Kentaro Otani

Profile Information

Affiliation: Laboratory chief, Department of Molecular Pharmacology, National Cerebral and Cardiovascular Center

Degree: 修士(保健学)(Mar, 2003, 大阪大学)
博士(保健学)(Mar, 2006, 大阪大学)

Researcher number: 50470191
J-GLOBAL ID: 200901048281685350
researchmap Member ID: 5000095767

Research Interests

Research Areas

Life sciences / Medical systems /

Research History

May, 2023 - Present

研究室長, 分子薬理部, 国立循環器病研究センター研究所
May, 2022 - Present

Laboratory chief, Center for Regenerative Medicine, National Cerebral and Cardiovascular Center, Research Institute
Apr, 2011 - Present

国立循環器病研究センター研究所研究員
Apr, 2008 - Mar, 2011

国立循環器病研究センター研究所流動研究員
Apr, 2006 - Mar, 2008

ヒューマンサイエンス振興財団リサーチレジデント

Education

- Mar, 2006

Graduate School of Medicine, Osaka University
- Mar, 2003

Graduate School of Medicine, Osaka University
- Mar, 2001

Faculty of Medicine, Osaka University

Awards

Apr, 2017

第3回日本心筋症研究会 Young Investigator Award 優秀賞, 日本心筋症研究会

大谷健太郎
Oct, 2015

第51回高血圧関連疾患モデル学会ベストポスター賞, 高血圧関連疾患モデル学会

大谷健太郎
Feb, 2014

第43回日本心脈管作動物質学会研究奨励賞（YIA）, 日本心脈管作動物質学会

大谷健太郎
Nov, 2013

第17回日本心血管内分泌代謝学会若手研究奨励賞（YIA）, 日本心血管内分泌代謝学会

大谷健太郎
2012

平成24年度海外学会発表優秀論文賞, 日本心エコー図学会

大谷健太郎
Dec, 2010

第12回国際造影超音波シンポジウム Best Presentation Award

大谷健太郎
Dec, 2004

第6回国際造影超音波シンポジウム優秀論文賞

大谷健太郎
2004

平成16年度海外学会発表優秀論文賞, 日本心エコー図学会

大谷健太郎

Papers

Molecular Mechanism of Blood Pressure Regulation through the Atrial Natriuretic Peptide.

Takeshi Tokudome, Kentaro Otani

Biology, 11(9), Sep 14, 2022
Endothelial natriuretic peptide receptor 1 play crucial role for acute and chronic blood pressure regulation by atrial natriuretic peptide

Takeshi Tokudome, Kentaro Otani, Yuanjie Mao, Lars Jørn Jensen, Yuji Arai, Takahiro Miyazaki, Takashi Sonobe, James T. Pearson, Tsukasa Osaki, Naoto Minamino …

Hypertension, 79(7) 1409-1422, 2022 Peer-reviewedLead author
【ナトリウム利尿ペプチドに関する話題】妊娠中および産褥期における心臓ナトリウム利尿ペプチドの生理的意義の解明

大谷健太郎, 神谷千津子, 徳留健

循環器内科, 89(4) 386-394, Apr, 2021
Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart.

Kentaro Otani, Takeshi Tokudome, Chizuko A Kamiya, Yuanjie Mao, Hirohito Nishimura, Takeshi Hasegawa, Yuji Arai, Mari Kaneko, Go Shioi, Junji Ishida …

Circulation, 141(7) 571-588, Feb 18, 2020 Peer-reviewed
Suppression of Lysophosphatidylcholine-Induced Human Aortic Smooth Muscle Cell Calcification by Protein Kinase A Inhibition.

Riki Toita, Daisuke Asai, Kentaro Otani, Takahito Kawano, Masaharu Murata, Jeong-Hun Kang

Lipids, 54(8) 465-470, Aug, 2019 Peer-reviewed
Surface Modification with Lactadherin Augments the Attachment of Sonazoid Microbubbles to Glycoprotein IIb/IIIa.

Kentaro Otani, Atsunori Kamiya, Takahiro Miyazaki, Ayumi Koga, Ayako Inatomi, Mariko Harada-Shiba

Ultrasound in medicine & biology, 45(6) 1455-1465, Jun, 2019 Peer-reviewed
Corrigendum to “Protein kinase A (PKA) inhibition reduces human aortic smooth muscle cell calcification stimulated by inflammatory response and inorganic phosphate” (Life Sciences (2018) 209 (466–471), (S0024320518305125) (10.1016/j.lfs.2018.08.051))

Riki Toita, Kentaro Otani, Takahito Kawano, Satoshi Fujita, Masaharu Murata, Jeong Hun Kang

Life Sciences, 224 138, May 1, 2019
Ghrelin and the heart.

Takeshi Tokudome, Kentaro Otani, Mikiya Miyazato, Kenji Kangawa

Peptides, 111 42-46, Jan, 2019 Peer-reviewed
Protein kinase A (PKA) inhibition reduces human aortic smooth muscle cell calcification stimulated by inflammatory response and inorganic phosphate.

Riki Toita, Kentaro Otani, Takahito Kawano, Satoshi Fujita, Masaharu Murata, Jeong-Hun Kang

Life sciences, 209 466-471, Sep 15, 2018 Peer-reviewed
妊娠高血圧〜新分類・治療法から病態研究まで〜周産期心筋症におけるナトリウム利尿ペプチド系の病態生理学的意義

徳留健, 大谷健太郎, 神谷千津子, 池田智明

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集, 7回 141-141, May, 2018
Simplified Preparation of αvβ3 Integrin-Targeted Microbubbles Based on a Clinically Available Ultrasound Contrast Agent: Validation in a Tumor-Bearing Mouse Model.

Kentaro Otani, Hirohito Nishimura, Atsunori Kamiya, Mariko Harada-Shiba

Ultrasound in medicine & biology, 44(5) 1063-1073, May, 2018 Peer-reviewed
A New Secretory Peptide of Natriuretic Peptide Family, Osteocrin, Suppresses the Progression of Congestive Heart Failure After Myocardial Infarction.

Takahiro Miyazaki, Kentaro Otani, Ayano Chiba, Hirohito Nishimura, Takeshi Tokudome, Haruko Takano-Watanabe, Ayaka Matsuo, Hiroyuki Ishikawa, Keiko Shimamoto, Hajime Fukui …

Circulation research, 122(5) 742-751, Mar 2, 2018 Peer-reviewed
周産期心筋症患者ゲノムにおけるナトリウム利尿ペプチド関連遺伝子の多型性解析

大谷健太郎, 徳留健, 神谷千津子, 西村博仁, 岸本一郎, 寒川賢治

日本内分泌学会雑誌, 92(3) 896-896, Jan, 2017
Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity.

Makiko Ohshima, Jacques-Olivier Coq, Kentaro Otani, Yorito Hattori, Yuko Ogawa, Yoshiaki Sato, Mariko Harada-Shiba, Masafumi Ihara, Masahiro Tsuji

Scientific reports, 6 39377-39377, Dec 20, 2016 Peer-reviewed
Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ Development.

Takeshi Tokudome, Ichiro Kishimoto, Takayuki Shindo, Hayato Kawakami, Teruhide Koyama, Kentaro Otani, Hirohito Nishimura, Mikiya Miyazato, Masakazu Kohno, Kazuwa Nakao …

Endocrinology, 157(1) 358-67, Jan, 2016 Peer-reviewed
Endogenous ghrelin attenuates pressure overload-induced cardiac hypertrophy via a cholinergic anti-inflammatory pathway.

Yuanjie Mao, Takeshi Tokudome, Ichiro Kishimoto, Kentaro Otani, Hirohito Nishimura, Osamu Yamaguchi, Kinya Otsu, Mikiya Miyazato, Kenji Kangawa

Hypertension (Dallas, Tex. : 1979), 65(6) 1238-44, Jun, 2015 Peer-reviewed
Aggravated renal tubular damage and interstitial fibrosis in mice lacking guanylyl cyclase-A (GC-A), a receptor for atrial and B-type natriuretic peptides

Fumiki Yoshihara, Takeshi Tokudome, Ichiro Kishimoto, Kentaro Otani, Atsunori Kuwabara, Takeshi Horio, Yuhei Kawano, Kenji Kangawa

CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19(2) 197-207, Apr, 2015 Peer-reviewed
One dose of oral hexarelin protects chronic cardiac function after myocardial infarction

Yuanjie Mao, Takeshi Tokudome, Ichiro Kishimoto, Kentaro Otani, Mikiya Miyazato, Kenji Kangawa

PEPTIDES, 56 156-162, Jun, 2014 Peer-reviewed
内因性心臓ナトリウム利尿ペプチド系による授乳期心保護作用のメカニズム解析

大谷健太郎, 徳留健, 岸本一郎, 山原研一, 中尾一和, 寒川賢治

日本内分泌学会雑誌, 90(1) 279-279, Apr, 2014
Effects of intravenous administration of umbilical cord blood CD34(+) cells in a mouse model of neonatal stroke.

Tsuji M, Taguchi A, Ohshima M, Kasahara Y, Sato Y, Tsuda H, Otani K, Yamahara K, Ihara M, Harada-Shiba M …

263 148-158, Mar, 2014 Peer-reviewed

Misc.

モデル動物を用いた周産期心筋症発症機序の解明

大谷健太郎, 徳留健, 神谷千津子, 池田智明

日本心臓病学会学術集会抄録, 67回 SS-4, Sep, 2019
Ultrasound Molecular Imaging of Angiogenesis Using alphavbeta3 Integrin-targeted Bubbles Based on a Clinically Available Ultrasound Contrast Agent

Kentaro Otani, Hirohito Nishimura, Atsunori Kamiya, Mariko Harada-Shiba

CIRCULATION, 136, Nov, 2017
Systemic Administration of Allogenic Fetal Membrane-derived MSC Ameliorates Experimental Autoimmune Myocarditis via Suppression of Th1/Th17 Immunity

Kenichi Yamahara, Makiko Ohshima, Ken Ishikane, Kazuhiko Harada, Hidetoshi Tsuda, Kentaro Otani, Makoto Kodama, Kenji Kangawa, Tomoaki Ikeda

CIRCULATION, 126(21), Nov, 2012
妊産婦と循環器疾患心血管疾患合併妊娠、周産期(産褥)心筋症のup to date

池田智明, 神谷千津子, 大谷健太郎, 徳留健, 岸本一郎

日本心臓病学会誌, 5(Suppl.I) 198-198, Aug, 2010
Transplanted allogenic fetal membrane-derived mesenchymal stem cell contributes to renal repair via paracrine actions in experimental glomerulonephritis

Hidetoshi Tsuda, Kenichi Yamahara, Shin Ishikane, Kentaro Otani, Masaharu Sada, Masaru Horio, Yoshitaka Isaka, Shiro Takahara, Kenji Kangawa, Tomoaki Ikeda

ENDOCRINE JOURNAL, 57 S616-S616, Mar, 2010
Development of Antibody-Carrying Microbubbles Based on Clinically Available Ultrasound Contrast Agent for Targeted Molecular Imaging: A Preliminary Chemical Study.

Mol Imaging Biol, 2010
Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles

Kentaro Otani, Kenichi Yamahara, Shunsuke Ohnishi, Hiroaki Obata, Soichiro Kitamura, Noritoshi Nagaya

JOURNAL OF CONTROLLED RELEASE, 133(2) 146-153, Jan, 2009
Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles

Kentaro Otani, Kenichi Yamahara, Shunsuke Ohnishi, Hiroaki Obata, Soichiro Kitamura, Noritoshi Nagaya

JOURNAL OF CONTROLLED RELEASE, 133(2) 146-153, Jan, 2009
CONTRAST SONOGRAPHY ENABLES NONINVASIVE AND QUANTITATIVE ASSESSMENT OF NEOVASCULARIZATION AFTER STEM CELL TRANSPLANTATION

Kentaro Otani, Shunsuke Ohnishi, Hiroaki Obata, Osamu Ishida, Soichiro Kitamura, Noritoshi Nagaya

ULTRASOUND IN MEDICINE AND BIOLOGY, 34(12) 1893-1900, Dec, 2008
CONTRAST SONOGRAPHY ENABLES NONINVASIVE AND QUANTITATIVE ASSESSMENT OF NEOVASCULARIZATION AFTER STEM CELL TRANSPLANTATION

Kentaro Otani, Shunsuke Ohnishi, Hiroaki Obata, Osamu Ishida, Soichiro Kitamura, Noritoshi Nagaya

ULTRASOUND IN MEDICINE AND BIOLOGY, 34(12) 1893-1900, Dec, 2008
Corrected quantification method to determine myocardial blood flow using real-time myocardial contrast echocardiography

Kentaro Otani, Kasurni Masuda, Toshihiko Asanuma, Fuminobu Ishikura, Shintaro Beppu

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 19(8) 973-981, Aug, 2006
Corrected quantification method to determine myocardial blood flow using real-time myocardial contrast echocardiography.

Kentaro Otani, Kasumi Masuda, Toshihiko Asanuma, Fuminobu Ishikura, Shintaro Beppu

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 19(8) 973-81, Aug, 2006 Peer-reviewed
PJ-167 Characteristic of Myocardial Perfusion in Diffuse Transumural Myocardial Infarction : Assessment by Myocardial Contrast Echocardiography(Echo/Doppler-12 (I) PJ28,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Uranishi Ayumi, Taniguchi Asuka, Masuda kasumi, Otani Kentaro, Uehara Takashi, Ishikura Fuminobu, Ishikura Fuminobu, Beppu Shintaro

Circulation journal : official journal of the Japanese Circulation Society, 70 531-531, Mar 1, 2006
Destruction of microbubbles in the ventricular cavities affects the quantitative assessment of myocardial perfusion during real-time myocardial contrast echocardiography

OTANI K

J Echocardiogr, 4(3) 78-83, 2006
An Ultimate Method for Quantitative Assessment of Myocardial Perfusion in Real-Time Myocardial Contrast Echocardiography(Echo/Doppler 16 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Otani Kentaro, Hongawa Ayako, Masuda Kasumi, Asanuma Toshihiko, Ishikura Fuminobu, Beppu Shintaro

Circulation journal : official journal of the Japanese Circulation Society, 69 333-333, Mar 1, 2005
Complete Bubble Destruction is Essential for Quantitative Assessment From the Replenishment Curve in Real-time Myocardial Contrast Echocardiography

Kentaro Otani, Kasumi Masuda, Toshihiko Asanuma, Ayako Hongawa, Miyako Takaoka, Takashi Uehara, Fuminobu Ishikura, Shintaro Beppu

Journal of Echocardiography, 3(1) 21-26, 2005
Adenosine triphosphate stress myocardial contrast echocardiography detects coronary artery stenosis with greater sensitivity than wall-motion abnormality measurements

K Otani, T Toshida, A Iwata, T Asanuma, F Ishikura, S Beppu

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 17(12) 1275-1280, Dec, 2004
Adenosine triphosphate stress myocardial contrast echocardiography detects coronary artery stenosis with greater sensitivity than wall-motion abnormality measurements.

Kentaro Otani, Tsutomu Toshida, Akiko Iwata, Toshihiko Asanuma, Fuminobu Ishikura, Shintaro Beppu

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 17(12) 1275-80, Dec, 2004 Peer-reviewed
FRS-002 Measurement of Compartment Blood Volume in The Myocardium : Myocardial Contrast Echocardiographic Study(Ultrasound Medicine in Cardiology (I) : FRS1)(Featured Research Session (English))

Miki Ayako, Azakami Ryoko, Uehara Takashi, Katsuta Tomoko, Kita Makiko, Hongawa Ayako, Okuda Kohei, Hirano Takashiro, Fujihara Tomoko, Masuda Kasumi …

Circulation journal : official journal of the Japanese Circulation Society, 68 90-90, Mar 1, 2004
OJ-271 Hypertriglyceridemia decreases coronary flow reserve and increases myocardial blood volume : Real-time myocardial contrast echocardiographic study(Echo/Doppler 10 (I) : OJ32)(Oral Presentation (Japanese))

Masuda Kasumi, Azakami Ryoko, Uehara Takashi, Okuda Kohei, Hirano Takashiro, Fujihara Tomoko, Miki Ayako, Otani Kentaro, Asanuma Toshihiko, Ishikura Fuminobu …

Circulation journal : official journal of the Japanese Circulation Society, 68 295-296, Mar 1, 2004

Professional Memberships

Research Projects

周産期心筋症の病態－遺伝要因・心筋炎症・血管障害－解明研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

神谷千津子, 徳留健, 大谷健太郎, 吉松淳, 高橋篤
Development of Anti-inflammation Regenerative Therapy for Acute Myocarditis Using Amnion-Derived Stromal Cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
心臓リモデリングにおける交感神経非依存的な新規の脳－心臓連環機構の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

大谷健太郎
Biomarker study for early diagnosis of peripartum cardiomyopathy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Kamiya Chizuko
Development of novel therapy for postpartum cardiomyopathy based on the comprehensive analysis of animal model and clinical gene sample

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

OTANI KENTARO
Development of innovative therapy of metabolic syndrome applying physiological effects of cardiac hormones

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Tokudome Takeshi
Mechanisms how low birthweight caused by intrauterine hypoperfusion leads to neurological problems

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Tsuji Masahiro
Biomarker research of peripartum cardiomyopathy with hypertensive disorders in pregnancy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Kamiya Chizuko, Nakaoka Yoshikazu, Ueda Hatsue, Ogo Keiko, Ishizu Tomoko, Inoue Noriko, Ueno Naoko, Eguchi Kazuo, Oguchi Hidenori, Kaji Takashi, Katsuragi Shinji, Kawamatsu Naoto, Kido Saki, Koitabashi Toshimi, Koyama Masayuki, Suzuki Kazunao, Daimon Atsushi, Nishiguchi Tomizou, Fukushima Yasue, Mito Asako, Wada Yoshinao
Molecular Imaging of Transplanted Stem Cells Derived from Original NIS Transgenic Mouse

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

INUBUSHI Masayuki, OTANI Kentaro, ZENIYA Tsutomu, TSUKAMOTO Satoshi, TAKEUCHI Yasuto, XU Hua, SAITO Yoko
Development of a novel therapy for peripartum cardiomyopathy using natriuretic peptides

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

OTANI KENTARO, KAMIYA CHIZUKO, NISHIMURA HIROHITO
Development of method for the systemic separation of fetal membrane-derived MSCs to establish the cell-specific transplantation therapy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

IKEDA TOMOAKI, YAMAHARA Kenichi, OTANI Kentaro, INUBUSHI Masayuki
Molecular Imaging Research for Forefront of Cardiovascular Medicine

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2014

INUBUSHI Masayuki, SAGA Tsuneo, KOIZUMI Mitsuru, JIN Yong-nan, YAMAHARA Ken-ichi, LI Xiao-kang, OTANI Kentaro, HATAYAMA Naoyuki
Development of molecular-targeted bubbles based on clinically available ultrasound contrast agent

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2013

OTANI Kentaro
Development of ultrasound molecular imaging with targeted-microbubbles

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2009 - 2010

OTANI Kentaro

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