MISC

1994年12月

DECIDUA IS A POSSIBLE SOURCE OF SERUM MOUSE SOLUBLE INTERLEUKIN-6 RECEPTOR (MSIL-6R) - GESTATIONAL PROFILE OF SERUM MSIL-6R CONCENTRATION

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • T MAEDA
  • ,
  • M YAMAGUCHI
  • ,
  • T TAGA
  • ,
  • T KISHIMOTO
  • ,
  • K WADA
  • ,
  • H IKEGAMI
  • ,
  • H KURACHI
  • ,
  • A MIYAKE

205
2
開始ページ
998
終了ページ
1003
記述言語
英語
掲載種別
DOI
10.1006/bbrc.1994.2765
出版者・発行元
ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS

The serum concentration of msIL-6R of 10 weeks old virgin ICR mouse assessed by a RIA was 45.6 +/- 6.6 ng/ml. The serum msIL-6R concentration of the pregnant mouse mated at 10 weeks of age was 41.2 +/- 3.0 ng/ml on day 7 of pregnancy. The serum concentration gradually increased during gestation and reached peak on day 17 of pregnancy (149.1 +/- 13.7 ng/ml). On the third day of the puerperium, the serum msIL-6R concentration of the mother from which the pups had been removed on the day of delivery was decreased to the level of that on day 7 of pregnancy. IL-6R mRNA level in the decidua significantly increased during mid and late gestational stages. msIL-6R was detected in the medium of cultured decidual cells (8.03 +/- 0.28 ng/ml), but not placental cells. Western analysis for msIL-6R using the conditioned medium of the cultured decidual cells resulted in a single band at approximately 45 K. To find out a biological role of msIL-6R during gestation, placental cells were incubated with mIL-6 and msIL-6R, and mPL-I concentration in the medium was assessed by RIA. 2.5 nM mIL-6 did not affect the secretion of mPL-I in placental cells; however, addition of msIL-6R resulted in a significant stimulation of mPL-I secretion. These results suggest that serum msIL-6R, which is likely to be secreted from decidua, may play an important role during gestation. (C) 1994 Academic Press, Inc.

リンク情報
DOI
https://doi.org/10.1006/bbrc.1994.2765
CiNii Articles
http://ci.nii.ac.jp/naid/80008051111
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/7802687
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1994PY70600004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1006/bbrc.1994.2765
  • ISSN : 0006-291X
  • CiNii Articles ID : 80008051111
  • PubMed ID : 7802687
  • Web of Science ID : WOS:A1994PY70600004

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