We have investigated the isoscalar giant resonances in the Sn isotopes using inelastic scattering of 386-MeV alpha particles at extremely forward angles, including 0 degrees. We have obtained completely "background-free" inelastic-scattering spectra for the Sn isotopes over the angular range 0 degrees-9 degrees and up to an excitation energy of 31.5 MeV. The strength distributions for various multipoles were extracted by a multipole decomposition analysis based on the expected angular distributions of the respective multipoles. We find that the centroid energies of the isoscalar giant monopole resonance (ISGMR) in the Sn isotopes are significantly lower than the theoretical predictions. In addition, based on the ISGMR results, a value of K-tau = -550 +/- 100 MeV is obtained for the asymmetry term in the nuclear incompressibility. Constraints on interactions employed in nuclear structure calculations are discussed on the basis of the experimentally obtained values for K-infinity and K-tau.