長谷川浩史 (Hiroshi Hasegawa) - マイポータル

基本情報

学位: 医学博士(京都大学)
医学博士(京都大学)

J-GLOBAL ID: 200901004292360979
researchmap会員ID: 5000104360

研究キーワード

アルツハイマー病

研究分野

ライフサイエンス / 病態医化学 /

経歴

2001年 - 2005年

トロント大学博士研究員
2005年

- 滋賀医科大学助手
1998年 - 2001年

兵庫県立高齢者脳機能研究センター研究員
滋賀医科大学分子神経科学研究センター滋賀医科大学分子神経科学研究センター, 客員助教

学歴

MISC

Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor

Naohiro Itoh, Masayasu Okochi, Shinji Tagami, Kouhei Nishitomi, Taisuke Nakayama, Kanta Yanagida, Akio Fukumori, Jingwei Jiang, Kohji Mori, Motoko Hosono …

NEURODEGENERATIVE DISEASES 6(5-6) 230-239 2009年
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Ekaterina Rogaeva, Yan Meng, Joseph H. Lee, Yongjun Gu, Toshitaka Kawarai, Fanggeng Zou, Taiichi Katayama, Clinton T. Baldwin, Rong Cheng, Hiroshi Hasegawa …

NATURE GENETICS 39(2) 168-177 2007年2月
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

ROGAEVA Ekaterina, ROGAEVA Ekaterina, MENG Yan, LEE Joseph H, GU Yongjun, GU Yongjun, KAWARAI Toshitaka, KAWARAI Toshitaka, ZOU Fanggeng, ZOU Fanggeng …

Nat Genetics 39(2) 168-177 2007年
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Nat Genetics 39(2) 168-177 2007年
Novel SPG6 mutation p.A100T in a Japanese family with autosomal dominant form of hereditary spastic paraplegia

Satoshi Kaneko, Toshitaka Kawarai, Edwin Yip, Shabnam Salehi-Rad, Christine Sato, Antonio Orlacchio, Giorgio Bernardi, Yan Liang, Hiroshi Hasegawa, Ekaterina Rogaeva …

MOVEMENT DISORDERS 21(9) 1531-1533 2006年9月
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

FS Chen, H Hasegawa, G Schmitt-Ulms, T Kawarai, C Bohm, T Katayama, YJ Gu, N Sanjo, M Glista, E Rogaeva …

NATURE 440(7088) 1208-1212 2006年4月
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

FS Chen, H Hasegawa, G Schmitt-Ulms, T Kawarai, C Bohm, T Katayama, YJ Gu, N Sanjo, M Glista, E Rogaeva …

NATURE 440(7088) 1208-1212 2006年4月
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

A Petit, T Kawarai, E Paitel, N Sanjo, M Maj, M Scheid, FS Chen, YJ Gu, H Hasegawa, S Salehi-Rad …

JOURNAL OF BIOLOGICAL CHEMISTRY 280(40) 34025-34032 2005年10月
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

A Petit, T Kawarai, E Paitel, N Sanjo, M Maj, M Scheid, FS Chen, YJ Gu, H Hasegawa, S Salehi-Rad …

JOURNAL OF BIOLOGICAL CHEMISTRY 280(40) 34025-34032 2005年10月
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

H Hasegawa, N Sanjo, FS Chen, YJ Gu, C Shier, A Petit, T Kawarai, T Katayama, SD Schmidt, PM Mathews …

JOURNAL OF BIOLOGICAL CHEMISTRY 279(45) 46455-46463 2004年11月
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

H Hasegawa, N Sanjo, FS Chen, YJ Gu, C Shier, A Petit, T Kawarai, T Katayama, SD Schmidt, PM Mathews …

JOURNAL OF BIOLOGICAL CHEMISTRY 279(45) 46455-46463 2004年11月
The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

YJ Gu, N Sanjo, FS Chen, H Hasegawa, A Petit, XY Ruan, WP Li, C Shier, T Kawarai, G Schmitt-Ulms …

JOURNAL OF BIOLOGICAL CHEMISTRY 279(30) 31329-31336 2004年7月
The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

YJ Gu, N Sanjo, FS Chen, H Hasegawa, A Petit, XY Ruan, WP Li, C Shier, T Kawarai, G Schmitt-Ulms …

JOURNAL OF BIOLOGICAL CHEMISTRY 279(30) 31329-31336 2004年7月
Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

A Tandon, H Yu, L Wang, E Rogaeva, C Sato, MA Chishti, T Kawarai, H Hasegawa, FS Chen, P Davies …

JOURNAL OF NEUROCHEMISTRY 86(3) 572-581 2003年8月
Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

A Tandon, H Yu, L Wang, E Rogaeva, C Sato, MA Chishti, T Kawarai, H Hasegawa, FS Chen, P Davies …

JOURNAL OF NEUROCHEMISTRY 86(3) 572-581 2003年8月
Aggregation analysis of the microtubule binding domain in tau protein by spectroscopic methods

TM Yao, K Tomoo, T Ishida, H Hasegawa, M Sasaki, T Taniguchi

JOURNAL OF BIOCHEMISTRY 134(1) 91-99 2003年7月
Aggregation analysis of the microtubule binding domain in tau protein by spectroscopic methods

TM Yao, K Tomoo, T Ishida, H Hasegawa, M Sasaki, T Taniguchi

JOURNAL OF BIOCHEMISTRY 134(1) 91-99 2003年7月
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in mammalian brain

FS Chen, A Tandon, N Sanjo, YJ Gu, H Hasegawa, S Arawaka, FJS Lee, XY Ruan, P Mastrangelo, S Erdebil …

JOURNAL OF BIOLOGICAL CHEMISTRY 278(22) 19974-19979 2003年5月
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in mammalian brain

FS Chen, A Tandon, N Sanjo, YJ Gu, H Hasegawa, S Arawaka, FJS Lee, XY Ruan, P Mastrangelo, S Erdebil …

JOURNAL OF BIOLOGICAL CHEMISTRY 278(22) 19974-19979 2003年5月
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin-nicastrin complexes

YJ Gu, FS Chen, N Sanjo, T Kawarai, H Hasegawa, M Duthie, WP Li, XY Ruan, A Luthra, HTJ Mount …

JOURNAL OF BIOLOGICAL CHEMISTRY 278(9) 7374-7380 2003年2月

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共同研究・競争的資金等の研究課題

アルツハイマー病における神経変性の分子機構に関する研究