論文

査読有り
2019年11月

Gene Composition as a Potential Barrier to Large Recombinations in the Bacterial Pathogen Klebsiella pneumoniae.

Genome Biol Evol
  • Francesco Comandatore
  • ,
  • Davide Sassera
  • ,
  • Sion C Bayliss
  • ,
  • Erika Scaltriti
  • ,
  • Stefano Gaiarsa
  • ,
  • Xiaoli Cao
  • ,
  • Ana C Gales
  • ,
  • Ryoichi Saito
  • ,
  • Stefano Pongolini
  • ,
  • Sylvain Brisse
  • ,
  • Edward J Feil
  • ,
  • Claudio Bandi

11
11
開始ページ
3240
終了ページ
3251
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/gbe/evz236

Klebsiella pneumoniae (Kp) is one of the most important nosocomial pathogens worldwide, able to cause multiorgan infections and hospital outbreaks. One of the most widely disseminated lineage of Kp is the clonal group 258 (CG258), which includes the highly resistant "high-risk" sequence types ST258 and ST11. Genomic investigations revealed that very large recombination events have occurred during the emergence of Kp lineages. A striking example is provided by ST258, which has undergone a recombination event that replaced over 1 Mb of the genome with DNA from an unrelated Kp donor. Although several examples of this phenomenon have been documented in Kp and other bacterial species, the significance of these very large recombination events for the emergence of either hypervirulent or resistant clones remains unclear. Here, we present an analysis of 834 Kp genomes that provides data on the frequency of these very large recombination events (defined as those involving >100 kb), their distribution within the genome, and the dynamics of gene flow within the Kp population. We note that very large recombination events occur frequently, and in multiple lineages, and that the majority of re

リンク情報
DOI
https://doi.org/10.1093/gbe/evz236
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31665331