IWATA Makoto

J-GLOBAL         Last updated: Aug 6, 2019 at 16:36
 
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Name
IWATA Makoto
Affiliation
Waseda University
Section
Research Organization for Nano & Life Innovation
Job title
Guest Professor
Degree
Ph.D.(The University of Tokyo)
Research funding number
50160122

Profile

Education/Training:
1975 Batchelor of Science (Chemistry), The University of Tokyo, Faculty of Science
1980 Ph.D. (Immunology & Biochemistry), The University of Tokyo, Graduate School of
Pharmaceutical Sciences

Professional Career:
1980 Postdoctoral Fellow (Immunology), NIAID, NIH, Washington DC, USA
1981 Postdoctoral Fellow (Immunology), Subdepartment of Immunology, The Johns Hopkins
University School of Medicine, Baltimore, MA, USA
1983 Lecturer (Assistant Professor) (Microbiology & Immunology), University of Tsukuba School
of Medicine, Tsukuba, Ibaraki
Then, after the second stay in The Johns Hopkins University as a faculty member;
1989 Senior Researcher, Mitsubishi Kasei(Kagaku) Institute of Life Sciences, Machida, Tokyo
1999 Department Director, Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo
2005 Professor (Immunology), Kagawa School of Pharmaceutical Sciences, Tokushima Bunri
University, Sanuki, Kagawa (The names of the Laboratory and the Department have been
changed from "Biodefense Research" and "Faculty of Pharmaceutical Sciences at Kagawa
Campus", respectively, since 2012.)
2017 Visiting Senior Researcher/Guest Professor, Research Organization for Nano & Life
Innovation, Waseda University, Center for Advanced Biomedical Sciences (TWIns),
Shinjuku, Tokyo

Awards:
2013 Japanese Association for Food Immunology Award

Research Areas

 
 

Education

 
 
 - 
1980
Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
 
 
 - 
1975
Department of Chemistry, Faculty of Science, The University of Tokyo
 

Committee Memberships

 
Oct 2008
 - 
Today
The Japanese Society for Immunology  Councilor
 
Feb 2013
 - 
Jan 2018
Pharmaceutical Society of Japan  Representative
 

Awards & Honors

 
Oct 2013
Japanese Association for Food Immunology Award
 
2013
The Uehara Memorial Foundation Research Grant
 
2007
The Naito Foundation Research Grant
 
2008
The Uehara Memorial Foundation Research Grant
 
2010
The Danone Institute of Japan Foundation Research Grant
 

Misc

 
Aya Yokota-Nakatsuma, Yoshiharu Ohoka, Yoshiharu Ohoka, Hajime Takeuchi, Hajime Takeuchi, Si Young Song, Si Young Song, Makoto Iwata
Scientific Reports   6    Nov 2016   [Refereed]
© The Author(s) 2016. Retinoic acid (RA)-producing CD103+mature dendritic cells (DCs) in mesenteric lymph nodes (MLNs) play crucial roles in gut immunity. GM-CSF and RA contribute to the expression of the RA-producing enzyme ALDH1A2. However, addi...
Isao Okayasu, Kiyomi Hana, Noriko Nemoto, Tsutomu Yoshida, Makoto Saegusa, Aya Yokota-Nakatsuma, Si Young Song, Makoto Iwata
BioMed Research International   2016    Jan 2016   [Refereed]
© 2016 Isao Okayasu et al. Vitamin A is essential to mucosal immunity and cell differentiation. The fact that lack of it might involve chronic inflammation and increased risk of cancer has been reported. Little is known about the mechanism of vita...
J. Rodrigo Mora, Makoto Iwata
The Retinoids: Biology, Biochemistry, and Disease   465-483   Jun 2015   [Invited]
© 2015 John Wiley & Sons, Inc. This chapter summarizes the current understanding of the critical role of retinoic acid (RA) in the development and regulation of the immune system with a special emphasis on the gastrointestinal mucosa. Immune tol...
Yoshiharu Ohoka, Aya Yokota-Nakatsuma, Aya Yokota-Nakatsuma, Naoko Maeda, Naoko Maeda, Hajime Takeuchi, Hajime Takeuchi, Makoto Iwata
PLoS ONE   9(5) e96512   May 2014   [Refereed]
Retinoic acid (RA)-producing dendritic cells (DCs) play critical roles in gut immunity. Retinal dehydrogenase 2 (RALDH2) encoded by Aldh1a2 is a key enzyme for generating RA in DCs. Granulocyte-macrophage colony-stimulating factor (GM-CSF) potentl...
A. Yokota-Nakatsuma, H. Takeuchi, H. Takeuchi, Y. Ohoka, Y. Ohoka, C. Kato, S. Y. Song, S. Y. Song, T. Hoshino, H. Yagita, T. Ohteki, T. Ohteki, M. Iwata
Mucosal Immunology   7(4) 786-801   Jul 2014   [Refereed]
The vitamin A (VA) metabolite retinoic acid (RA) affects the properties of T cells and dendritic cells (DCs). In VA-deficient mice, we observed that mesenteric lymph node (MLN)-DCs induce a distinct inflammatory T helper type 2 (Th2)-cell subset t...
Takeuchi H, Yokota-Nakatsuma A, Ohoka Y, Kagechika H, Kato C, Song SY, Iwata M.
J Immunol   191(7) 3725-3733   Oct 2013   [Refereed]
Retinoic acid (RA) enhances TGF-β-dependent differentiation of Foxp3+inducible regulatory T cells (iTregs) and inhibits Th17 differentiation by binding to the RA receptor (RAR)/retinoid X receptor (RXR) heterodimer. The major physiologic RA, all-t...
Sato T, Kitawaki T, Fujita H, Iwata M, Iyoda T, Inaba K, Ohteki T, Hasegawa S, Kawada K, Sakai Y, Ikeuchi H, Nakase H, Niwa A, Takaori-Kondo A, Kadowaki N
J Immunol   191(6) 3152-3160   Sep 2013   [Refereed]
All-trans-retinoic acid (RA) plays a critical role in maintaining immune homeostasis. Mouse intestinal CD103+ dendritic cells (DCs) produce a high level of RA by highly expressing retinal dehydrogenase (RALDH)2, an enzyme that converts retinal to ...
Makoto Iwata, Aya Yokota, Aya Yokota
Vitamins and Hormones   86 127-152   Mar 2011   [Invited]
Subpopulations of dendritic cells (DCs) in the small intestine and its related lymphoid organs can produce retinoic acid (RA) from vitamin A (retinol). Through the RA production, these DCs play a pivotal role in imprinting lymphocytes with gut-hom...
Hiroyuki Tezuka, Yukiko Abe, Jumpei Asano, Jumpei Asano, Taku Sato, Taku Sato, Jiajia Liu, Makoto Iwata, Makoto Iwata, Toshiaki Ohteki, Toshiaki Ohteki
Immunity   34(2) 247-257   Feb 2011   [Refereed]
Although both conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) are present in the gut-associated lymphoid tissues (GALT), the roles of pDCs in the gut remain largely unknown. Here we show a critical role for pDCs in T ce...
Takeuchi H, Yokota A, Ohoka Y, Iwata M.
PLoS ONE   6(1)    Feb 2011   [Refereed]
Background: The vitamin A metabolite, retinoic acid (RA), plays important roles in the regulation of lymphocyte properties. Dendritic cells in gut-related lymphoid organs can produce RA, thereby imprinting gut-homing specificity on T cells and enh...
Yoshiharu Ohoka, Aya Yokota, Aya Yokota, Hajime Takeuchi, Hajime Takeuchi, Naoko Maeda, Makoto Iwata
Journal of Immunology   186(2) 733-744   Jan 2011   [Refereed]
Retinoic acid (RA) imprints gut-homing specificity on T cells upon activation by inducing the expression of chemokine receptor CCR9 and integrin α4β7. CCR9 expression seemed to be more highly dependent on RA than was the α4β7 expression, but its m...
Takeuchi H, Yokota A, Ohoka Y, Kagechika H, Kato C, Song SY, Iwata M.
J Immunol   185(9) 5289-5299   Nov 2010   [Refereed]
The active vitamin A metabolite retinoic acid (RA) imprints gut-homing specificity on lymphocytes upon activation by inducing the expression of α4β7 integrin and CCR9. RA receptor (RAR) activation is essential for their expression, whereas retinoi...
Sun Young Chang, Hye Ran Cha, Jae Hoon Chang, Hyun Jeong Ko, Hyungjun Yang, Bernard Malissen, Makoto Iwata, Mi Na Kweon
Gastroenterology   138    Jan 2010   [Refereed]
Background & Aims: Retinoic acid (RA) is a crucial factor for maintaining homeostasis in the gut, including lymphocyte homing, immunoglobulin (Ig) A production, and T regulatory cells (Treg) and T helper cell 17 (TH17) generation. Until now, most ...
Yokota, A., Takeuchi, H., Maeda, N., Ohoka, Y., Kato, C., Song, S.-Y., and Iwata, M.
International Immunology   21(4) 361-377   Apr 2009   [Refereed]
Retinoic acid (RA) produced by intestinal dendritic cells (DCs) imprints gut-homing specificity on lymphocytes and enhances Foxp3regulatory T-cell differentiation. The expression of aldehyde dehydrogenase (ALDH) 1A in these DCs is essential for th...
Makoto Iwata
Seminars in Immunology   21(1) 8-13   Feb 2009   [Invited]
Vitamin A deficiency causes a marked reduction in the number of T and B cells in the small intestinal tissues. The vitamin A metabolite retinoic acid imprints lymphocytes with gut-homing specificity upon antigenic stimulation. In the small intesti...
Makoto Iwata (Guest Editor)
Seminars in Immunology   21 1   Feb 2009   [Invited]
J. Rodrigo Mora, Makoto Iwata, Ulrich H. Von Andrian
Nature Reviews Immunology   8(9) 685-698   Sep 2008   [Refereed][Invited]
Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effec...
Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira, Toshiaki Ohteki
Nature   448 929-933   Aug 2007   [Refereed]
Immunoglobulin-A has an irreplaceable role in the mucosal defence against infectious microbes. In human and mouse, IgA-producing plasma cells comprise ∼20% of total plasma cells of peripheral lymphoid tissues, whereas more than 80% of plasma cells...
J. Rodrigo Mora, Makoto Iwata, Bertus Eksteen, Si Young Song, Tobias Junt, Balimkiz Senman, Kevin L. Otipoby, Aya Yokota, Hajime Takeuchi, Paola Ricciardi-Castagnoli, Klaus Rajewsky, David H. Adams, Ulrich H. Von Andrian
Science   314(5802) 1157-1160   Nov 2006   [Refereed]
Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell-independent expression of IgA ...
Makoto Iwata
Seikagaku. The Journal of Japanese Biochemical Society.   78 738-748   Aug 2006   [Invited]
Makoto Iwata
Current Immunology Reviews   2 345-355   Jan 2006   [Invited]
Vitamin A supplementation significantly reduces infant mortality in developing countries, largely by reducing persistent diarrhea that is often aggravated by malnutrition. Vitamin A contributes to maintaining the integrity of mucosal epithelia and...
Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY.
Immunity   21(4) 527-538   2004   [Refereed]
Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, and Song SY
Immunol Lett   94 135-139   2004   [Refereed]
Tosa N, Murakami M, Jia WY, Yokoyama M, Masunaga T, Iwabuchi C, Inobe M, Miyazaki T, Onoe K, Iwata M, and Uede T
Int Immunol   15(6) 741-749   2003   [Refereed]
Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids.
Hideki Miyaura and Makoto Iwata
J Immunol   168 1087-1094   2002   [Refereed]
Adachi S, Kuwata T, Miyaike M, and Iwata M
Biochem Biophys Res Commun   288 1188-1193   2001   [Refereed]
Adachi S, Amasaki Y, Miyatake S, Arai N, Iwata M
J Biol Chem   275(19) 14708-14716   2000   [Refereed]
Asada A, Zhao Y, Komano H, Kuwata T, Mukai M, Fujita K, Tozawa Y, Iseki R, Tian H, Sato K, Motegi Y, Suzuki R, Yokoyama M, and Iwata M
Immunology   101 309-315   2000   [Refereed]
Kuwata T, Asada A, Ohoka Y, Mukai M, Miyaike M, and Iwata M
Biochem Biophys Res Commun   247 242-248   1998   [Refereed]
Asada A, Zhao Y, Kondo T, and Iwata M
J Biol Chem   273 28392-28398   1998   [Refereed]
Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, M. Iwata, Shimizu J, and Sakaguchi S
Int Immunol   10(12) 1969-1980   Aug 1998   [Refereed]
Regulation of thymocyte lineage commitment by the level of classical protein kinase C activity
Ohoka Y, Kuwata T, Asada A, Zhao Y, Mukai M, and Iwata M
J Immunol   158 5707-5716   1997   [Refereed]
CD4+ T cells, positive selection, and surveillance of autoantibody production
Shinohara N, Komano H, Lee MH, Tachibana M, and Iwata M
Immunologist   5 121-126   1997   [Refereed]
Regulation of T cell apoptosis via T cell receptors and steroid receptors
Iwata M. Y. Ohoka, T. Kuwata, and A. Asada
Stem Cells   14(6) 632-641   1996   [Invited]
Ohoka Y, Kuwata T, Tozawa Y, Zhao Y, Mukai M, Motegi Y, Suzuki R, YokoyamaA M, Iwata M
Int Immunol   8(3) 297-306   1996   [Refereed]
Regulation of apoptosis via steroid receptors
Makoto Iwata
Current Topics in Microbiology and Immunology   200 81-94   1995   [Invited]
Calcineurin activation protects T cells from glucocorticoid-induced apoptosis
Zhao Y, Tozawa Y, Iseki R, Mukai M, and Iwata M
J Immunol   154 6346-6354   1995   [Refereed]
Iwata M, Iseki R, Sato K, Tozawa Y, and Ohoka Y
Int Immunol   6 431-438   1994   [Refereed]
Ohoka Y, Nakai Y, Mukai M, Iwata M
Biochem Biophys Res Commun   197 916-921   1993   [Refereed]
Early mobilization of Ca2+ is not required for glucocorticoid-induced apoptosis in thymocytes
Iseki R, Kudo Y, and Iwata M
J Immunol   151 5198-5207   1993   [Refereed]
Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes.
Makoto Iwata, Mutsumi Mukai, Yuji Nakai, and Rieko Iseki
J Immunol   149(10) 3302-3308   Nov 1992   [Refereed]
Regulation of T lymphocyte apoptosis: Signals for the antagonism between activation- and glucocorticoid-induced death
Iseki R, Mukai M, and Iwata M
J Immunol   147 4286-4292   1991   [Refereed]
Katamura K, Iwata M, Mori A, and Ishizaka K
Proc Natl Acad Sci USA   87 1903-1907   1990   [Refereed]
Relationship between T cell receptors and antigen-binding factors. III. Association of antigen-binding glycosylation inhibiting factor with plasma membranes of Ts hybridomas
Iwata M, Katamura K, Mori A, Yamaguchi K, Grey H, and Ishizaka K
J Immunol   145 3578-3588   1990   [Refereed]
Carini C, Iwata M, Warner J, and Ishizaka K
I Immunol Methods   127 221-234   1990   [Refereed]
Effect of phosphlipase A2 inhibitors on mouse T lymphocytes. II. Phospholipase A2 inhibitors induce T cell hybridomas and a T cell clone for the formation of glycosylation- inhibiting factor
Ohno H, Iwata M, Katamura K, and Ishizaka K
Int Immunol   2 257-266   1990   [Refereed]
Characteristics of carrier-specific regulatory T cells
Ishizaka K, Iwata M, and Katamura K
Res Immunol   140(3) 299-302   1989   [Invited]
A monoclonal antibody raised to lipomodulin recognizes T-suppressor factors in two independent hapten-specific suppressor networks
Steele JK, Kuchroo VK, Kawasaki H, Jayaraman S, Iwata M, Ishizaka K, and Dorf ME
J Immunol   142 2213-2220   1989   [Refereed]
Effect of phospholipase A2 inhibitors on mouse T lymphocytes. I. Phospholipase A2 inhibitors exert similar immunological activities as glycosylation inhibiting factor
Ohno H, Iwata M, Nakamura T, and Ishizaka K
Int Immunol   1 425-433   1989   [Refereed]
Relationship between T cell receptors and antigen-binding factors. I. Specificity of functional T cell receptors on mouse T cell hybridomas that produce antigen-binding T cell factors
Iwata M, Katamura K, Kubo RT, and Ishizaka K
J Immunol   143 3909-3916   1989   [Refereed]
Relationship between T cell receptors and antigen-binding factors. II. Common antigenic determinants and epitope recognition shared by T cell receptors and antigen-binding factors
Iwata M, Katamura K, Kubo RT, Grey HM, and Ishizaka K
J Immunol   143 3917-3924   1989   [Refereed]
Antigen-specific T cells that form IgE-potentiating factor, IgG-potentiating factor and antigen-specific glycosylation enhancing factor on antigenic stimulation
Iwata M, Adachi M, and Ishizaka K
J Immunol   140 2534-2542   1988   [Refereed]
Construction of antigen-specific suppressor T cell hybridomas from spleen cells of mice primed for the persistent IgE antibody formation
Iwata M, and Ishizaka K
J Immunol   141 3270-3277   1988   [Refereed]
T cell factors involved in the regulation of the IgE synthesis
Ishizaka K, Jardieu P, Akasaki M, and Iwata M.
Int Archs Allergy appl Immunol   82 383-388   1987   [Invited]
Fukutomi Y, Hashimoto T, and Iwata M
Cell Immunol   105 187-198   1987   [Refereed]
Release of Histamine and arachidonate from mouse mast cells induced by glycosylation-enhancing factor and bradykinin
Ishizaka T, Iwata M, and Ishizaka K
J Immunol   134 1880-1887   1985   [Refereed]
Modulation of the biologic activities of IgE-binding factors. VII. Biochemical mechanisms by which glycosylation-enhancing factor activates phospholipase in lymphocytes
Akasaki M, Iwata M, and Ishizaka K
J Immunol   135 4069-4077   1985   [Refereed]
Modulation of the biologic activities of IgE-binding factor. V. The role of glycosylation-enhancing factor and glycosylation-inhibiting factor in determining the nature of IgE-binding factors
Iwata M, Huff TF, and Ishizaka K
J Immunol   132 1286-1293   1984   [Refereed]
Modulation of the biologic activities of IgE-binding factor. VI. The activation of phospholipase by glycosylation enhancing factor
Iwata M, Akasaki M, and Ishizaka K
J Immunol   133 1505-1512   1984   [Refereed]
Modulation of the biologic activities of IgE-binding factor. II. Physicochemical properties and cell sources of glycosylation-enhancing factor
Iwata M, Huff TF, Uede T, Munoz JJ, and Ishizaka K
J Immunol   130 1802-1808   1983   [Refereed]
Role of lipomodulin, a phospholipase inhibitory protein, in immunoregulation by thymocytes
Hirata F, and Iwata M
J Immunol   130 1930-1936   1983   [Refereed]
Modulation of the biologic activities of IgE-binding factors. III. Switching of a T cell hybrid clone from the formation of IgE-suppressive factor to the formation of IgE-potentiating factor
Huff TF, Uede T, Iwata M, and Ishizaka K
J Immunol   131 1090-1095   1983   [Refereed]
Modulation of the biologic activities of IgE-binding factor. IV. Identification of glycosylation-enhancing factor as a kallikrein-like enzyme
Iwata M., Munoz JJ, and Ishizaka K
J Immunol   131 1954-1960   1983   [Refereed]
F. Hirata, Y. Notsu, M. Iwata, L. Parente, M. DiRosa, R. J. Flower
Biochemical and Biophysical Research Communications   109 223-230   Nov 1982
Radioimmunoassay of lipomodulin has been developed using a monoclonal anti-lipomodulin antibody and125I-labelled lipomodulin. Lipomodulin activity was measured in peritoneal lavage fluids obtained from rats injected with dexamethasone by radioimmu...
Toyoshima Satoshi, Hirata Fusao, Iwata Makoto, Julius Axelrod, Osawa Toshiaki, M. J. Waxdal
Molecular Immunology   19 467-475   Jan 1982
The binding of the mitogenic lectins concanavalin A, Wistaria floribunda mitogen, Pisum sativum hemagglutinin, Lens culinaris lectin, phytohemagglutinin, and two of the pokeweed mitogens (Pa-1 and Pa-2), in mitogenic concentrations to the cell sur...
Yoshiko Kimura, Makoto Iwata, Yasuo Masuzawa, Toshiaki Osawa
International Archives of Allergy and Immunology   61 417-423   Jan 1980
Various lectins, mainly T cell mitogens, were examined to determine the relationship between anti-Ia antiserum-treated T cell responses and the sugar specificities of these lectins. Anti-Ia antiserum and complement treatment diminished nylon wool ...
Makoto Iwata, Toshiaki Osawa
Cellular Immunology   52 275-284   Jan 1980
Ia-bearing cells are required for the concanavalin A (Con A)-induced T-lymphocyte proliferative response. We attempted to determine how and when the Ia-bearing cells are required in this response. As Ia-bearing cells, mitomycin C-treated nylon woo...
Makoto Iwata, Hayao Ide, Tadao Terao, Toshiaki Osawa
Journal of Biochemistry   82 661-669   Jan 1977
The major glycoproteins which bind various lectins (Bauhinia purpurea, Lens culinaris, Pisum sativum, Ricinus communis, and wheat germ hemagglutinins) were isolated from splenic lymphocytes of DD-mice. The surface of the cells was radioiodinated u...
Satoshi Toyoshima, Makoto Iwata, Toshiaki Osawa
Nature   264 447-449   Dec 1976
AN important problem pertinent to the mechanism of lymphocyte stimulation with a nonspecific mitogen is how long lymphocytes must be exposed to the mitogen to attain maximal stimulation. In the case of the stimulation of human and murine lymphocyt...

Books etc

 
Retinoids and the immune system
Mora JR, and Iwata M (Part:Joint Work, The Retinoids: Biology, Biochemistry, and Disease. Part IV: Retinoids and Physiological Functions, Chapter 21, p.465-483, P. Dollé and K. Niederreither, eds.)
Wiley-Blackwell   Jun 2015   ISBN:978-1-118-62798-3
Retinoic acid production by intestinal dendritic cells
Iwata M, and Yokota A (Part:Joint Work, Vitamins & Hormones, Volume 86, “Vitamins and The Immune System” Chapter Six, p.127-152, G. Litwack, ed)
Elsevier   2011   
Regulation of thymocyte apoptosis: Glucocorticoid-induced death and its inhibition by T-cell receptor/CD3 complex-mediated stimulation
Iwata M, Iseki R, and Kudo Y (Part:Joint Work, Programmed Cell Death: The Cellular and Molecular Biology of Apoptosis, p.31-44, M. Lavin and D. Watters, eds)
Harwood Academic Publishers, Switzerland   1993   ISBN:371865461X
The origin and nature of antigen-binding factors having affinity for nominal antigens
Ishizaka K, Iwata M, Ohno H, Katamura K, Kubo RT, and Grey HM (Part:Joint Work, Molecular Aspects of Immune Response and Infectious Diseases, p.119-131)
Raven Press   1990   
Antigen-specific factors in IgE regulation
Ishizaka K, Iwata M, Carini C, Katamura K, and Takeuchi T (Part:Joint Work, Regulating the Allergic Response. Cytokines, Vol.2, p.1-17)
Karger Basel   1989   
Role of glycosylation inhibiting factor (GIF), a phospholipase inhibitory protein, in the generation of antigen-specific suppressor T cells
Iwata M., Akasaki M, Jardieu P, and Ishizaka K (Part:Joint Work, Molecular Basis of Lymphokine Action, p.21-31)
Humana Press   1987   
Biochemical basis of the adjuvant effects of pertussis toxin for the IgE response
Ishizaka K, Iwata M, Akasaki M, Ishizaka T, and Munoz JJ (Part:Joint Work, Pertussis Toxin, p.185-204)
Academic Press   1985   
Biochemical cascade of lipid metabolism in activated lymphocytes
Hirata F, Axelrod J, Iwata M, Waxdal MJ, Toyoshima S, Beppu M, and Osawa T (Part:Joint Work, Mechanism of Lymphocyte Activation, p.41-46)
Elsevier   1981   

Conference Activities & Talks

 
Regulation of immunity and allergy by retinoic acid [Invited]
IWATA Makoto
Frontier of Genomic Medicine“Retinoid (Am80, Tamibarotene) as therapeutics for intractable diseases”   30 Jan 2018   
The role of retinoic acid in immune functions [Invited]
IWATA Makoto
The 3rd International Conference on Retinoids (26th Congress of the Japanese Society for Retinoid Research)   22 Oct 2015   
The role of retinoic acid in immune functions [Invited]
IWATA Makoto
Academy of Immunology and Microbiology (AIM), The Institute for Basic Science (IBS) in Pohang University of Science and Technology (POSTECH) (Director, Prof. Surh)   27 May 2015   
The role of retinoic acid signals in immune functions [Invited]
IWATA Makoto
International Symposium “New Horizons in The Immune System”- A Strategic Project for Innovative Research   Feb 2012   
The effect of chemicals on the tissue-specific homing of T cells [Invited]
IWATA Makoto
International Council of Chemical Associations (ICCA) - Long-range Research Initiative (LRI) & Joint Research Centre (JRC) WORKSHOP 2010   Jun 2010   
Regulation of immunological functions by vitamin A [Invited]
IWATA Makoto
International Symposium 2009 - Nutritional, Medical and Social Sciences for Children   23 Jan 2009   
Regulation of lymphocyte homing by retinoids [Invited]
IWATA Makoto
The Korean Association of Immunobiologists, 55th Fall Conference   9 Nov 2007   
Role of vitamin A in Lymphocyte Homing to The Gut [Invited]
IWATA Makoto
13th International Congress of Mucosal Immunology (ICMI2007)/ Japanese Association for Food Immunology (JAFI), Joint Meeting   11 Jul 2007   
The role of dendritic cells and retinoids in regulating lymphocyte trafficking [Invited]
IWATA Makoto
2006 BMT (The American Society for Blood and Marrow Transplantation) Tandem Meetings, Plenary Session “Cell Trafficking and Homing”   Feb 2006   
The role of retinoids regulating lymphocyte trafficking [Invited]
IWATA Makoto
Medizinishe Hochschule Hannover (Prof. Förster)   19 Oct 2005   
The role of retinoids regulating lymphocyte trafficking [Invited]
IWATA Makoto
Charite-Universitaetsmedizin Berlin, Medizinische Klinik mit Scherpunkt, Rheumatologie und Klinche Immunologie (Prof. Hamann)   18 Oct 2005   
Role of vitamin A in the imprinting of gut-homing T cells [Invited]
IWATA Makoto
The 14th International Symposium on Molecular Cell Biology of Macrophages 2005   2005   
Retinoic acid imprints gut-homing specificity on T cells. [Invited]
IWATA Makoto
Keystone Symposia, Leukocyte Trafficking: Cellular and Molecular Mechanisms   2005   
A role of calcineurin in thymocyte differentiation [Invited]
IWATA Makoto
TMIN (Tokyo Metropolitan Institute for Neuroscience) Symposium '96, Protein Phosphatases & Cellular Regulation   1996   
Regulation of T cell apoptosis via T cell receptors and steroid receptors [Invited]
IWATA Makoto
Keystone Simposia on Molecular & Cellular Biology, Apoptosis (Programmed Cell Death)   1995   
Regulation of thymocyte apoptosis: Glucocorticoid-induced death and its inhibition by the stimulation via the T-cell receptor/CD3 complex
IWATA Makoto
The 2nd Bancroft Symposium, Cell and Molecular Biology of Apoptosis (Programmed Cell Death)   1992   

Research Grants & Projects

 
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: Apr 2019 - Mar 2022    Investigator(s): IWATA Makoto
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: Apr 2014 - Mar 2017    Investigator(s): IWATA Makoto
The Japanese Ministry of Education, Culture, Sports, Science and Technology: Grant-in-Aid for Scientific Research on Innovative Areas
Project Year: Apr 2013 - Mar 2015    Investigator(s): IWATA Makoto
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: Apr 2011 - Mar 2014    Investigator(s): IWATA Makoto
The Uehara Memorial Foundation: Research Grant
Project Year: 2013 - 2014    Investigator(s): IWATA Makoto
Regulation of mucosal immunity by the regulation of retinoic acid production in dendritic cells
JST Basic Research Programs (Core Research for Evolutional Science and Technology :CREST)
Project Year: Oct 2008 - Mar 2013    Investigator(s): IWATA Makoto
The Japanese Ministry of Education, Culture, Sports, Science and Technology: Grant-in-Aid for Scientific Research on Priority Areas
Project Year: Apr 2010 - Mar 2012    Investigator(s): IWATA Makoto
The Danone Institute of Japan: Research Grant
Project Year: Jan 2010 - Dec 2010    Investigator(s): IWATA Makoto
The Japanese Ministry of Education, Culture, Sports, Science and Technology: Grant-in-Aid for Scientific Research on Priority Areas
Project Year: Apr 2008 - Mar 2010    Investigator(s): IWATA Makoto
Japan Society for the Promotion of Science: Grant-in-Aid for Exploratory Research
Project Year: Apr 2007 - Mar 2009    Investigator(s): IWATA Makoto
The Uehara Memorial Foundation: Research Grant
Project Year: 2008 - 2009    Investigator(s): IWATA Makoto
Japan Chemical Industry Association: Long-range Research Initiative (LRI) grant
Project Year: 2008 - 2009    Investigator(s): IWATA Makoto
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research on Priority Areas
Project Year: Apr 2005 - Mar 2008    Investigator(s): IWATA Makoto
Japan Chemical Industry Association: Long-range Research Initiative (LRI) Grant
Project Year: 2007 - 2008    Investigator(s): IWATA Makoto
The Japanese Ministry of Education, Culture, Sports, Science and Technology: Grant-in-Aid for Scientific Research on Priority Areas
Project Year: Apr 2005 - Mar 2007    Investigator(s): IWATA Makoto
Japan Chemical Industry Association: Long-range Research Initiative (LRI) Grant
Project Year: 2006 - 2007    Investigator(s): IWATA Makoto
The Naito Foundation: Research Grant
Project Year: 2006 - 2007    Investigator(s): IWATA Makoto
Immune cell homing
Grant-in-Aid for Scientific Research
Project Year: 2002   
T cell differentiation
The Other Research Programs
Project Year: 1989