菱木貴子 (Hishiki Takako) - マイポータル

基本情報

所属: 慶應義塾医学部医化学教室専任講師

研究者番号: 10338022
J-GLOBAL ID: 200901005225061114
researchmap会員ID: 5000105236

研究分野

ライフサイエンス / 医化学 /

論文

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle

HSuhara Tomohiro, HR, HHishiki Takako, HR, HKasahara Masataka, HR, HHayakawa Noriyo, HR, HOyaizu Tomoko, HR …

Proceedings of the National Academy of Sciences of the United States of America 112(37) 11642-11647 2015年9月15日査読有り
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle

Tomohiro Suhara, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, William G. Kaelin, Makoto Suematsu …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112(37) 11642-11647 2015年9月査読有り
Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions

Shintaro Nakano, Isao Ishii, Ken Shinmura, Kayoko Tamaki, Takako Hishiki, Noriyuki Akahoshi, Tomoaki Ida, Tsuyoshi Nakanishi, Shotaro Kamata, Yoshito Kumagai …

JOURNAL OF MOLECULAR MEDICINE-JMM 93(8) 879-889 2015年8月査読有り
Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart

Tomohiro Matsuhashi, Takako Hishiki, Heping Zhou, Tomohiko Ono, Ruri Kaneda, Tatsuya Iso, Aiko Yamaguchi, Jin Endo, Yoshinori Katsumata, Anzai Atsushi …

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 82 116-124 2015年5月
Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia

Toshiki Takenouchi, Yuki Sugiura, Takayuki Morikawa, Tsuyoshi Nakanishi, Yoshiko Nagahata, Tadao Sugioka, Kurara Honda, Akiko Kubo, Takako Hishiki, Tomomi Matsuura …

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 35(5) 794-805 2015年5月査読有り
Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

Ohmura, Mitsuyo, Hishiki, Takako, Yamamoto, Takehiro, Nakanishi, Tsuyoshi, Kubo, Akiko, Tsuchihashi, Kenji, Tamada, Mayumi, Toue, Sakino, Kabe, Yasuaki, Saya …

NITRIC OXIDE-BIOLOGY AND CHEMISTRY 46 102-113 2015年4月査読有り
Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

Mitsuyo Ohmura, Takako Hishiki, Takehiro Yamamoto, Tsuyoshi Nakanishi, Akiko Kubo, Kenji Tsuchihashi, Mayumi Tamada, Sakino Toue, Yasuaki Kabe, Hideyuki Saya …

NITRIC OXIDE-BIOLOGY AND CHEMISTRY 46 102-113 2015年4月査読有り
Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

Mitsuyo Ohmura, Takako Hishiki, Takehiro Yamamoto, Tsuyoshi Nakanishi, Akiko Kubo, Kenji Tsuchihashi, Mayumi Tamada, Sakino Toue, Yasuaki Kabe, Hideyuki Saya …

NITRIC OXIDE-BIOLOGY AND CHEMISTRY 46 102-113 2015年4月
Involvement of the yciW gene in L-cysteine and L-methionine metabolism in Escherichia coli

Yusuke Kawano, Iwao Ohtsu, Ai Tamakoshi, Maeka Shiroyama, Ai Tsuruoka, Kyohei Saiki, Kazuhiro Takumi, Gen Nonaka, Tsuyoshi Nakanishi, Takako Hishiki …

JOURNAL OF BIOSCIENCE AND BIOENGINEERING 119(3) 310-313 2015年3月
Neutral aminoaciduria in cystathionine β-synthase-deficient mice, an animal model of homocystinuria

Akahoshi Noriyuki, Kamata Shotaro, Kubota Masashi, Hishiki Takako, Nagahata Yoshiko, Matsuura Tomomi, Yamazaki Chiho, Yoshida Yuka, Yamada Hidenori, Ishizaki Yasuki …

American Journal of Physiology - Renal Physiology 306(12) F1462-F1476 2014年6月15日査読有り
Neutral aminoaciduria in cystathionine β-synthase-deficient mice, an animal model of homocystinuria

Akahoshi Noriyuki, Kamata Shotaro, Kubota Masashi, Hishiki Takako, Nagahata Yoshiko, Matsuura Tomomi, Yamazaki Chiho, Yoshida Yuka, Yamada Hidenori, Ishizaki Yasuki …

American Journal of Physiology - Renal Physiology 306(12) F1462-F1476 2014年6月15日
Large-Area Surface-Enhanced Raman Spectroscopy Imaging of Brain Ischemia by Gold Nanoparticles Grown on Random Nanoarrays of Transparent Boehmite

Shogo Yamazoe, Masayuki Naya, Megumi Shiota, Takayuki Morikawa, Akiko Kubo, Takeharu Tani, Takako Hishiki, Tadashi Horiuchi, Makoto Suematsu, Mayumi Kajimura

ACS NANO 8(6) 5622-5632 2014年6月
Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Takehiro Yamamoto, Naoharu Takano, Kyoko Ishiwata, Mitsuyo Ohmura, Yoshiko Nagahata, Tomomi Matsuura, Aki Kamata, Kyoko Sakamoto, Tsuyoshi Nakanishi, Akiko Kubo …

NATURE COMMUNICATIONS 5 2014年3月
A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting

Mas Rizky A. A. Syamsunarno, Tatsuya Iso, Hirofumi Hanaoka, Aiko Yamaguchi, Masaru Obokata, Norimichi Koitabashi, Kosaku Goto, Takako Hishiki, Yoshiko Nagahata, Hiroki Matsui …

PLoS ONE 8(11) 2013年11月14日
Capillary Endothelial Fatty Acid Binding Proteins 4 and 5 Play a Critical Role in Fatty Acid Uptake in Heart and Skeletal Muscle

Tatsuya Iso, Kazuhisa Maeda, Hirofumi Hanaoka, Toshihiro Suga, Kosaku Goto, Mas Rizky A. A. Syamsunarno, Takako Hishiki, Yoshiko Nagahata, Hiroki Matsui, Masashi Arai …

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 33(11) 2549-2557 2013年11月
Energy Management by Enhanced Glycolysis in G(1)-phase in Human Colon Cancer Cells In Vitro and In Vivo

Yan Bao, Kuniaki Mukai, Takako Hishiki, Akiko Kubo, Mitsuyo Ohmura, Yuki Sugiura, Tomomi Matsuura, Yoshiko Nagahata, Noriyo Hayakawa, Takehiro Yamamoto …

MOLECULAR CANCER RESEARCH 11(9) 973-985 2013年9月
Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes.

Shugo Tohyama, Fumiyuki Hattori, Motoaki Sano, Takako Hishiki, Yoshiko Nagahata, Tomomi Matsuura, Hisayuki Hashimoto, Tomoyuki Suzuki, Hiromi Yamashita, Yusuke Satoh …

Cell stem cell 12(1) 127-37 2013年1月3日
Gas biology: Tiny molecules controlling metabolic systems

Mayumi Kajimura, Tsuyoshi Nakanishi, Toshiki Takenouchi, Takayuki Morikawa, Takako Hishiki, Yoshinori Yukutake, Makoto Suematsu

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 184(2) 139-148 2012年11月
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

Imaizumi Yoichi, Okada Yohei, Akamatsu Wado, Koike Masato, Kuzumaki Naoko, Hayakawa Hideki, Nihira Tomoko, Kobayashi Tetsuro, Ohyama Manabu, Sato Shigeto …

Molecular Brain 5(1) 2012年10月
Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria

Yamada Hidenori, Akahoshi Noriyuki, Kamata Shotaro, Hagiya Yoshifumi, Hishiki Takako, Nagahata Yoshiko, Matsuura Tomomi, Takano Naoharu, Mori Masatomo, Ishizaki Yasuki …

Free Radical Biology and Medicine 52(9) 1716-1726 2012年5月

もっとみる

担当経験のある科目(授業)

2022年4月 - 2023年3月

医化学 (慶應義塾)
2021年4月 - 2022年3月

医化学 (慶應義塾)
2020年4月 - 2021年3月

医化学 (慶應義塾)
2019年4月 - 2020年3月

医化学 (慶應義塾)
2015年4月 - 2016年3月

医化学実習 (慶應義塾)
2015年4月 - 2016年3月

医化学 (慶應義塾)
医化学実習 (慶應義塾)

共同研究・競争的資金等の研究課題

表面増強ラマンイメージングによるポリスルフィドを標的とした新規膵癌治療法の開発

基盤研究(C) 2024年4月 - 2027年3月

菱木貴子
表面増強ラマンイメージングを用いた薬剤耐性がんにおけるポリスルフィドの機能解明

文部科学省・日本学術振興会科学研究費助成事業基盤研究(C) 2021年4月 - 2024年3月

菱木貴子
新規質量分析イメージングによるパースルフィド依存性虚血再灌流障害制御機構の解明

文部科学省・日本学術振興会科学研究費助成事業基盤研究(C) 2016年4月 - 2019年3月

菱木貴子