論文

査読有り
2020年2月

A Promising New Anti-Cancer Strategy: Iron Chelators Targeting CSCs.

Acta medica Okayama
  • Yuehua Chen
  • ,
  • Toshiaki Ohara
  • ,
  • Boyi Xing
  • ,
  • Jiping Qi
  • ,
  • Kazuhiro Noma
  • ,
  • Akihiro Matsukawa

74
1
開始ページ
1
終了ページ
6
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.18926/AMO/57946

Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings.

リンク情報
DOI
https://doi.org/10.18926/AMO/57946
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32099242
ID情報
  • DOI : 10.18926/AMO/57946
  • PubMed ID : 32099242

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