Misc.

Jul, 2011

Allogeneic hematopoietic stem cell transplantation for advanced extranodal natural killer/T-cell lymphoma, nasal type

LEUKEMIA & LYMPHOMA
  • Daisuke Ennishi
  • ,
  • Yoshinobu Maeda
  • ,
  • Nobuharu Fujii
  • ,
  • Eisei Kondo
  • ,
  • Katsuji Shinagawa
  • ,
  • Kazuma Ikeda
  • ,
  • Koichi Ichimura
  • ,
  • Tadashi Yoshino
  • ,
  • Mitsune Tanimoto

Volume
52
Number
7
First page
1255
Last page
1261
Language
English
Publishing type
DOI
10.3109/10428194.2011.572322
Publisher
INFORMA HEALTHCARE

The prognosis for patients with advanced or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKL) is extremely poor. Thus, allogeneic stem cell transplantation (allo-HSCT) should be considered for this disease. However, reports of allo-HSCT for ENKL are limited because of the rarity of the disease. Here, we describe the clinical course of 12 cases of advanced and refractory ENKL treated with allo-HSCT, including five cases with cord blood transplant. With a median follow-up of 13 months (range, 1-168 months), seven patients are alive in remission, five have died, and one treatment-related death occurred. All patients with disease progression at transplant died of disease progression, whereas seven of eight patients with a complete or partial response are long-term survivors. Allo-HSCT is a feasible and promising consolidation therapy for advanced and relapsed ENKL. The disease status before allo-HSCT is well associated with general outcome, and thus induction treatment is very important for this disease.

Link information
DOI
https://doi.org/10.3109/10428194.2011.572322
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000291992400017&DestApp=WOS_CPL
ID information
  • DOI : 10.3109/10428194.2011.572322
  • ISSN : 1042-8194
  • Web of Science ID : WOS:000291992400017

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