SAKAI Eiko

J-GLOBAL         Last updated: Aug 5, 2019 at 17:07
 
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Name
SAKAI Eiko
Nickname
handle0125668
E-mail
eiko-snagasaki-u.ac.jp
Affiliation
Nagasaki University
Section
Graduate School of Biomedical Sciences, Medical and Dental Sciences
Job title
Assistant Professor
Research funding number
10176612

Research Areas

 
 

Academic & Professional Experience

 
2004
 - 
2007
 Research Associate,Medical and Dental Sciences,Medical and Dental Sciences,Graduate School of Biomedical Sciences,Nagasaki University
 
2007
   
 
 Assistant Professor,Medical and Dental Sciences,Medical and Dental Sciences,Graduate School of Biomedical Sciences,Nagasaki University
 
1995
 - 
2004
 Academic Secretarial Assistant,School of Dentistry,Nagasaki University
 
1984
 - 
1992
 Academic Secretarial Assistant,School of Dentistry,Nagasaki University
 

Education

 
 
 - 
1984
Faculty of Pharmaceutical Science, Nagasaki University
 

Published Papers

 
Calcium phosphate mineralization in bone tissues directly observed in aqueous liquid by atmospheric SEM (ASEM) without staining: microfluidics crystallization chamber and immuno-EM
Sato C, Yamazaki D, Sato M, Takeshima H, Memtily N, Hatano Y, Tsukuba T, Sakai E
Scientific Report      Apr 2019   [Refereed]
KBTBD11, a novel BTB-Kelch protein, is a negative regulator of osteoclastogenesis through controlling Cullin3-mediated ubiquitination of NFATc1.
Narahara S, Sakai E, Kadowaki T, Yamaguchi Y, Narahara H, Okamoto K, Asahina I, Tsukuba T
Scientific Report   9(1) 3523   Mar 2019   [Refereed]
Transcription factor EB (TFEB) influences invasion and migration in oral squamous cell carcinomas.
Sakamoto H, Yamashita K, Okamoto K, Kadowaki T, Sakai E, Umeda M, Tsukuba T
Oral Dis      Jul 2018   [Refereed]
Rutaecarpine attenuate osteoclastogenesis by impairing M-CSF and RANKL-stimulated signaling pathways.
Fukuma Y, Sakai E, Komaki S, Nishishita K, Okamoto K, Tsukuba T
Clin. Exp. Pharmacol Physiol.   45(8) 863-865   Aug 2018   [Refereed]
Dihydroartemisinin represses osteoclastogenesis of bone marrow macrophages through reduced NFATc1 expression and impaired phosphorylation of IκBα.
Komaki S, Sakai E, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T
Biomedical Research   39(4) 169-177   Jan 2018   [Refereed]
Actin binding LIM 1 (abLIM1) negatively controls osteoclastogenesis by regulating cell migration and fusion.
Narahara H, Sakai E, Yamaguchi Y, Narahara S, Iwatake M, Yoshida N, Tsukuba T
J Cell Physiology      Jan 2018   [Refereed]
Rab44, a novel large Rab GTPase, negatively regulates osteoclast differentiation by modulating intracellular calcium levels followed by NFATc1 activation
Yamaguchi Y, Sakai E, Okamoto K, Kajiya H, Okabe K, Naito M, Kadowaki T, Tsukuba T
Cell Mol. Life Sci.   75(1) 33-48   Jan 2018   [Refereed]
The dental resin monomers HEMA and TEGDMA have inhibitory effects on osteoclast differentiation with low cytotoxicity.
Inamitsu H, Okamoto K, Sakai E, Nishishita K, Murata H, Tsukuba T
J Appl Toxicol.   37(7) 817-824   Jul 2017   [Refereed]
Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis.
Sakai E, Morita M, Ohuchi M, Kido MA, Fukuma Y, Nishishita K, Okamoto K, Itoh K, Yamamoto M, Tsukuba T.
FASEB J.   31(9) 4011-4022   Sep 2017   [Refereed]
Yoneshima E, Okamoto K, Sakai E, Nishishita K, Yoshida N, Tsukuba T
J Cell Physiol.   231(6) 1321-1333   Jun 2016   [Refereed]

Misc

 
Satoshi Fukumoto, Tsutomu Iwamoto, Eiko Sakai, Kenji Yuasa, Emiko Fukumoto, Aya Yamada, Tomokazu Hasegawa, Kazuaki Nonaka, Yuzo Kato
Journal of Pharmacological Sciences   100(3) 195-200   2006

Books etc

 
COFFEE IN HEALTH AND DISEASE PREVENTION
Eiko Sakai, Takayuki Tsukuba (Part:Contributor, Chapter 96 Coffee and Bone Metabolism: Kahweol and Osteoclastogenesis)
ACADEMIC PRESS   Mar 2015   ISBN:978-0-12-409517-5

Conference Activities & Talks

 
Up-regulation of heme-oxygenase-1 inhibits RANKL-mediated high-mobility group box 1 release and osteoclastogenesis
2010   
Effect of osteoclast differentiation in cathepsin E-deficiency
2010   
Nrf2 activators inhibit osteoclastogenesis induced by receptor activator of NF-kB ligand
2011   
Receptor activator of NF-kB ligand dependent HO-1 suppression is required for HMGB1 release, caspase-3 activation, and subsequent osteoclastogenesis
2011   
Suppression of RANKL-dependent HO-1 is required for HMGB1 release
2011   
Effects of Kahweol on osteoclast formation and bone resorption
2011   
Effects of tert-Butylhydroquinone on osteoclast formation and bone resorption
2011   
Effects of deltamethrin on osteoclast formation and bone resorption
2011   
Inhibitory effects of fisetin on osteoclastogenesis
2011   
The role of RANKL-dependent suppression of HO-1 on osteoclastogenesis
2011   

Research Grants & Projects

 
Regulation of Osteoclastogenesis mediated by iron-associated molecules
Grant-in-Aid for Scientific Research
Project Year: 2007   
Regulation of Osteoclastogenesis by Glycosphingolipids
Grant-in-Aid for Scientific Research
Project Year: 2003   
Vesicle transport of osteoclast
Grant-in-Aid for Scientific Research
Project Year: 1999 - 2002
Hemagglutination by Adhesin domain of Porphyromonas gingivalis
Grant-in-Aid for Scientific Research
Project Year: 2002   
Regulation of Osteoclastogenesis by Glycosphingolipids
Grant-in-Aid for Scientific Research
Project Year: 2001