito
化学療法の領域 25(8):46-53. 医薬ジャーナル社   2009   

Patents

 
特開WO2009-154016 : 病原性細菌の病原性を評価する方法、病原性の評価用キット及び病原性評価用遺伝子
特開特開2008-148669 : 感染症の予防又は治療のための薬剤及びその製造方法、評価方法及びスクリーニング方法、並びに、病原性細菌の病原異性の評価方法及び感染症の検査方法

Social Contribution

 
墨田区医師会立看護専門学校 生化学講義(地域医療人材育成)
[Lecturer]

Conference Activities & Talks

 
A Novel Gene fudoh in SCCmec Region Regulates the Colony Spreading Ability and Virulence in Staphylococcus aureus
13th International Symposium on Staphylococci and Staphylococcal Infections   2008   
Surface Motility of Staphylococcus aureus on soft agar plates
12th International Symposium on Staphylococci and Staphylococcal Infections   2006   
Silkworm-Pathogenic Bacteria Infection Model for Identificaiton of Novel Virulence Genes
105th General Meeting (American Society for Microbiology)   2005   
Silkworm Larvae as an Animal Model of Infection with Staphylococcus aureus
10th International Symposium on Staphylococci and Staphylococcal Infections   2002