Sanbe Atsushi

Profile Information

Affiliation: School of Pharmacy, Iwate Medical University

Degree: 薬学博士(東京薬科大学)

J-GLOBAL ID: 200901062303787090
researchmap Member ID: 5000092317

External link: https://www.imu-pharm.jp

Research Interests

Research Areas

Life sciences / Pharmacology /

Research History

Apr, 2018 - Present

School of Pharmacy, Iwate Medical University
Apr, 2014 - Mar, 2018

School of Pharmacy, Iwate Medical University
Apr, 2010 - Mar, 2014

School of Pharmacy, Iwate Medical University
Jun, 2005 - Mar, 2010

国立成育医療センター研究所薬剤治療研究部実験薬理室室長
Oct, 2004 - May, 2005

シンシナティ大 / シンシナティ小児病院医学部分子心血管生物学部門アシスタントプロフェッサー
Sep, 2002 - Aug, 2004

シンシナティ大 / シンシナティ小児病院医学部分子心血管生物学部門インストラクター
Apr, 1997 - Apr, 2002

シンシナティ小児病院研究員
Apr, 1995 - Mar, 1997

田辺製薬株式会社研究員

Education

Apr, 1990 - Mar, 1995

Tokyo University of Pharmacy and Life Sciences
- 1990

School of Pharmacy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Awards

Nov, 2005

Young Investigator Award, CryAB R120G心筋症病態へのアミロイドオリゴマーの関与, 日本循環薬理学会

三部篤

Major Papers

124

Modification of cardiac disease by transgenically altered histone deacetylase 6

Atsushi Sanbe, Yui Inomata, Naoko Matsushita, Yohei Sawa, Chizuru Hino, Hinano Yamazaki, Kei Takanohashi, Natsuko Takahashi, Rieko Higashio, Hideki Tsumura …

Biochemical and Biophysical Research Communications, 631 48-54, Nov, 2022 Peer-reviewed
Chronic HDAC6 Activation Induces Atrial Fibrillation Through Atrial Electrical and Structural Remodeling in Transgenic Mice.

Yohei Sawa, Naoko Matsushita, Sachiko Sato, Nanae Ishida, Maki Saito, Atsushi Sanbe, Yoshihiro Morino, Eiichi Taira, Mami Obara, Masamichi Hirose

International heart journal, 62(3) 616-626, 2021
Rho/myocardin-related transcription factor A (MRTF-A) pathway plays an important role in TGF-β-induced epithelial mesenchymal transition in retinal pigment epithelial cells.

Tanaka U, Kurosaka D, Murai K, Hashizume K, Sanbe A

Journal of Iwate Medical Association., 72 217-230, Sep, 2020 Peer-reviewed
Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure.

Toshihiro Yamaguchi, Tomokazu S Sumida, Seitaro Nomura, Masahiro Satoh, Tomoaki Higo, Masamichi Ito, Toshiyuki Ko, Kanna Fujita, Mary E Sweet, Atsushi Sanbe …

Nature communications, 11(1) 4364-4364, Aug 31, 2020 Peer-reviewed
Topical administration of a ROCK inhibitor prevents anterior subcapsular cataract induced by UV-B irradiation.

Imaizumi T, Kurosaka D, Tanaka U, Sakai D, Fukuda K, Sanbe A

Experimental eye research, 181 145-149, Apr, 2019 Peer-reviewed
Chronic Pressure Overload Induces Cardiac Hypertrophy and Fibrosis via Increases in SGLT1 and IL-18 Gene Expression in Mice.

Naoko Matsushita, Nanae Ishida, Miho Ibi, Maki Saito, Atsushi Sanbe, Hisashi Shimojo, Satoshi Suzuki, Hermann Koepsell, Yasuchika Takeishi, Yoshihiro Morino …

International heart journal, 59(5) 1123-1133, Sep 26, 2018 Peer-reviewed
Bcl-2-associated athanogene 3 (BAG3) is an enhancer of small heat shock protein turnover via activation of autophagy in the heart

Yui Inomata, Shouta Nagasaka, Kazuki Miyate, Yuta Goto, Chizuru Hino, Chihiro Toukairin, Rieko Higashio, Kinji Ishida, Tomoyuki Saino, Masamichi Hirose …

Biochemical and Biophysical Research Communications, 496(4) 1141-1147, Feb 19, 2018 Peer-reviewed
Okuno T., Imaizumi T., Sakamoto U., Sakai D., Fukuda D., Sanbe A., Mayanagi T., Sobue K. and Kurosaka D. Myocardin-related transcription factor A (MRTF-A) regulates TGF-β2-induced type I collagen production in human lens epithelial cells.

Okuno T, Imaizumi T, Sakamoto U, Sakai D, Fukuda D, Sanbe A, Mayanagi T, Sobue K, Kurosaka D

70 81-90, 2018 Peer-reviewed
Protein folding disease and ATP sensitive potassium channel.

Sanbe A

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 146(1) 16-20, Jul, 2015 Peer-reviewed
Upregulation of inorganic pyrophosphatase 1 as a JNK phosphatase in hypothyroid embryonic chick cerebellum

Yu Tezuka, Natsumi Herai, Yui Inomata, Keisuke Kagami, Junji Yamauchi, Hideo Nishigori, Atsushi Sanbe

LIFE SCIENCES, 128 94-100, May, 2015 Peer-reviewed
Effect of Astaxanthin on Cataract Formation Induced by Glucocorticoids in the Chick Embryo

Sayano Ishikawa, Kouhei Hashizume, Hideo Nishigori, Yu Tezuka, Atsushi Sanbe, Daijiro Kurosaka

CURRENT EYE RESEARCH, 40(5) 535-540, May, 2015 Peer-reviewed
Foreword.

Sanbe A

Biological & pharmaceutical bulletin, 38(8) 1093, 2015 Peer-reviewed
alpha B-Crystallin R120G variant causes cardiac arrhythmias and alterations in the expression of Ca2+-handling proteins and endoplasmic reticulum stress in mice

Qibin Jiao, Atsushi Sanbe, Xingwei Zhang, Jun-Ping Liu, Susumu Minamisawa

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 41(8) 589-599, Aug, 2014 Peer-reviewed
αB-Crystallin R120G variant causes cardiac arrhythmias and alterations in the expression of Ca<sup>2+</sup>-handling proteins and endoplasmic reticulum stress in mice

Qibin Jiao, Atsushi Sanbe, Xingwei Zhang, Jun-Ping Liu, Susumu Minamisawa

Clinical and Experimental Pharmacology and Physiology, 41(8) 589-599, 2014 Peer-reviewed
Regulation of Neurite Growth by Inorganic Pyrophosphatase 1 via JNK Dephosphorylation

Yu Tezuka, Mizuki Okada, Yuka Tada, Junji Yamauchi, Hideo Nishigori, Atsushi Sanbe

PLOS ONE, 8(4) e61649, Apr, 2013 Peer-reviewed
Phenotype of Cardiomyopathy in Cardiac-specific Heat Shock Protein B8 K141N Transgenic Mouse

Atsushi Sanbe, Tetsuro Marunouchi, Tsutomu Abe, Yu Tezuka, Mizuki Okada, Sayuri Aoki, Hideki Tsumura, Junji Yamauchi, Kouichi Tanonaka, Hideo Nishigori …

JOURNAL OF BIOLOGICAL CHEMISTRY, 288(13) 8910-8921, Mar, 2013 Peer-reviewed
Dilated Cardiomyopathy: A Disease of the Myocardium

Atsushi Sanbe

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 36(1) 18-22, Jan, 2013 Peer-reviewed
Small heat shock protein related diseases and acetylated tubulin

Atsushi Sanbe

Seikagaku, 85(1) 13-20, 2013 Peer-reviewed
[Molecular mechanisms of small heat shock protein-related disease and its therapeutic strategies].

Sanbe A

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 139(6) 256-259, Jun, 2012 Peer-reviewed
Circadian rhythms govern cardiac repolarization and arrhythmogenesis

Darwin Jeyaraj, Saptarsi M. Haldar, Xiaoping Wan, Mark D. McCauley, Juergen A. Ripperger, Kun Hu, Yuan Lu, Betty L. Eapen, Nikunj Sharma, Eckhard Ficker …

NATURE, 483(7387) 96-U141, Mar, 2012 Peer-reviewed
Molecular Mechanisms of alpha-Crystallinopathy and Its Therapeutic Strategy

Atsushi Sanbe

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 34(11) 1653-1658, Nov, 2011 Peer-reviewed
Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

Jie Li, Kathleen M. Horak, Huabo Su, Atsushi Sanbe, Jeffrey Robbins, Xuejun Wang

JOURNAL OF CLINICAL INVESTIGATION, 121(9) 3689-3700, Sep, 2011 Peer-reviewed
The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination.

Junji Yamauchi, Yuki Miyamoto, Hajime Hamasaki, Atsushi Sanbe, Shinji Kusakawa, Akane Nakamura, Hideki Tsumura, Masahiro Maeda, Noriko Nemoto, Katsumasa Kawahara …

The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(35) 12579-92, Aug 31, 2011 Peer-reviewed
Functional Role of alpha(1)-Adrenoceptor Subtypes in Murine Ophthalmic Arteries

Adrian Gericke, Marcin L. Kordasz, Andreas Steege, Atsushi Sanbe, Evgeny Goloborodko, Jan M. Vetter, Andreas Patzak, Norbert Pfeiffer

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52(7) 4795-4799, Jun, 2011 Peer-reviewed
Cardioprotective Effect of Nicorandil, a Mitochondrial ATP-Sensitive Potassium Channel Opener, Prolongs Survival in HSPB5 R120G Transgenic Mice

Atsushi Sanbe, Tetsuro Marunouchi, Junji Yamauchi, Kouichi Tanonaka, Hideo Nishigori, Akito Tanoue

PLOS ONE, 6(4) e18922, Apr, 2011 Peer-reviewed
Inhibitory effects of cigarette smoke extract on neural crest migration occur through suppression of R-spondin1 expression via aryl hydrocarbon receptor

Atsushi Sanbe, Reiko Mizutani, Noriko Miyauchi, Junji Yamauchi, Takashi Nagase, Ken-ichi Yamamura, Akito Tanoue

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 380(6) 569-576, Dec, 2009 Peer-reviewed
Enhanced vascular contractility in alpha1-adrenergic receptor-deficient mice

Atsushi Sanbe, Yoshio Tanaka, Yoko Fujiwara, Noriko Miyauchi, Reiko Mizutani, Junji Yamauchi, Susanna Cotecchia, Katsuo Koike, Gozoh Tsujimoto, Akito Tanoue

LIFE SCIENCES, 84(21-22) 713-718, May, 2009 Peer-reviewed
Protective Effect of Geranylgeranylacetone via Enhancement of HSPB8 Induction in Desmin-Related Cardiomyopathy

Atsushi Sanbe, Takuya Daicho, Reiko Mizutani, Toshiya Endo, Noriko Miyauchi, Junji Yamauchi, Kouichi Tanonaka, Charles Glabe, Akito Tanoue

PLOS ONE, 4(4) e5351, Apr, 2009 Peer-reviewed
Alcohol preference in mice lacking the Avpr1a vasopressin receptor

Atsushi Sanbe, Norio Takagi, Yoko Fujiwara, Junji Yamauchi, Toshiya Endo, Reiko Mizutani, Satoshi Takeo, Gozoh Tsujimoto, Akito Tanoue

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 294(5) R1482-R1490, May, 2008 Peer-reviewed
Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure

J. Scott Pattison, Atsushi Sanbe, Alina Maloyan, Hanna Osinska, Raisa Klevitsky, Jeffrey Robbins

CIRCULATION, 117(21) 2743-2751, May, 2008 Peer-reviewed
Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations

Cordula M. Wolf, Michael Arad, Ferhaan Ahmad, Atsushi Sanbe, Scott A. Bernstein, Okan Toka, Tetsuo Konno, Gregory Morley, Jeffrey Robbins, J. G. Seidman …

CIRCULATION, 117(2) 144-154, Jan, 2008 Peer-reviewed
alpha(1)-adrenoceptors are required for normal male sexual function

A. Sanbe, Y. Tanaka, Y. Fujiwara, H. Tsumura, J. Yamauchi, S. Cotecchia, K. Koike, G. Tsujimoto, A. Tanoue

BRITISH JOURNAL OF PHARMACOLOGY, 152(3) 332-340, Oct, 2007 Peer-reviewed
Interruption of CryAB-Amyloid oligomer formation by HSP22

Atsushi Sanbe, Junji Yamauchi, Yuki Miyamoto, Yoko Fujiwara, Mayu Murabe, Akito Tanoue

JOURNAL OF BIOLOGICAL CHEMISTRY, 282(1) 555-563, Jan, 2007 Peer-reviewed
Regulated overexpression of the A(1)-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function

Hajime Funakoshi, Tung O. Chan, Julie C. Good, Joseph R. Libonati, Jarkko Piuhola, Xiongwen Chen, Scott M. MacDonnell, Ling L. Lee, David E. Herrmann, Jin Zhang …

CIRCULATION, 114(21) 2240-2250, Nov, 2006 Peer-reviewed
The effect of myosin regulatory light chain phosphorylation on the frequency-dependent regulation of cardiac function

Fernando A. L. Dias, Lori A. Walker, Grace M. Arteaga, John S. Walker, Kalpana Vijayan, James R. Pena, Yunbo Ke, Rosalvo T. H. Fogaca, Atsushi Sanbe, Jeffrey Robbins …

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 41(2) 330-339, Aug, 2006 Peer-reviewed
Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2

YN Tallini, M Ohkura, BR Choi, GJ Ji, K Imoto, R Doran, J Lee, P Plan, J Wilson, HB Xin …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(12) 4753-4758, Mar, 2006 Peer-reviewed
Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-beta-crystallin desmin-related cardiomyopathy

A Maloyan, A Sanbe, H Osinska, M Westfall, D Robinson, K Imahashi, E Murphy, J Robbins

CIRCULATION, 112(22) 3451-3461, Nov, 2005 Peer-reviewed
Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy

A Sanbe, H Osinska, C Villa, J Gulick, R Klevitsky, CG Glabe, R Kayed, J Robbins

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(38) 13592-13597, Sep, 2005 Peer-reviewed
Transgenic rabbit model for human troponin I - Based hypertrophic cardiomyopathy

A Sanbe, J James, Tuzcu, V, S Nas, L Martin, J Gulick, H Osinska, S Sakthivel, R Klevitsky, KS Ginsburg …

CIRCULATION, 111(18) 2330-2338, May, 2005 Peer-reviewed
Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction

M Nakayama, XH Yan, RL Price, TK Borg, K Ito, A Sanbe, J Robbins, BH Lorell

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 288(1) H317-H327, Jan, 2005 Peer-reviewed
Physiological growth synergizes with pathological genes in experimental cardiomyopathy

F Syed, A Odley, HS Hahn, EW Brunskill, RA Lynch, Y Marreez, A Sanbe, J Robbins, GW Dorn

CIRCULATION RESEARCH, 95(12) 1200-1206, Dec, 2004 Peer-reviewed
Desmin-related cardiomyopathy in transgenic mice: A cardiac amyloidosis

A Sanbe, H Osinska, JE Saffitz, CG Glabe, R Kayed, A Maloyan, J Robbins

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(27) 10132-10136, Jul, 2004 Peer-reviewed
Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice

XH Yan, RL Price, M Nakayama, K Ito, AJT Schuldt, WJ Manning, A Sanbe, TK Borg, J Robbins, BH Lorell

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 285(5) H2179-H2187, Nov, 2003 Peer-reviewed
Analysis of myosin heavy chain functionality in the heart

M Krenz, A Sanbe, F Bouyer-Dalloz, J Gulick, R Klevitsky, TE Hewett, HE Osinska, JN Lorenz, C Brosseau, A Federico …

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(19) 17466-17474, May, 2003 Peer-reviewed
Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter

A Sanbe, J Gulick, MC Hanks, QR Liang, H Osinska, J Robbins

CIRCULATION RESEARCH, 92(6) 609-616, Apr, 2003 Peer-reviewed
Transgenic rabbits expressing mutant essential light chain do not develop hypertrophic cardiomyopathy

J James, Y Zhang, K Wright, S Witt, E Glascock, H Osinska, R Klevitsky, L Martin, K Yager, A Sanbe …

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 34(7) 873-882, Jul, 2002 Peer-reviewed
Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure

GX Chu, AN Carr, KB Young, JW Lester, A Yatani, A Sanbe, MC Colbert, SM Schwartz, KF Frank, PD Lampe …

CARDIOVASCULAR RESEARCH, 54(1) 105-116, Apr, 2002 Peer-reviewed
Examining the in vivo role of the amino terminus of the essential myosin light chain

A Sanbe, J Gulick, J Fewell, J Robbins

JOURNAL OF BIOLOGICAL CHEMISTRY, 276(35) 32682-32686, Aug, 2001 Peer-reviewed
PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice

QL Yang, TE Hewett, R Klevitsky, A Sanbe, XJ Wang, J Robbins

CARDIOVASCULAR RESEARCH, 51(1) 80-88, Jul, 2001 Peer-reviewed
Three-dimensional MR microscopy of a transgenic mouse model of dilated cardiomyopathy

RW Sze, CB Chan, BJ Dardzinski, S Dunn, A Sanbe, Schmithorst, V, J Robbins, SK Holland, JL Strife

PEDIATRIC RADIOLOGY, 31(2) 55-61, Feb, 2001 Peer-reviewed

Misc.

蛍光検出器を用いたHPLCによるヒト母乳中セロトニンの分析

平舩寛彦, 千葉健史, 前田智司, 富田隆, 三部篤, 武田リカ, 菊池昭彦, 工藤賢三

日本薬学会年会要旨集, 137年会(2) 290-290, Mar, 2017
SGLT1 participates in cardiac remodeling in pressure-overload-induced cardiomyopathy

N. Matsushita, A. Sanbe, H. Koepsell, Y. Morino, E. Taira, M. Hirose

EUROPEAN HEART JOURNAL, 37 524-524, Aug, 2016
セロトニンによる母乳タンパク発現の抑制に関与するPTP1Bの活性化

千葉健史, 前田智司, 木村聡一郎, 上田秀雄, 三部篤, 工藤賢三

日本薬学会年会要旨集, 136年会(3) 155-155, Mar, 2016
Cell Death in Neuromuscular Diseases Foreword

Atsushi Sanbe

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38(8) 1093-1093, Aug, 2015
フルボキサミンによるβ-カゼイン発現抑制メカニズム MCF-12Aを用いた検討

野手立秋, 千葉健史, 前田智司, 木村聡一郎, 森本雍憲, 三部篤, 上田秀雄, 工藤賢三

日本薬学会年会要旨集, 135年会(3) 77-77, Mar, 2015
Modification of cardiac disease by histone deacetylase 6 in pressure-overloaded hypertrophy

A. Sanbe, N. Matsushita, T. Aoyagi, N. Takahashi, Y. Tezuka, H. Nishigori, M. Hirose

EUROPEAN HEART JOURNAL, 35 1009-1009, Sep, 2014
Protein folding disease and ATP-sensitive potassium channels

Atsushi Sanbe, Toshinori Aoyagi, Yu Tezuka

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 46P-46P, 2014
Proapoptotic effect of inorganic pyrophosphatase 1 in hypothyroid embryonic chick cerebellum

Yu Tezuka, Natsumi Herai, Yui Inomata, Keisuke Kagami, Junji Yamauchi, Hideo Nishigori, Atsushi Sanbe

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 179P-179P, 2014
Gene expression patterns of BCL2-related proteins in hypothyroid embryonic chick cerebellum

Yui Inomata, Yu Tezuka, Natsumi Herai, Keisuke Kagami, Hideo Nishigori, Atsushi Sanbe

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 144P-144P, 2014
Cardioprotective effect of nicorandil, a mitochondrial potassium channel opener, via modification of mitochondrial permeability transition pore in myofibrilar myopathy

Toshinori Aoyagi, Yu Yamatoya, Kaori Natsusaka, Yu Tezuka, Atsushi Sanbe

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 134P-134P, 2014
ER STRESS AND CARDIAC ARRHYTHMIAS CAUSED BY alpha B-CRYSTALLIN MUTATION IN MICE

Q. Jiao, A. Sanbe, X. Zhang, J-P Liu, S. Minamisawa

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 40 10-10, Oct, 2013
薬学部による地域住民に対する「くすりの正しい使い方」の啓発活動の実践

手塚優, 松浦誠, 猪俣結衣, 三部篤, 佐塚泰之, 西郡秀夫

日本薬学会年会要旨集, 133年会(4) 223-223, Mar, 2013
Inorganic pyrophosphatase 1 is involved in neurite growth as a protein phosphatase

Atsushi Sanbe, Yu Tezuka, Mizuki Okada, Yuka Tada, Junji Yamauchi, Hideo Nishigori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 121 107P-107P, 2013
岩手県下の公立小学生を対象とした「くすり」に対する意識調査

松浦誠, 手塚優, 三部篤, 西郡秀夫, 佐塚泰之

日本医療薬学会年会講演要旨集, 22nd 411-411, Oct 10, 2012
Nicorandil protects cardiomyocytes against alpha-B-crystallin arg120Gly-induced apoptosis

A. Sanbe, T. Marunouchi, M. Hirose, E. Koizumi, K. Tanonaka, H. Nishigori, A. Tanoue

EUROPEAN HEART JOURNAL, 33 927-927, Aug, 2012
Enhancement of cardiac histone deacetylase 6 (HDAC6) activity protects against cardiac disease in alpha-B-crystallin arg120gly transgenic mouse

A. Sanbe, T. Marunouchi, M. Hirose, S. Aoki, Y. Tada, K. Tanonaka, H. Nishigori, A. Tanoue

EUROPEAN HEART JOURNAL, 33 927-927, Aug, 2012
Nicorandil improved electrical and structural remodeling and prevented ventricular tachyarrhythmias in a mouse model of desmin-related cardiomyopathy

M. Hirose, A. Sanbe, N. Matsushita, E. Taira

EUROPEAN HEART JOURNAL, 33 926-926, Aug, 2012
Involvement of pyrophosphatase1 in neuronal differentiation

Yu Tezuka, Yuka Tada, Hideo Nishigori, Atsushi Sanbe

JOURNAL OF PHARMACOLOGICAL SCIENCES, 118 67P-67P, 2012
Nicorandil, a Mitochondrial ATP-Sensitive Potassium Channel Opener, Protects Cardiomyocytes against alpha-B-Crystallin R120G-Induced Apoptosis

Atsushi Sanbe, Erika Koizumi, Yu Tezuka, Hideo Nishigori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 118 155P-155P, 2012
Overexpression of R120g alpha beta - Crystallin Causes Cardiac Arrhythmias, Reduced Heart Rate Variability, Alteration in the Expression Of Ca2+Handling Proteins and Er Stress in Mice

Qibin Jiao, Atsushi Sanbe, Susumu Minamisawa

CIRCULATION, 124(21), Nov, 2011

Books and Other Publications

薬物治療学 - 薬学テキストシリーズ

三部篤 (Role: Joint author)

朝倉書店, 2020
「薬系薬理学書」

三部篤 (Role: Joint author, 内分泌系薬理、循環器系薬理)

南江堂, 2018
「薬学用語辞典」

三部篤 (Role: Joint author)

日本薬学会編東京化学同人社, 2012
「発生学的研究法：モデル動物マウス」「先天性心疾患を理解するための臨床心臓発生学」

メジカルビュー社 p44-49, 2007

Presentations

HDAC6 and Cardiac disease

Atsushi Sanbe, Yohei Sawa, Nanae Ishida, Masamichi HiroseYohei Sawa, Nanae Ishida, Masamichi Hirose

Aug 27, 2021 Invited
Effect of Bcl-2 associated athanogene (BAG) 3 on cardiac disease in alpha-B crystallin (CryAB) R120G transgenic (TG) mouse.

Sanbe A, Ojima M, Inomata Y, Higashio R, Hirose M

Mar 17, 2020
Effect of chloroquine treatment on cardiac function as well as cardiac atrial natriuretic peptide level in Bcl-2-associated athanogene (BAG) 3 transgenic mice

Sanbe A, Inomata Y, Higashio R, Ishida K, Hirose M

第92回日本薬理学会年会大阪, Mar 16, 2019
Bcl-2 associated athanogene (BAG)3による心筋タンパク質の分解調節

猪俣結衣, 永坂祥太, 宮手一樹, 後藤雄大, 東尾里英子, 石田欣二, 齋野朝幸, 弘瀬雅教, 三部篤

第138回日本薬学会年会金沢, Mar 26, 2018
Functional role of Bcl-2-associated athanogene (BAG) 3 as a regulator of Bak1 protein level in N1E115 cells.

Sanbe A, Inomata Y, Tamada S, Takahashi S, Higashio R, Tezuka Y

18th World Congress of Basic and Clinical Pharmacology, PO4-1-118, Kyoto, 2018
Involvement of secernin 1 in mouse development

Tezuka Yu, Ishigaki K, Otsu H, Takahashi S, Kikuchi Y, Hiramatsu R, Sanbe A

18th World Congress of Basic and Clinical Pharmacology, PO1-13-21, Kyoto, 2018
Bcl-2 associated athanogene 3 enhances alpha-B crystallin protein turnover via activation of autophagy in the heart.

Inomata Y, Miyate K, Goto Y, Higashio R, Hirose M, Sanbe A

European Society of Cardiology Congress. P2625 Barcelona, Spain, 2017
Bcl-2 associated athanogene(BAG)3は心筋タンパク質分解機構の調節因子か？

猪俣結衣, 後藤雄太, 永坂祥大, 宮手一樹, 東尾里英子, 弘瀬雅教, 三部篤

第19回応用薬理シンポジウムシンポジウム１循環障害による疾患の病態研究と創薬、東京, 2017 Invited
SGLT1 participates in cardiac remodeling in pressure-overload-induced cardiomyopathy.

Matsushita N, Sanbe A, Koepsell H, Morino Y, Taira E, Hirose M

European Society of Cardiology Congress. P2645, Roma, Italia, 2016
Bcl-2関連athanogene ３の神経保護作用

猪俣結衣, 玉田さち, 高橋慎太郎, 東尾里英子, 手塚優, 三部篤

第67回日本薬理学会北部会西宮機能系基礎医学研究助成基金受賞演題 A-11、札幌, 2016 Invited
神経筋疾患におけるBCL2関連athanogene 3の機能的役割

猪俣結衣, 日野千鶴, 手塚優, 東尾里英子, 青柳利紀, 三部篤

第135回日本薬学会年会大学院生シンポジウム GS01 循環器疾患に関した新規病態病態制御メカニズムメカニズム-心血管疾患をターゲットとした薬学基礎研究の現状と治療への展望-GS０1-3、神戸, 2015 Invited
心臓疾患におけるヒストン脱アセチル化酵素6の役割

三部篤, 松下尚子, 猪俣結衣, 手塚優, 弘瀬雅教

第1回J-ISCP学術集会国際心血管薬物療法学会日本部会医学・薬学ジョイントシンポジウム(1)―心不全の分子病態と薬物治療、京都, 2015 Invited
Laser-induced intrachoroidal drug delivery system to posterior segment eye disease.

Murata M, Sanbe A, Lee J. W, Murata S

Program Number: 5274 Poster Board Number: C0070, The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) Orlando, FL, 2014
Modification of cardiac disease by histone deacetylase 6 in pressure-overloaded hypertrophy.

Sanbe A, Matsushita N, Aoyagi T, Takahashi N, Tezuka Y, Nishigori H, Hirose M

European Society of Cardiology Congress. P5590 Barcelona, Spain, 2014
Protein Folding Disease and ATP-sensitive Potassium Channels.

Sanbe Atsushi

2014 Invited
ストレスタンパク質と心疾患

三部篤

第134回日本薬学会年会 S14 心疾患と炎症応答、熊本, 2014 Invited
Histon deacetylase (HDAC) 6 in cardiac disease.

Sanbe Atsushi

Symposium 1S07 Cardiac Disease-Regenerative Medicine and Drug Development 第87回日本生化学会年会、京都, 2014 Invited
低分子ストレスタンパク質によって引き起こされる心臓疾患

三部篤

生体機能と創薬誌ポジウム2013 「循環器疾患の新たなターゲットと創薬」、福岡, 2013 Invited
アミロイドと心不全

三部篤

第23回日本循環薬理学会シンポジウム［次世代心不全治療の新機軸］、福岡, 2013 Invited
Nicorandil improved electrical and structural remodeling and prevented ventricular tachyarrthythmias in a mouse model of desmin-related cardiomyopathy.

Hirose, M, Sanbe A, Matsushita N, Taira E

European Society of Cardiology Congress. P5118 Munich, Germany, 2012

Professional Memberships

Research Projects

New therapeutic approach of myofibrillar myopathy by mitochondrial protection

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Sanbe Atsushi
Relationship between SGLT1 and ventricular arrhythmia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

HIROSE MASAMICHI, SANBE Atsushi
Development of new therapeutic strategy for rescuing cardiomyopathy via inhibition of protein aggregation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

SANBE Atsushi
Development of new therapeutic strategy for rescuing cardiomyopathy using small heat shock proteins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

SANBE Atsushi

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