西屋禎 (Tadashi Nishiya) - マイポータル

基本情報

所属: 奥羽大学薬学部教授

学位: 博士 (薬学）(北海道大学)
薬学修士(北海道大学)

J-GLOBAL ID: 200901037787170470
researchmap会員ID: 5000097466

研究キーワード

研究分野

経歴

2014年4月 - 現在

奥羽大, 薬, 教授
2011年10月 - 2014年3月

岡山大, 薬, 准教授
2006年10月 - 2011年9月

北大, 医, 講師
2005年2月 - 2006年9月

北大, 医, 助手
2005年 - 2006年

Research Associate
2006年

- Lecturer
2000年3月 - 2005年2月

UCSF, ポスドク
1999年5月 - 2000年2月

NIH, ポスドク
1997年4月 - 1999年3月

学振 DC2
1997年 - 1999年

Postdoctoral Fellowships of Japan Society for the Promotion of Science

学歴

1996年4月 - 1999年3月

北大, 院薬, 博士
1994年4月 - 1996年3月

北大, 院薬, 修士
1991年10月 - 1994年3月

北大, 薬, 製薬化
1987年4月 - 1990年3月

弘前大, 理, 地球科

論文

S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein.

Kana Fujikawa, Kengo Nakahara, Nobumasa Takasugi, Tadashi Nishiya, Akihiro Ito, Koji Uchida, Takashi Uehara

Biochemical and biophysical research communications 524(4) 910-915 2020年4月16日査読有り
TRAV7-2*02 Expressing CD8⁺ T Cells Are Responsible for Palladium Allergy.

Yuri Takeda, Yoshiko Suto, Koyu Ito, Wataru Hashimoto, Tadashi Nishiya, Kyosuke Ueda, Takayuki Narushima, Tetsu Takahashi, Kouetsu Ogasawara

International journal of molecular sciences 18(6) 1162 (12 pages) 2017年5月31日査読有り
Correlation between attenuation of protein disulfide isomerase activity through S-mercuration and neurotoxicity induced by methylmercury.

Kento Makino, Kosaku Okuda, Eisuke Sugino, Tadashi Nishiya, Takashi Toyama, Takao Iwawaki, Masatake Fujimura, Yoshito Kumagai, Takashi Uehara

Neurotoxicity research 27(2) 99-105 2015年2月
NKG2D⁺ IFN-γ⁺ CD8⁺ T cells are responsible for palladium allergy.

Mitsuko Kawano, Masafumi Nakayama, Yusuke Aoshima, Kyohei Nakamura, Mizuho Ono, Tadashi Nishiya, Syou Nakamura, Yuri Takeda, Akira Dobashi, Akiko Takahashi …

PloS one 9(2) e86810 2014年
Adenylate cyclase/cAMP/protein kinase A signaling pathway inhibits endothelin type A receptor-operated Ca²⁺ entry mediated via transient receptor potential canonical 6 channels.

Horinouchi T, Higa T, Aoyagi H, Nishiya T, Terada K, Miwa S

The Journal of pharmacology and experimental therapeutics 340 143-151 2012年1月査読有り
Nicotine- and Tar-Free Cigarette Smoke Induces Cell Damage Through Reactive Oxygen Species Newly Generated by PKC-Dependent Activation of NADPH Oxidase

Asano Hiroshi, Horinouchi Takahiro, Mai Yosuke, Sawada Osamu, Fujii Shunsuke, Nishiya Tadashi, Minami Masabumi, Katayama Takahiro, Iwanaga Toshihiko, Terada Koji …

Journal of Pharmacological Sciences 118(2) 275-287 2012年査読有り
On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN).

Naoki Numajiri, Kumi Takasawa, Tadashi Nishiya, Hirotaka Tanaka, Kazuki Ohno, Wataru Hayakawa, Mariko Asada, Hiromi Matsuda, Kaoru Azumi, Hideaki Kamata …

Proceedings of the National Academy of Sciences of the United States of America 108(25) 10349-54 2011年6月21日
The ECS(SPSB) E3 ubiquitin ligase is the master regulator of the lifetime of inducible nitric-oxide synthase.

Matsumoto K, Nishiya T, Maekawa S, Horinouchi T, Ogasawara K, Uehara T, Miwa S

Biochemical and biophysical research communications 409(1) 46-51 2011年5月査読有り
Regulation of Inducible Nitric-oxide Synthase by the SPRY Domain- and SOCS Box-containing Proteins

Tadashi Nishiya, Kazuma Matsumoto, Satoshi Maekawa, Emi Kajita, Takahiro Horinouchi, Masahiro Fujimuro, Kouetsu Ogasawara, Takashi Uehara, Soichi Miwa

JOURNAL OF BIOLOGICAL CHEMISTRY 286(11) 9009-9019 2011年3月査読有り
Function and regulation of endothelin type A receptor-operated transient receptor potential canonical channels.

Horinouchi T, Terada K, Higa T, Aoyagi H, Nishiya T, Suzuki H, Miwa S

Journal of pharmacological sciences 117(4) 295-306 2011年査読有り
OCTN2VT, a splice variant of OCTN2, does not transport carnitine because of the retention in the endoplasmic reticulum caused by insertion of 24 amino acids in the first extracellular loop of OCTN2.

Satoshi Maekawa, Daisuke Mori, Tadashi Nishiya, Osamu Takikawa, Takahiro Horinouchi, Arata Nishimoto, Emi Kajita, Soichi Miwa

Biochimica et biophysica acta 1773(6) 1000-6 2007年6月

MISC

Screening systems for the identification of S-nitrosylated proteins

Takashi Uehara, Tadashi Nishiya

NITRIC OXIDE-BIOLOGY AND CHEMISTRY 25(2) 108-111 2011年8月
Regulation of inducible nitric oxide synthase by the SPRY domain- and SOCS box-containing proteins.

Journal of Biological Chemistry in press 2011年
Endothelin Type B Receptor-Induced Sustained Ca2+ Influx Involves G(q/11)/Phospholipase C-Independent, p38 Mitogen-Activated Protein Kinase-Dependent Activation of Na+/H+ Exchanger

Tsunaki Higa, Takahiro Horinouchi, Hiroyuki Aoyagi, Hiroshi Asano, Tadashi Nishiya, Arata Nishimoto, Ikunobu Muramatsu, Soichi Miwa

JOURNAL OF PHARMACOLOGICAL SCIENCES 113(3) 276-280 2010年7月
Jab1 regulates levels of endothelin type A and B receptors by promoting ubiquitination and degradation

Arata Nishimoto, Lingyun Lu, Misato Hayashi, Tadashi Nishiya, Takahiro Horinouchi, Soichi Miwa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 391(4) 1616-1622 2010年1月
Differential Coupling of Human Endothelin Type A Receptor to G(q/11) and G(12) Proteins: the Functional Significance of Receptor Expression Level in Generating Multiple Receptor Signaling

Takahiro Horinouchi, Hiroshi Asano, Tunaki Higa, Arata Nishimoto, Tadashi Nishiya, Ikunobu Muramatsu, Soichi Miwa

JOURNAL OF PHARMACOLOGICAL SCIENCES 111(4) 338-351 2009年12月
Functional role of Na+/H+ exchanger in Ca2+ influx mediated via human endothelin type A receptor stably expressed in Chinese hamster ovary cells

Takahiro Horinouchi, Yumie Miyake, Tadashi Nishiya, Arata Nishimoto, Shigeru Morishima, Ikunobu Muramatsu, Soichi Miwa

JOURNAL OF PHARMACOLOGICAL SCIENCES 107(4) 456-459 2008年8月
Characterization of noradrenaline-induced increases in intracellular Ca2+ levels in Chinese hamster ovary cells stably expressing human alpha(1A)-adrenoceptor

Takahiro Horinouchi, Yumie Miyake, Tadashi Nishiya, Arata Nishimoto, Shoko Yorozu, Atsushi Jinno, Emi Kajita, Soichi Miwa

JOURNAL OF PHARMACOLOGICAL SCIENCES 105(1) 103-111 2007年9月
Endothelin-1 decreases [Ca2+](i) via Na+/Ca2+ exchanger in CHO cells stably expressing endothelin ETA receptor

Takahiro Horinouchi, Arata Nishimoto, Tadashi Nishiya, Lingyun Lu, Emi Kajita, Soichi Miwa

EUROPEAN JOURNAL OF PHARMACOLOGY 566(1-3) 28-33 2007年7月
Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88

Tadashi Nishiya, Emi Kajita, Takahiro Horinouchi, Arata Nishimoto, Soichi Miwa

FEBS LETTERS 581(17) 3223-3229 2007年7月
OCTN2VT, a splice variant of OCTN2, does not transport carnitine because of the retention in the endoplasmic reticulum caused by insertion of 24 amino acids in the first extracellular loop of OCTN2

Satoshi Maekawa, Daisuke Mori, Tadashi Nishiya, Osamu Takikawa, Takahiro Horinouchi, Arata Nishimoto, Emi Kajita, Soichi Miwa

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1773(6) 1000-1006 2007年6月
Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages

Gorazd Drozina, Jiri Kohoutek, Tadashi Nishiya, B. Matija Peterlin

JOURNAL OF BIOLOGICAL CHEMISTRY 281(52) 39963-39970 2006年12月
Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2

Kazuhiko Nagai, Osamu Takikawa, Naoko Kawakami, Mitsuhiro Fukao, Takamitsu Soma, Atsushi Oda, Tadashi Nishiya, Misato Hayashi, Lingyun Lu, Manabu Nakano …

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 452(1) 29-37 2006年8月
The transmembrane domain directs TLR9 to intracellular compartments that contain TLR3

E Kajita, T Nishiya, S Miwa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 343(2) 578-584 2006年5月
Ligand-independent oligomerization of TLR4 regulated by a short hydrophobic region adjacent to the transmembrane domain

T Nishiya, E Kajita, S Miwa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 341(4) 1128-1134 2006年3月
Involvement of polyubiquitin chains via specific chain linkages in stress response in mammalian cells

M Fujimuro, T Nishiya, Y Nomura, H Yokosawa

BIOLOGICAL & PHARMACEUTICAL BULLETIN 28(12) 2315-2318 2005年12月
TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements

T Nishiya, E Kajita, S Miwa, AL DeFranco

JOURNAL OF BIOLOGICAL CHEMISTRY 280(44) 37107-37117 2005年11月
Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the toll-like receptors

T Nishiya, AL DeFranco

JOURNAL OF BIOLOGICAL CHEMISTRY 279(18) 19008-19017 2004年4月
Involvement of nuclear factor-kappa B (NF-kappa B) signaling in the expression of inducible nitric oxide synthase (iNOS) gene in rat C6 glioma cells

T Nishiya, T Uehara, M Kaneko, Y Nomura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 275(2) 268-273 2000年8月
Transient nuclear factor kappaB (NF-kappaB) activation stimulated by interleukin-1beta may be partly dependent on proteasome activity, but not phosphorylation and ubiquitination of the IkappaBalpha molecule, in C6 glioma cells. Regulation of NF-kappaB ・・・

UEHARA T, MATSUNO J, KANEKO M, NISHIYA T, FUJIMURO M, YOKOSAWA H, NOMURA Y

Journal of Biological Chemistry 274(22) 15875-15882 1999年5月
The intracellular mechanism of NF-kappa B activation involved in iNOS and chemokine induction in C6 glioma cells

日本薬理学雑誌 114(1) 92-95 1999年

もっとみる

西屋禎

基本情報

研究キーワード

研究分野

経歴

学歴

論文

MISC

所属学協会

Works(作品等)

共同研究・競争的資金等の研究課題

メニュー

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