論文

査読有り
2019年11月

Molecular epidemiologic and clinical analysis of Helicobacter cinaedi bacteremia in Japan.

Helicobacter
  • Yoko Nukui
  • ,
  • Takashi Chino
  • ,
  • Chihiro Tani
  • ,
  • Kazunari Sonobe
  • ,
  • Yoshibumi Aiso
  • ,
  • Shuji Tohda
  • ,
  • Ryuji Koike
  • ,
  • Ryoichi Saito

開始ページ
e12675
終了ページ
e12675
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/hel.12675

Helicobacter cinaedi is an important pathogen that causes bloodstream infections. Owing to the challenges in its culture and identification, its clinical and bacterial characteristics remain unknown. Our study aimed to investigate the molecular epidemiology and antimicrobial susceptibility of H cinaedi.<br />
From 2003 to 2016, we analyzed 16 non-repetitive H cinaedi strains, isolated from blood, at the medical hospital of Tokyo Medical and Dental University. Multilocus sequence typing was performed to analyze the genetic relationship across the different isolates. The minimum inhibitory concentrations (MIC) of antibiotics were determined by the agar dilution method.<br />
values of amoxicillin, gentamycin, imipenem, ciprofloxacin, and clarithromycin were 4, 0.5, 0.25, 64, and 128 mg/L, respectively.<br />
Since there is no recommended guideline yet for the choice or duration of antibiotic therapy and antimicrobial break points, our results suggested, for the first time, that prolonged antibiotic therapy, except with ciprofloxacin and clarithromycin, would be required to ensure resolution of symptoms and prevention of recurrence.

リンク情報
DOI
https://doi.org/10.1111/hel.12675
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31755167