論文

査読有り 国際誌
2020年4月15日

Functional near-infrared-spectroscopy-based measurement of changes in cortical activity in macaques during post-infarct recovery of manual dexterity.

Scientific reports
  • Junpei Kato
  • ,
  • Toru Yamada
  • ,
  • Hiroshi Kawaguchi
  • ,
  • Keiji Matsuda
  • ,
  • Noriyuki Higo

10
1
開始ページ
6458
終了ページ
6458
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-63617-0

Because compensatory changes in brain activity underlie functional recovery after brain damage, monitoring of these changes will help to improve rehabilitation effectiveness. Functional near-infrared spectroscopy (fNIRS) has the potential to measure brain activity in freely moving subjects. We recently established a macaque model of internal capsule infarcts and an fNIRS system for use in the monkey brain. Here, we used these systems to study motor recovery in two macaques, for which focal infarcts of different sizes were induced in the posterior limb of the internal capsule. Immediately after the injection, flaccid paralysis was observed in the hand contralateral to the injected hemisphere. Thereafter, dexterous hand movements gradually recovered over months. After movement recovery, task-evoked hemodynamic responses increased in the ventral premotor cortex (PMv). The response in the PMv of the infarcted (i.e., ipsilesional) hemisphere increased in the monkey that had received less damage. In contrast, the PMv of the non-infarcted (contralesional) hemisphere was recruited in the monkey with more damage. A pharmacological inactivation experiment with muscimol suggested the involvement of these areas in dexterous hand movements during recovery. These results indicate that fNIRS can be used to evaluate brain activity changes crucial for functional recovery after brain damage.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-63617-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32296087
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160113
ID情報
  • DOI : 10.1038/s41598-020-63617-0
  • PubMed ID : 32296087
  • PubMed Central 記事ID : PMC7160113

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