Kubota, Yoshiaki

J-GLOBAL         Last updated: Aug 24, 2019 at 02:53
Kubota, Yoshiaki
Keio University
School of Medicine Department of Anatomy
Job title
医学博士(Keio University)
Research funding number

Research Areas


Academic & Professional Experience

Apr 2000
Mar 2002
resident, Dept of Plastic Surgery, School of Medicine, Keio University
Apr 2006
Oct 2008
Non-tenured instructor, Dept of Cell Differentiation, School of Medicine, Keio University
Nov 2008
Mar 2013
Tenure track assistant professor, Center for Integrated Medical Research (Keio Kanrinmaru Project), School of Medicine, Keio University
Dec 2011
Jul 2012
Visiting Researcher, Laboratory of Stem Cell and Neurovascular Development and Patterning, National Institutes of Health
Apr 2013
Apr 2015
Principal Investigator (Associate professor), The Laboratory of Vascular Biology, School of Medicine, Keio University


Apr 1994
Mar 2000
School of Medicine, Keio University
Apr 2003
Mar 2006
School of Medicine, Keio University

Awards & Honors

Keio Medical School Faculty and Alumni Grants, Keio University
Winner: Yoshiaki Kubota
Kao Research Encouragement Award
Winner: Yoshiaki Kubota
Young Investigator Okamoto Award
Winner: Yoshiaki Kubota
Kitasato Award, Keio University
Winner: Yoshiaki Kubota
Hematology/Vascular Research Orbis Young Investigator Award (1st Pzize)
Winner: Yoshiaki Kubota

Published Papers

Kim Y., Choi J., Yang M., Hong S., Lee C., Kubota Y., Lim D., Koh G.
Nature Communications   10(1)    Dec 2019
© 2019, The Author(s). Hypoxia is a main driver of sprouting angiogenesis, but how tip endothelial cells are directed to hypoxic regions remains poorly understood. Here, we show that an endothelial MST1–FOXO1 cascade is essential for directional m...
Yokoyama M., Shimizu I., Nagasawa A., Yoshida Y., Katsuumi G., Wakasugi T., Hayashi Y., Ikegami R., Suda M., Ota Y., Okada S., Fruttiger M., Kobayashi Y., Tsuchida M., Kubota Y., Minamino T.
Journal of Molecular and Cellular Cardiology   129 105-117   Apr 2019
© 2019 Elsevier Ltd p53 is a guardian of the genome that protects against carcinogenesis. There is accumulating evidence that p53 is activated with aging. Such activation has been reported to contribute to various age-associated pathologies, but i...
Kim J., Park J., Choi J., Park I., Hwang Y., Bae H., Kim Y., Choi W., Yang J., Han S., Chung T., Kim P., Kubota Y., Augustin H., Oh W., Koh G.
Science Advances   5(2)    Feb 2019
Copyright © 2019 The Authors. Choriocapillary loss is a major cause of neovascular age-related macular degeneration (NV-AMD). Although vascular endothelial growth factor (VEGF) blockade for NV-AMD has shown beneficial outcomes, unmet medical needs...
Naito H., Iba T., Wakabayashi T., Tai-Nagara I., Suehiro J., Jia W., Eino D., Sakimoto S., Muramatsu F., Kidoya H., Sakurai H., Satoh T., Akira S., Kubota Y., Takakura N.
Developmental Cell   48(2) 151-166.e7   Jan 2019
© 2018 Elsevier Inc. Mechanisms by which endothelial cells (ECs) maintain themselves in inflammatory microenvironments remain unclear. Naito et al. show that TAK1 prevents EC apoptosis induced by TNF-α-expressing myeloid cells. TAK1 protects ECs a...
Lee S., Lee C., Kang S., Park I., Kim Y., Kim S., Hong S., Bae H., He Y., Kubota Y., Koh G.
Journal of Clinical Investigation   128(11) 5018-5033   Nov 2018
© 2018 American Society for Clinical Investigation. All rights reserved. Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. However,...

Teaching Experience


Research Grants & Projects

Analysis for organ-specific vascular patterning
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2019 - Mar 2022    Investigator(s): 久保田 義顕
Mechanisms for specification of blood and lymphatic vessels
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Jun 2018 - Mar 2020    Investigator(s): 久保田 義顕
Regulatory mechanisms of microglial activation and neuropsychiatric disorders
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2018 - Mar 2020    Investigator(s): 久保田 義顕
Role of the VEGF/VEGFR2 signaling in vascular stability
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2015 - Mar 2017    Investigator(s): 久保田 義顕
Blood vessels are distributed throughout the body during development. This developmental process depends on the signaling of vascular endothelial growth factor (VEGF) and its main receptor, VEGFR2. However, the precise role of VEGF on vascular end...
Strategy to improve the quality of wound angiogenesis
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2013 - Mar 2017    Investigator(s): 久保田 義顕
Once skin tissues are injured, the endogenous healing program takes place and damaged tissues are repaired or regenerated. Angiogenesis, formation of new blood vessels from nascent vessels, are believed to play a central role in this repairing pro...