HOSOI Yoshio

J-GLOBAL         Last updated: Apr 1, 2019 at 12:29
HOSOI Yoshio

Published Papers

Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217.
Hashimoto T, Murata Y, Urushihara Y, Shiga S, Takeda K, Hosoi Y
Biochemical and Biophysical Research Communications   495 2566-2572   2018   [Refereed]
Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways.
Hashimoto T, Murata Y, Urushihara Y, Shiga S, Takeda K, Hosoi Y
Biochemical and Biophysical Research Communications   505 13-19   2018   [Refereed]
A chemical modulator of p53 transactivation that acts as a radioprotective agonist.
Morita A, Takahashi I, Sasatani M, Aoki S, Wang B, Ariyasu S, Tanaka K, Yamaguchi T, Sawa A, Nishi Y, Teraoka T, Ujita S, Kawate Y, Yanagawa C, Tanimoto K, Enomoto A, Nenoi M, Kamiya K, Nagata Y, Hosoi Y, Inaba T
Mol Cancer Ther   17 432-442   2018   [Refereed]
NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells.
Uehara Y, Murata Y, Shiga S, Hosoi Y
Biochemical and Biophysical Research Communications   479 847-852   2016   [Refereed]
A diarylpentanoid curcumin analog exhibits improved radioprotective potential in the intestinal mucosa.
Fukuda K, Uehara Y, Nakata E3, Inoue M, Shimazu K, Yoshida T, Kanda H, Nanjo H5, Hosoi Y, Yamakoshi H, Iwabuchi Y, Shibata H
International Journal of Radiation Biology   92 388-394   2016   [Refereed]
Inhibition of β-catenin and STAT3 with curcumin analog suppresses gastric carcinogenesis in vivo: a novel candidate for gastric cancer treatment.
Uehara Y, Inoue M, Fukuda K, Yamakoshi H, Hosoi Y, Kanda H, Oshima M, Iwabuchi Y, Shibata H
Gastric Cancer   18 774-783   2015   [Refereed]
Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6.
Murata Y, Uehara Y, Hosoi Y
Biochemical and Biophysical Research Communications   468 684-690   2015   [Refereed]
Requirement of mitochondria for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line HepG2 cells.
Morita A, Murakami T, Morinaga T, Tanimoto K, Hosoi Y
Biochemical and Biophysical Research Communications   443 1286-1290   2014   [Refereed]
Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice.
Wang B, Tanaka K, Morita A, Ninomiya Y, Maruyama K, Fujita K, Hosoi Y, Nenoi M
J. Radiat. Res.   54 620-651   2013   [Refereed]
The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition.
Enomoto A, Fukasawa T, Takamatsu N, Itob M, Moritac A, Hosoi Y, Miyagawa K
European Journal of Cancer   49 2439-2450   2013   [Refereed]
Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis.
Morita A, Ariyasu S, Ohya S, Takahashi I, Wang B, Tanaka K, Uchida T, Okazaki H, Hanaya K, Enomoto A, Nenoi M, Ikekita M, Aoki S, Hosoi Y
Oncotarget   4 2439-2450   2013   [Refereed]
Loss of life after evacuation: lessons learned from the Fukushima accident.
Tanigawa K, Hosoi Y, Hirohashi N, Iwasaki Y, Kamiya K
Lancet   379 889-891   2012   [Refereed]
A Step forward into respiratory genetics: Overview contribution of genetics in respiratory diseases.
Putra AC, Tanimoto K, Syahruddin E, Andarini S, Hosoi Y, Hiyama K
Asian Biomedicine   5 639-651   2012   [Refereed]
Evacuation from the restricted zone of the damaged Fukushima nuclear power plant; facing with the reality.
Tanigawa K, Hosoi Y, Hirohashi N, Iwasaki Y, Kamiya
Resuscitation   82 1248-1248   2011   [Refereed]
Sodium orthovanadate inhibits p53-mediated apoptosis.
Morita A, Yamamoto S, Sang B, Tanaka, K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, Hosoi Y, Ikekita M
Cancer Research   293 52-57   2010   [Refereed]
Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.
Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Morita A, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
Cancer Letters   293 52-57   2010   [Refereed]
Umami taste dysfunction in patients receiving radiotherapy for head and neck cancer.
Yamashita H, Nakagawa K, Hosoi Y, Kurokawa A., Fukuda Y, Matusmoto I, Misaka T, Abe K
Oral Oncology   45 19-23   2009   [Refereed]
Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform-dependent manner.
Oyama S, Yamakawa H, Sasagawa N, Hosoi Y, Futai E, Ishiura S
PloS ONE   4 e4199 1-12   2009   [Refereed]
Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38 (STK38).
Enomoto A, Kido N, Ito M, Morita A, Matsumoto Y, Takamatsu N, Hosoi Y, Miyagawa K
Oncogene   27 1930-1938   2008   [Refereed]
Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident.
Igaki H, Nakagawa K, Uozaki H, Akahane M, Hosoi Y, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K
Journal of Radiation Research   49 55-62   2008   [Refereed]
Preoperative radiation response evaluated by 18-Fluorodeoxyglucose positron emission tomography predicts survival in locally advanced rectal cancer.
Nakagawa K, Yamashita H, Nakamura N, Igaki H, Tago M, Hosoi Y, Momose T, Ohtomo K, Muto T, Nagawa H
Dis Colon Rectum   51 1055-1060   2008   [Refereed]
Free radical scavenger Edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells.
Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
Journal of Radiation Research   48 495-503   2007   [Refereed]
Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53.
Morita A, Zhu J, Suzuki N, Enomoto A, Matsumoto Y, Tomita T, Suzuki T, Ohtomo K, Hosoi Y
Cell Death and Differentiation   13 499-511   2006   [Refereed]
The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.
Someya M, Sakata K, Matsumoto Y, Yamamoto H, Monobe M, Ikeda H, Aono K, Hosoi Y, Suzuki N, Hareyama M
Carcinogenesis   27 117-122   2006   [Refereed]
Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.
Li Z, Hosoi Y, Cai K, Tanno Y, Matsumoto Y, Enomoto A, Morita A, Nakagawa K, Miyagawa K
Biochemical and Biophysical Research Communications   342 363-368   2006   [Refereed]
Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation: a report of two successful cases.
Nakagawa K, Kanda Y, Yamashita H, Hosoi Y, Oshima K, Ohtomo I, Ban N, Yamakawa, S, Nakagawa S, Chiba S
Bone Marrow Transplantation   37 583-587   2006   [Refereed]
Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.
Tonotsuka N, Hosoi Y, Miyazaki S, Miyata G, Sugawara K, Mori T, Ouchi N, Satomi S, Matsumoto Y, Nakagawa K, Miyagawa K, Ono T
International Journal of Molecular Medicine   18 441-447   2006   [Refereed]
Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC.
Hosoi Y, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K
Biochemical and Biophysical Research Communications   348 728-734   2006   [Refereed]
Relation between acute & late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head and neck cancer.
Yamashita H, Nakamura N, Abe K, Asakage T, Ohmoto M, Okada S, Matsumoto I, Hosoi Y, Sasano N, Yamakawa S, Ohtomo K, Nakagawa K
International Journal of Radiation Oncology Biology Physics   66 1422-1429   2006   [Refereed]
Prognostic significance of Ku70 protein expression in patients with advanced colorectal cancer.
Komuro Y, Watanabe T, Hosoi Y, Matsumoto Y, Nakagawa K, Suzuki N, Nagawa H
Hepato-Gastroenterology   52 995-998   2005   [Refereed]
Effect of nitric oxide on γ-ray-induced micronucleus frequency in RAW264.7 cells.
Tokuzumi S, Hori M, Monobe M, Hosoi Y, Kojima S
Radiation Research   164 723-732   2005   [Refereed]
Radiation thrapy for portal venous invasion by hepatocellular carcinoma.
Nakagawa K, Yamashita H, Shiraishi K, Nakamura N, Tago M, Igaki H, Hosoi Y, Shiina S, Omata M, Makuuchi M, Ohtomo I
World Journal of Gastroenterology   11 7237-7241   2005   [Refereed]
Suramin sensitizes cells to ionizing radiation by inactivating DNA-dependent protein kinase.
Hosoi Y, Matsumoto Y, Enomoto A, Morita A, Green J, Nakagawa K, Naruse K, Suzuki N
Radiation Research   162 308-314   2004   [Refereed]
Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.
Hosoi Y, Watanabe T, Nakagawa K, Matsumoto Y, Enomoto A, Morita A, Nagawa H, Suzuki N
International Journal of Oncology   25 461-468   2004   [Refereed]
Spontaneous mutations in Digestive tract of old mice show tissue-specific patterns of genomic instability.
Ono T, Ikehata H, Pithani VP, Uehara Y, Chen Y, Kinouchi Y, Shimosegawa Y, Hosoi Y
Cancer Research   64 6919-6923   2004   [Refereed]
Radiosensitization by hyperthermia in the chicken B-lymphocyte cell line DT40 and its derivatives lacking nonhomologous end joining and/or homologous recombination pathways of DNA double-strand break repair.
Yin HL, Suzuki Y, Matsumoto Y, Tomita M, Furusawa Y, Enomoto A, Morita A, Aoki M, Yatagai F, Suzuki T, Hosoi Y, Ohtomo K, Suzuki N
Radiation Research   162 433-441   2004   [Refereed]
Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.
Komiyama S, Taniguchi S, Matsumoto Y, Tsunoda E, Ohto T, Suzuki Y, Yin HL, Tomita M, Enomoto A, Morita A, Suzuki T
Biochemical and Biophysical Research Communications   323 816-822   2004   [Refereed]
Wortmannin enhanced X-ray-induced apoptotic cell death through JNK/SAPK activation in human T-cell leukemia MOLT-4 cells.
Tomita M, Suzuki N, Matsumoto Y, Enomoto A, Yin HL, Hosoi Y, Hirano K, Sakai K
Radiation Research   160 467-477   2003   [Refereed]
Decreased c-Myc expression involved in X-ray-induced apoptotic cell death of human T-cell leukemia cell line MOLT-4.
Enomoto A, Suzuki N, Kang Y, Hirano K, Zhu J, Morita A, Matsumoto Y, Hosoi Y, Sakai K, Koyama H
International Journal of Radiation Biology. International Journal of Radiation Biology   79 589-600   2003   [Refereed]
Difference in the heat sensitivity of DNA-dependent protein kinase activity among mouse, hamster and human cells.
Umeda N, Matsumoto Y, Yin HL, Tomita M, Enomoto A, Morita A, Mizukoshi T, Sakai K, Hosoi Y, Suzuki N
International Journal of Radiation Biology   79 671-680   2003   [Refereed]
Caspase-mediated cleavage of JNK during stress-induced apoptosis.
Enomoto A, Suzuki N, Morita A, Ito M, Liu CQ, Matsumoto Y, Yoshioka K, Shiba T, Hosoi Y
Biochemical and Biophysical Research Communications   306 837-842   2003   [Refereed]
Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and Ku70 expression.
Komuro Y, Watanabe T, Hosoi Y, Matsumoto Y, Nakagawa K, Saito S, Ishihara S, Kazama S, Tsuno N, Kitayama J, Suzuki N, Tsurita G, Muto T, Nagawa H
J. Exp. Clin. Cancer Res.   22 223-228   2003   [Refereed]
Intercomparison of dose distribution between gamma knife and C-arm-mounted Linac.
Nakagawa K, Tago M, Shibata K, Nakamura N, Yamashita H, Shiraishi K, Terahara A, Kato D, Kato S, Hosoi Y, Shin M, Ohtomo K
Radiation Medicine   21 178-182   2003   [Refereed]
Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity.
Hosoi Y, Matsumoto Y, Tomita M, Enomoto A, Morita A, Sakai K, Nakagawa K, Umeda N, Zhao HJ, Ono T, Suzuki N
British Journal of Cancer   86 1143-1149   2002   [Refereed]
Roles of DNA-dependent protein kinase and ATM in cell-cycle dependent radiation sensitivity in human cells.
Yoshida M, Hosoi Y, Miyachi H, Ishii N, Matusmoto Y, Enomoto A, Nakagawa K, Yamada S, Suzuki N, Ono T
International Journal of Radiation Biology   78 503-512   2002   [Refereed]
Insulin-like growth factor I receptor is expressed at normal levels in Nijmegen breakage syndrome cells.
Watanabe H, Yu D, Sasaki T, Shibuya H, Hosoi Y, Asada M, Komatsu K, Miura M
Biochemical and Biophysical Research Communications   296 62-66   2002   [Refereed]
The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma.
Komuro Y, Watanabe T, Hosoi Y, Nakagawa K, Tsuno N, Kazama S, Kitayama J, Suzuki N, Nagawa H
Cancer   95 1199-1205   2002   [Refereed]
Induction of interleukin-1β mRNA by low doses of ionizing radiation in macrophages.
Hosoi Y, Miyachi H, Matsumoto Y, Enomoto Y, Nakagawa K, Suzuki N, Ono T
International Journal of Cancer   96 270-276   2001   [Refereed]
Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues.
Sakata K, Matsumoto Y, Tauchi H, Satoh M, Oouchi A, Nagakura H, Koito K, Hosoi Y, Suzuki N, Komatsu K, Hareyama M
International Journal of Radiation Oncology, Biology and Phsics   49 161-167   2001   [Refereed]
Radiological findings of accidental radiation injury of the fingers: A case report.
Nakagawa K, Kozuka T, Akahane M, Suzuki G, Akashi M, Hosoi Y, Aoki Y, Ohtomo K
Health physics   80 67-79   2001   [Refereed]
A new bisphosphonate treatment option for giant cell tumors.
Fujimoto N, Nakagawa k, Seichi A, Terahara A, Tago M, Aoki Y, Hosoi Y
Oncology Reports   8 643-647   2001   [Refereed]
Mapping psoralen cross-links at the nucleotide level in mammalian cells: Suppression of cross-linking at transcription factor- or nucleosome-biding sites.
Komura J, Ikehata H, Hosoi Y, Riggs AD, Ono T
Biochemistry   40 4096-4105   2001   [Refereed]
Radiation therapy for loco-regionally recurrent esophageal cancer after surgery.
Nemoto K, Ariga H, Kakuto Y, Matsushita H, Takeda K, Takahashi C, Takai Y, Yamada S, Hosoi Y
Radiotherapy and Oncology   61 165-168   2001   [Refereed]
A pilot study of radiation therapy combined with daily low-dose cisplatin for esophageal cancer.
Nemoto K, Ogawa Y, Matsushita H, Takeda K, Takahashi C, Saito H, Takai Y, Yamada S, Hosoi Y
Oncology Reports   8 785-789   2001   [Refereed]
Involvement of c-June NH2-terminal kinase-1 in heat-induced apoptotic cell death of human monoblastic leukaemia U937 cells.
Enomoto A, Suzuki N, Liu C, Kang Y, Zhu J, Serizawa S, Matsumoto Y, Morita A, Ito M, Hosoi Y
International journal of Radiation Biology   77 867-874   2001   [Refereed]
Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas.
Sakata K, Matusmoto Y, Satoh M, Oouchi A, Nagakura H, Koito K, Hosoi Y, Hareyama M, Suzuki N
Radiation Medicine   19 93-97   2001   [Refereed]
Ceavage and phosphorylation of XRCC4 protein induced by X-irradiation.
Matsumoto Y, Suzuki N, Namba N, Umeda N, Ma XJ, Morita,A, Tomita M, Enomoto S, Serizawa S, Hirano K, Sakai K, Yasuda H, Hosoi Y
FEBS Letters   478 67-71   2000   [Refereed]
Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse.
Ono T, Ikehata H, Nakamura S, Saito Y, Hosoi Y, Takai Y, Yamada S, Onodera J, Yamamoto K
Mutation Research   447 165-177   2000   [Refereed]
DNA-dependent protein kinase activity correlates with Ku70 expression and radiation sensitivity in esophageal cancer cell lines.
Zhao HJ, Hosoi Y, Miyachi H, Ishii K, Yoshida M, Nemoto K, Takai Y, Yamada S, Suzuki N, Ono T
Clinical Cancer Research   6 1073-1078   2000   [Refereed]
Radiation-induced mutation in spleen and brain of plasmid-based lacZ transgenic mouse.
Nakamura S, Ikehata H, Komura J, Hosoi Y, Inoue H, Gondo Y, Yamamoto K, Ichimasa Y, Ono T
International Journal of Radiation Biology   76 431-440   2000   [Refereed]
Molecular nature of mutations induced by a high dose of X-rays in spleen, liver, and brain of the lacZ-transgenic mouse.
Ono T, Ikehata H, Nakamura S, Saito Y, Komura J, Hosoi Y, Yamamoto K
Environmental and Molecular Mutagenesis   34 97-105   1999   [Refereed]
A phosphatidylinositol 3-kinase inhibitor wortmannin induces radio-resistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation.
Hosoi Y, Miyachi H, Matsumoto Y, Ikehata H, Komura J, Ishii K, Zhao, HJ, Yoshida M, Takai Y, Yamada S, Suzuki N, Ono T
International Journal of Cancer   78 642-647   1998   [Refereed]
Sensitization of cells to ionizing radiation by chlorin e6Na.
Hosoi Y, Kawamura M, Ido T, Takai Y, Ishii K, Nemoto K, Ono T, Kimura S, Sakamoto K
Radiation Oncology Investigation   6 151-156   1998   [Refereed]
Fundamental and clinical studies on cancer control with total or upper half body irradiation.
Sakamoto K, Myojin M, Hosoi Y, Ogawa Y, Nemoto K, Takai Y, Kakuto Y, Yamada Y, Yatabe N
Journal of Japanese Society for Therapeutic Radiology and Oncology   9 161-175   1997   [Refereed]
Single dose radiocurability of four murine solid tumors and a predictive assay for the curability in situ.
Takai Y, Hosoi, Y, Sakamoto K, Okada S
Journal of Radiation Research   38 233-240   1997   [Refereed]
Effect of combination treatment of 15 cGy total body irradiation and OK-432 on spontaneous lung metastasis and mitogenic response of splenocyte in mice.
Hosoi Y, Ishii K, Yamada S, Ono T, Sakamoto K
Radiation Oncology Investigations   5 283-288   1997   [Refereed]
X-ray- and ultraviolet-radiation-induced mutation in MutaTM mouse.
Ono T, Ikehata H, Hosoi Y, Son BS, Kurishita A, Yamamoto K, Suzuki T
Radiation Research   148 123-128   1997   [Refereed]
Enhanced proliferation and IL-1 production of mouse splenocytes by low dose whole body X-irradiation.
Ishii Y, Hosoi Y, Ono T, Sakamoto K
Physiol. Chem. Phys & Med. NMR   28 7-14   1996   [Refereed]
Decreased incidence of thymic lymphoma in AKR mice as a result of chronic fractionated low-dose total body X-irradiation.
Ishii K, Hosoi Y, Yamada S, Ono T, Sakamoto K
Radiation Research   146 582-585   1996   [Refereed]
Non-destructive elemental analysis of vertebral body trabecular bone using muonic X-rays.
Hosoi Y, Watanabe Y, Sugita R, Tanaka Y, Nagamine K, Ono T, Sakamoto K
British Journal of Radiology   68 1325-1331   1995   [Refereed]
Expression of a candidate ataxia-telangiectasia group D gene in cultured fibroblast cell lines and human tissues.
Hosoi Y, Kapp Y
International Journal of Radiation Biology   66 s71-s76   1994   [Refereed]
Prostacyclin production in cultured endothelial cells is highly sensitive to low doses of ionizing radiation.
Hosoi Y, Yamamoto M, Ono T, Sakamoto K
International Journal of Radiation Biology   63 631-638   1993   [Refereed]
Suppressive effect of low dose total body irradiation on lung metastasis: dose dependency and effective period.
Hosoi Y, Sakamoto K
Radiotherapy and Oncology   26 177-179   1993   [Refereed]
Effect of recombinant human granulocyte colony-stimulating factor on survival in lethally irradiated mice.
Hosoi Y, Ono T, Sakamoto K
Acta Oncologica   31 59-63   1992   [Refereed]
Effect of low dose total body irradiation on artificail lung metastasis.
Hosoi Y, Sakamoto K, Ono T
Yokohama Med. Bull.   42 3-4   1991   [Refereed]