論文

査読有り 国際誌
2022年12月14日

Effects of cerebellar transcranial direct current stimulation on upper limb motor function after stroke: study protocol for the pilot of a randomized controlled trial.

Pilot and feasibility studies
  • Akiko Yuasa
  • ,
  • Shintaro Uehara
  • ,
  • Kazuki Ushizawa
  • ,
  • Takamichi Toyama
  • ,
  • Jose Gomez-Tames
  • ,
  • Akimasa Hirata
  • ,
  • Yohei Otaka

8
1
開始ページ
259
終了ページ
259
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s40814-022-01223-9

BACKGROUND: Transcranial direct current stimulation (tDCS) is a technique that can noninvasively modulate neural states in a targeted brain region. As cerebellar activity levels are associated with upper limb motor improvement after stroke, the cerebellum is a plausible target of tDCS. However, the effect of tDCS remains unclear. Here, we designed a pilot study to assess: (1) the feasibility of a study that aims to examine the effects of cerebellar tDCS combined with an intensive rehabilitation approach based on the concept of constraint-induced movement therapy (CIMT) and (2) the preliminary outcome of the combined approach on upper limb motor function in patients with stroke in the chronic stage. METHODS: This pilot study has a double-blind randomized controlled design. Twenty-four chronic stroke patients with mild to moderate levels of upper limb motor impairment will be randomly assigned to an active or sham tDCS group. The participants will receive 20 min of active or sham tDCS to the contralesional cerebellum at the commencement of 4 h of daily intensive training, repeatedly for 5 days per week for 2 weeks. The primary outcomes are recruitment, enrollment, protocol adherence, and retention rates and measures to evaluate the feasibility of the study. The secondary outcome is upper limb motor function which will be evaluated using the Action Research Arm Test, Fugl-Meyer Assessment, for the upper extremity and the Motor Activity Log. Additionally, neurophysiological and neuroanatomical assessments of the cerebellum will be performed using transcranial magnetic stimulation and magnetic resonance imaging. These assessments will be conducted before, at the middle, and after the 2-week intervention, and finally, 1 month after the intervention. Any adverse events that occur during the study will be recorded. DISCUSSION: Cerebellar tDCS combined with intensive upper limb training may increase the gains of motor improvement when compared to the sham condition. The present study should provide valuable evidence regarding the feasibility of the design and the efficacy of cerebellar tDCS for upper limb motor function in patients with stroke before a future large trial is conducted. TRIAL REGISTRATION: This study has been registered at the Japan Registry of Clinical Trials ( jRCTs042200078 ). Registered 17 December 2020.

リンク情報
DOI
https://doi.org/10.1186/s40814-022-01223-9
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/36517911
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748387
ID情報
  • DOI : 10.1186/s40814-022-01223-9
  • PubMed ID : 36517911
  • PubMed Central 記事ID : PMC9748387

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