2016年
Elevated Cardiac Enzymes in Hypertrophic Cardiomyopathy Patients With Heart Failure – A 20-Year Prospective Follow-up Study –
日本循環器學誌
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- ,
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- 巻
- 80
- 号
- 1
- 開始ページ
- 218
- 終了ページ
- 226
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- 一般社団法人 日本循環器学会
<b><i>Background:</i></b>To better understand the evolution of typical hypertrophic cardiomyopathy (HCM) to heart failure (HF), we investigated the relationship between serum biochemical abnormalities and changes in left ventricular (LV) remodeling.<b><i>Methods and Results:</i></b>Seventy-seven HCM patients were followed for 20 years. Creatine kinase (CK), CK-MB, lactate dehydrogenase (LDH), LDH-1, troponin T and myosin light chain-1 (MLC-1) were measured. Abnormal CK-MB elevation was observed in 64% of HCM patients. LDH-1 was not significantly different compared with the control subjects. Troponin T elevation was observed in 3 HCM patients and MLC-1 elevation was not observed. According to median CK-MB, HCM patients were divided into 2 groups: group H (CK-MB ≥2.5%, n=33) and group L (CK-MB <2.5%, n=44). During the follow-up period in group H, LV end-diastolic dimension increased (P<0.0001), fractional shortening decreased (P<0.0004), and left atrial dimension increased (P<0.0001). The markers reflecting LV hypertrophy were significantly decreased. In group L, LV end-diastolic dimension increased (P<0.02) and left atrial dimension increased (P<0.0001). HF was observed in 18 patients in group H and in 4 in group L. There were 14 HF deaths in group H and 2 in group L, and 3 sudden cardiac deaths in group H.<b><i>Conclusions:</i></b>Persistent elevation of cardiac enzymes in HCM patients indicates ongoing myocardial injury, ultimately resulting in death by HF. (<i>Circ J</i> 2016; <b>80:</b> 218–226)
- リンク情報
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- CiNii Articles
- http://ci.nii.ac.jp/naid/130005116989
- ID情報
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- ISSN : 1346-9843
- CiNii Articles ID : 130005116989
- identifiers.cinii_nr_id : 9000312726776