2018年1月1日
Utilization of proteins and peptides to create organic-hydroxyapatite hybrids
Protein and Peptide Letters
- ,
- 巻
- 25
- 号
- 1
- 開始ページ
- 25
- 終了ページ
- 33
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.2174/0929866525666171221115033
- 出版者・発行元
- Bentham Science Publishers B.V.
Background: Various types of proteins play important roles in the biomineralization of hydroxyapatite (HAp, Ca10(PO4)6(OH)2). The resulting organic-HAp nanohybrids have highlyorganized hierarchical structures that show unique morphological, structural, and mechanical properties. By mimicking the biomineralization process, organic-HAp hybrid materials have been created by utilizing proteins and peptides. Objectives: In this review, firstly the roles of proteins in HAp mineralization in vivo are briefly explained. Recent progresses in the creation of organic-HAp hybrids through the utilization of proteins and peptides are then described. Results: Roles of collagen and amelogenin on the formation of bones and teeth were explained. Then, recent advances, including those by the authors, in the creation of organic-HAp hybrids through the utilization of these proteins, their derivatives, and synthetic peptides, including engineering-isolated ones, were reviewed. Conclusion: Organic-HAp hybrid materials have been intensively created by utilizing proteins and peptides. Among them, engineering-isolated or rationally designed peptides and their derivatives represent future promising building components for organic-HAp hybrids with precise hierarchical structures. Not only the excellent functions of the resultant hybrids materials, but also the creation of materials by biomimetic synthetic processes at a low cost and environmental burden are important for sustainable industrial development.
- ID情報
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- DOI : 10.2174/0929866525666171221115033
- ISSN : 1875-5305
- ISSN : 0929-8665
- SCOPUS ID : 85047796445