論文

2004年2月

Tissue plasminogen activator levels after single intracisternal injection in patients with subarachnoid hemorrhage

NEUROLOGIA MEDICO-CHIRURGICA
  • J Jito
  • ,
  • Y Nakasu
  • ,
  • S Nakasu
  • ,
  • N Hatsuda
  • ,
  • M Matsuda

44
2
開始ページ
55
終了ページ
60
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2176/nmc.44.55
出版者・発行元
JAPAN NEUROSURGICAL SOC

Tissue plasminogen activator (tPA) levels were investigated in the cisternal fluid of patients with subarachnoid hemorrhage treated with single intracisternal injection of recombinant tPA during radical surgery for ruptured aneurysms. Seven patients received different doses of tPA: two of 400 mug/ml, three of 500 mug/ml, one of 700 mug/ml, and one of 800 mug/ml in a total amount of 20 ml distilled water at pH 7. Cerebrospinal fluid samples were taken directly from the cisternal fluid at 15-minute incubation after injection, immediately after irrigation during surgery, and by lumbar tap 2 days after surgery. Cisternal tPA levels decreased to about 60% of the mean injected doses after 15-minute incubation. Simple linear regression analysis showed these tPA levels after incubation correlated with the initial doses. After copious irrigation with Ringer solution at pH 8, tPA levels decreased rapidly without correlation with the initial doses. After spinal drainage for 2 days, tPA levels further decreased by an order of 10(-4) to 10(-6) from the initial dose. These values were still greater than normal controls. The final values of tPA levels were not related to the initial dose. None of the patients suffered from systemic or wound complications. Cisternal tPA injection with increased doses and irrigation may be beneficial for the selective rapid removal of blood clots with controllable safety.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.2176/nmc.44.55
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000188943300001&DestApp=WOS_CPL

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