2015年8月
Differential changes in luteinizing hormone secretion after administration of the investigational metastin/kisspeptin analog TAK-683 in goats
ANIMAL REPRODUCTION SCIENCE
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- 巻
- 159
- 号
- 開始ページ
- 87
- 終了ページ
- 93
- 記述言語
- 英語
- 掲載種別
- 速報,短報,研究ノート等(学術雑誌)
- DOI
- 10.1016/j.anireprosci.2015.05.016
- 出版者・発行元
- ELSEVIER SCIENCE BV
This study aimed to evaluate the hormonal and ovarian responses to the administration of a metastin/kisspeptin analog (TAK-683) under the endocrine environments of luteal and follicular phases in goats. Five estrous cycling goats received a prostaglandin F-2 alpha, injection followed by 10 days of progesterone treatment by CIDR. The TAK-683 (35 nmol) was intravenously administered (Hour 0) on 3 days after CIDR insertion (luteal phase condition; LC) and at 12 h after CIDR removal (follicular phase condition; FC). Blood samples were collected at 10 min (-2 to 6 h), 2 h (6-24 h) or 6 h intervals (24-48 h). In the LC, small increases in the basal concentrations of LH were observed after TAK-683 administration from 0 to 6 h, which were associated with an increase in estradiol concentration, followed by a surge-like release of LH with a peak at 12.5 +/- 1.0 h (n = 4) after TAK-683 administration. In the FC, a surge-like release of LH occurred immediately after TAK-683 administration with a peak at 6.0 +/- 3.5 h (n = 5), which was earlier than that in the LC (P < 0.01). The peak concentration of estradiol did not differ between the two conditions, whereas the time interval from TAK-683 treatment to estradiol peak in the LC was longer than that in the FC (12.0 +/- 0.0 compared with 6.0 +/- 4.2 h, P < 0.05). These findings suggest that the timing of surge-like release of LH after TAK-683 administration is associated with blood estradiol concentration at the time of treatment. (C) 2015 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.anireprosci.2015.05.016
- ISSN : 0378-4320
- eISSN : 1873-2232
- PubMed ID : 26051610
- Web of Science ID : WOS:000358808800012