論文

国際誌
2021年3月4日

Nanog is a promising chemo-resistant stemness marker and therapeutic target by iron chelators for esophageal cancer.

International journal of cancer
  • Toru Narusaka
  • ,
  • Toshiaki Ohara
  • ,
  • Kazuhiro Noma
  • ,
  • Noriyuki Nishiwaki
  • ,
  • Yuki Katsura
  • ,
  • Takuya Kato
  • ,
  • Hiroaki Sato
  • ,
  • Yasuko Tomono
  • ,
  • Satoru Kikuchi
  • ,
  • Hiroshi Tazawa
  • ,
  • Yasuhiro Shirakawa
  • ,
  • Akihiro Matsukawa
  • ,
  • Toshiyoshi Fujiwara

149
2
開始ページ
347
終了ページ
357
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/ijc.33544

Esophageal cancer is a disease showing poor prognosis. Although combination chemotherapy using cisplatin and 5-fluorouracil is standard for unresectable esophageal cancer, the response rate is 35%. Cancer stem cells (CSCs) and inflammation are reportedly responsible for the poor prognosis of esophageal cancer. However, comprehensive analyses have not been conducted and proposals for progress remain lacking. Iron is known to be a key factor in the stemness of CSCs. This study focused on the therapeutic potential of iron control using iron chelators for CSCs in esophageal cancer. Among 134 immunohistochemically analyzed cases, Nanog expression was high in 98 cases and low in 36 cases. High Nanog expression correlated with low overall and disease-free survivals. The iron chelators deferasirox (DFX) and SP10 suppressed the proliferation and expression of stemness markers in TE8 and OE33 cells. DFX and SP10 did not induce compensatory interleukin (IL)-6 secretion, although cisplatin did result in high induction. Moreover, BBI608 and SSZ, as other CSC-targeting drugs, could not suppress the expression of stemness markers. Together, Nanog expression appears related to poor prognosis in esophageal cancer patients, and inhibition of stemness and compensatory IL-6 secretion by iron chelators may offer a novel therapeutic strategy for esophageal cancer.

リンク情報
DOI
https://doi.org/10.1002/ijc.33544
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33662150
ID情報
  • DOI : 10.1002/ijc.33544
  • PubMed ID : 33662150

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