論文

国際誌
2019年12月

Rechargeable anti-microbial adhesive formulation containing cetylpyridinium chloride montmorillonite.

Acta biomaterialia
  • Kenya Matsuo
  • ,
  • Kumiko Yoshihara
  • ,
  • Noriyuki Nagaoka
  • ,
  • Yoji Makita
  • ,
  • Hideki Obika
  • ,
  • Takumi Okihara
  • ,
  • Akihiro Matsukawa
  • ,
  • Yasuhiro Yoshida
  • ,
  • Bart Van Meerbeek

100
開始ページ
388
終了ページ
397
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.actbio.2019.09.045

Long-term anti-bacterial effect is a desired ability of any dental material in combating tooth caries as one of the most common and widespread persistent diseases today. Among several cationic quaternary ammonium compounds with antiseptic properties, cetylpyridinium chloride (CPC) is often used in mouthrinses and toothpastes. In this study, we incorporated CPC in a soft phyllosilicate mineral (clay), referred to as montmorillonite (Mont), to enable gradual CPC release with rechargeability. Besides measuring CPC release and recharge, we examined the anti-bacterial effect, cytotoxicity and bonding effectiveness of five experimental adhesive formulations, prepared by adding 1 and 3 wt% CPC_Mont, 3 wt% Mont (without CPC), and 1 and 3 wt% CPC (without Mont) to the commercial adhesive Clearfil S3 Bond ND Quick ('C-S3B'; Kuraray Noritake). Strong inhibition of Streptococcus mutans biofilm formation by CPC_Mont adhesives was confirmed by optical density and SEM. CPC release from CPC_Mont adhesives was higher and lasted longer than from CPC adhesives, while CPC_Mont adhesives could also be recharged with CPC upon immersion in 2 wt% CPC. In conclusion, CPC_Mont technology rendered adhesives anti-bacterial properties with recharge ability, this without reducing its bonding potential, neither increasing its cytotoxicity. STATEMENT OF SIGNIFICANCE: Dental caries is one of the most prevalent chronic diseases in the population worldwide and is the major cause of tooth loss. In this study, we developed cetylpyridinium chloride (CPC) loaded montmorillonite (CPC-Mont) with a long-term antibacterial efficacy to prevent caries. CPC is an antibacterial agent approved by FDA, used as an OTC drug and contained in oral hygiene aids. CPC-Mont was incorporated in a dental adhesive to gradually release CPC. CPC_Mont technology rendered adhesives anti-bacterial properties with rechargeability, this without reducing its bonding potential, neither increasing its cytotoxicity.

リンク情報
DOI
https://doi.org/10.1016/j.actbio.2019.09.045
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31568874
ID情報
  • DOI : 10.1016/j.actbio.2019.09.045
  • PubMed ID : 31568874

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