佐井君江 (Kimie Sai) - マイポータル

基本情報

所属: 厚生労働省国立医薬品食品衛生研究所医薬安全科学部第一室室長

学位: 博士（医学）(東北大学)

J-GLOBAL ID: 200901030957956283
researchmap会員ID: 5000092279

研究キーワード

研究分野

学歴

委員歴

- 現在

日本薬物動態学会, 評議員

受賞

2016年12月

優秀演題賞, 東及び東南アジア地域における薬物動態・薬力学関連ゲノムバイオマーカーの民族差, 日本臨床薬理学会学術総会

佐井君江今任拓也, 望月淑恵, 伊藤幸子, 斎藤嘉朗

論文

Association between dipeptidyl peptidase-4 inhibitors and urinary tract infection in elderly patients: A retrospective cohort study.

Takuya Imatoh, Takumi Nishi, Midori Yasui, Toshiki Maeda, Kimie Sai, Yoshiro Saito, Hiroshi Une, Akira Babazono

Pharmacoepidemiology and drug safety 27(8) 931-939 2018年8月査読有り
Identification of risk factors and development of detection algorithm for denosumab-induced hypocalcaemia.

Imatoh T, Sai K, Takeyama M, Hori K, Karayama M, Furuhashi K, Segawa K, Kimura M, Kawakami J, Saito Y

Journal of clinical pharmacy and therapeutics 44(1) 62-68 2018年8月査読有り
Association between infection and severe drug adverse reactions: an analysis using data from the Japanese Adverse Drug Event Report database

Takuya Imatoh, Kimie Sai, Chisato Fukazawa, Yasushi Hinomura, Ryosuke Nakamura, Yoshimi Okamoto-Uchida, Katsunori Segawa, Yoshiro Saito

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 73(12) 1643-1653 2017年12月査読有り
Influence of Japanese Regulatory Action on Denosumab-Related Hypocalcemia Using Japanese Adverse Drug Event Report Database

Mayu Takeyama, Kimie Sai, Takuya Imatoh, Katsunori Segawa, Noriyasu Hirasawa, Yoshiro Saito

BIOLOGICAL & PHARMACEUTICAL BULLETIN 40(9) 1447-1453 2017年9月査読有り
Effect of Infectious Diseases on the Pathogenesis of Stevens Johnson Syndrome and Toxic Epidermal Necrolysis

Yoshimi Okamoto-Uchida, Ryosuke Nakamura, Kimie Sai, Takuya Imatoh, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito

BIOLOGICAL & PHARMACEUTICAL BULLETIN 40(9) 1576-1580 2017年9月査読有り
A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients

Kimie Sai, Kouji Kajinami, Hironobu Akao, Mizuho Iwadare, Ryoko Sato-Ishida, Yasuyuki Kawai, Kenji Takeda, Takashi Tanimoto, Takashi Yamano, Takashi Akasaka …

DRUG METABOLISM AND PHARMACOKINETICS 31(6) 467-470 2016年12月査読有り
Construction of possible integrated predictive index based on EGFR and ANXA3 polymorphisms for chemotherapy response in fluoropyrimidine-treated Japanese gastric cancer patients using a bioinformatic method

Hiro Takahashi, Nahoko Kaniwa, Yoshiro Saito, Kimie Sai, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Yasuhiro Matsumura, Atsushi Ohtsu, Takayuki Yoshino …

BMC CANCER 15 718 2015年10月査読有り
Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients

Tadaaki Hanatani, Kimie Sai, Masahiro Tohkin, Katsunori Segawa, Yoshiro Saito

International Journal of Clinical Pharmacy 37(3) 537-545 2015年6月査読有り
A detection algorithm for drug-induced liver injury in medical information databases using the Japanese diagnostic scale and its comparison with the Council for International Organizations of Medical Sciences/the Roussel Uclaf Causality Assessment Method scale

Tadaaki Hanatani, Kimie Sai, Masahiro Tohkin, Katsunori Segawa, Michio Kimura, Katsuhito Hori, Junichi Kawakami, Yoshiro Saito

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY 23(9) 984-988 2014年9月査読有り
High-temperature calcined fullerene nanowhiskers as well as long needle-like multi-wall carbon nanotubes have abilities to induce NLRP3-mediated IL-1β secretion.

Cui H, Wu W, Okuhira K, Miyazawa K, Hattori T, Sai K, Naito M, Suzuki K, Nishimura T, Sakamoto Y …

Biochemical and biophysical research communications 452(3) 593-599 2014年9月査読有り
Application of a Combination of a Knowledge-Based Algorithm and 2-Stage Screening to Hypothesis-Free Genomic Data on Irinotecan-Treated Patients for Identification of a Candidate Single Nucleotide Polymorphism Related to an Adverse Effect

Hiro Takahashi, Kimie Sai, Yoshiro Saito, Nahoko Kaniwa, Yasuhiro Matsumura, Tetsuya Hamaguchi, Yasuhiro Shimada, Atsushi Ohtsu, Takayuki Yoshino, Toshihiko Doi …

PLOS ONE 9(8) e105160 2014年8月査読有り
Distal Promoter Regions Are Responsible for Differential Regulation of Human Orosomucoid-1 and-2 Gene Expression and Acute Phase Responses

Kimie Sai, Kouichi Kurose, Tomoko Koizumi, Noriko Katori, Jun-ichi Sawada, Yasuhiro Matsumura, Nagahiro Saijo, Noboru Yamamoto, Tomohide Tamura, Haruhiro Okuda …

BIOLOGICAL & PHARMACEUTICAL BULLETIN 37(1) 164-168 2014年1月査読有り
Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data

Hiro Takahashi, Nahoko Kaniwa, Yoshiro Saito, Kimie Sai, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Yasuhiro Matsumura, Atsushi Ohtsu, Takayuki Yoshino …

Journal of Bioscience and Bioengineering 116(6) 768-773 2013年12月査読有り
Biomarker exploration and its clinical use

Yoshiro Saito, Kimie Sai, Nahoko Kaniwa, Yoko Tajima, Masaki Ishikawa, Tomoko Nishimaki-Mogami, Keiko Maekawa

Yakugaku Zasshi 133(12) 1373-1379 2013年査読有り
Significant Association between Hand-Foot Syndrome and Efficacy of Capecitabine in Patients with Metastatic Breast Cancer

Yuichiro Azuma, Kojiro Hata, Kimie Sai, Ryoko Udagawa, Akihiro Hirakawa, Masahiro Tohkin, Yasuaki Ryushima, Yoshinori Makino, Nobuaki Yokote, Norifumi Morikawa …

BIOLOGICAL & PHARMACEUTICAL BULLETIN 35(5) 717-724 2012年5月査読有り
[Trends in drug-induced liver injury based on reports of adverse reactions to PMDA in Japan].

Sudo C, Maekawa K, Segawa K, Hanatani T, Sai K, Saito Y

Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences (130) 66-70 2012年査読有り
Genetic Variations of Orosomucoid Genes Associated with Serum Alpha-1-Acid Glycoprotein Level and the Pharmacokinetics of Paclitaxel in Japanese Cancer Patients

Noriko Katori, Kimie Sai, Yoshiro Saito, Hiromi Fukushima-Uesaka, Kouichi Kurose, Chikako Yomota, Toru Kawanishi, Tomoko Nishimaki-Mogami, Mikihiko Naito, Jun-Ichi Sawada …

JOURNAL OF PHARMACEUTICAL SCIENCES 100(10) 4546-4559 2011年10月査読有り
Ethnic differences in the metabolism, toxicology and efficacy of three anticancer drugs

Kimie Sai, Yoshiro Saito

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 7(8) 967-988 2011年8月査読有り
Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein

Keiichiro Okuhira, Nobumichi Ohoka, Kimie Sai, Tomoko Nishimaki-Mogami, Yukihiro Itoh, Minoru Ishikawa, Yuichi Hashimoto, Mikihiko Naito

FEBS Letters 585(8) 1147-1152 2011年4月査読有り
Genetic Polymorphisms and Haplotypes of POR, Encoding Cytochrome P450 Oxidoreductase, in a Japanese Population

Yoshiro Saito, Noboru Yamamoto, Noriko Katori, Keiko Maekawa, Hiromi Fukushima-Uesaka, Daisuke Sugimoto, Kouichi Kurose, Kimie Sai, Nahoko Kaniwa, Jun-ichi Sawada …

DRUG METABOLISM AND PHARMACOKINETICS 26(1) 107-116 2011年査読有り

もっとみる

MISC

Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients

Kimie Sai, Yoshiro Saito, Naoko Tatewaki, Masakiyo Hosokawa, Nahoko Kaniwa, Tomoko Nishimaki-Mogami, Mikihiko Naito, Jun-ichi Sawada, Kuniaki Shirao, Tetsuya Hamaguchi …

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 70(2) 222-233 2010年8月
Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients

Kimie Sai, Yoshiro Saito, Keiko Maekawa, Su-Ryang Kim, Nahoko Kaniwa, Tomoko Nishimaki-Mogami, Jun-ichi Sawada, Kuniaki Shirao, Tetsuya Hamaguchi, Noboru Yamamoto …

CANCER CHEMOTHERAPY AND PHARMACOLOGY 66(1) 95-105 2010年5月
Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients

Kimie Sai, Yoshiro Saito, Hiromi Fukushima-Uesaka, Koichi Kurose, Nahoko Kaniwa, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Tetsuya Hamaguchi, Hideo Kunitoh …

CANCER CHEMOTHERAPY AND PHARMACOLOGY 62(3) 529-537 2008年8月
Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients

Kimie Sai, Yoshiro Saito, Hiromi Sakamoto, Kuniaki Shirao, Koichi Kurose, Mayumi Saeki, Shogo Ozawa, Nahoko Kaniwa, Setsuo Hirohashi, Nagahiro Saijo …

CANCER LETTERS 261(2) 165-171 2008年3月
日本人がん患者のイリノテカン個別化治療実現にむけて: UGT1A1遺伝子多型（*28および*6)の意義について

佐井君江, 澤田純一, 南博信

薬学雑誌 128(4) 575-584 2008年
Impact of UDP- glucuronosyltransferase 1A haplotypes on irinotecan treatment

Sai K, Minami H, Saito Y, Sawada JI

In: Cancer Drug Discovery and Development: Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response Humana Press 267-286 2008年
Impact of UDP- glucuronosyltransferase 1A haplotypes on irinotecan treatment

Sai K, Minami H, Saito Y, Sawada JI

In: Cancer Drug Discovery and Development: Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response Humana Press 267-286 2008年
Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and*28

Hironobu Minami, Kimie Sai, Mayumi Saeki, Yoshiro Saito, Shogo Ozawa, Kazuhiro Suzuki, Nahoko Kaniwa, Jun-ichi Sawada, Tetsuya Hamaguchi, Noboru Yamamoto …

PHARMACOGENETICS AND GENOMICS 17(7) 497-504 2007年7月
抗がん剤の副作用低減をめざして－イリノテカンのファ－マコジェネティクス－

佐井君江, 澤田純一

ファルマシア 41(1) 39-43 2005年
UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer

K Sai, M Saeki, Y Saito, S Ozawa, N Katori, H Jinno, R Hasegawa, N Kaniwa, J Sawada, K Komamura …

CLINICAL PHARMACOLOGY & THERAPEUTICS 75(6) 501-515 2004年6月
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan

K Sai, N Kaniwa, M Itoda, Y Saito, R Hasegawa, K Komamura, K Ueno, S Kamakura, M Kitakaze, K Shirao …

PHARMACOGENETICS 13(12) 741-757 2003年12月

所属学協会

共同研究・競争的資金等の研究課題

抗がん剤応答性の予測法開発と個別化医療への応用

2000年
Pharmacogenomic study on anti-cancer drugs

2000年