2018年5月11日
School-age children and adolescents suspected of having been to be infected with pertussis in Japan
Vaccine
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 36
- 号
- 20
- 開始ページ
- 2910
- 終了ページ
- 2915
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.vaccine.2018.01.048
- 出版者・発行元
- Elsevier Ltd
Many countries including Japan have adapted acellular pertussis vaccines combined with diphtheria and tetanus toxoids (DTaP). DTaP vaccine coverage is approximately >
90%, but pertussis re-emergence has been observed since 2000 in Japan. In the present study, anti-pertussis antibodies were investigated among school-age children and adolescents from 2013 to 2015. The positive rate of anti-pertussis toxin (PT) antibodies was higher among children aged 12–13 years (60.0%. 95%CI
56.0–63.9%) in 2014 and 18–19 years (73.0%. 95%CI
61.4–82.6%) in 2013, compared with 6–7 years (47.1%. 95%CI
40.7–53.6%). The mean PT antibody titer was higher among children aged 12–13 years (23.8 EU/ml. 95%CI
21.9–25.8) in 2014 and 18–19 years (29.3 EU/ml. 95%CI
23.0–35.6) in 2013, compared with 6–7 years (18.3 EU/ml. 95%CI
15.5–21.2). Distributions of pertussis antibodies and mean titers at their same grade of school-age were similar from 2013 to 2015. Although school-age children were immunized with 4 doses of DTaP, the data suggested the decay of vaccine-acquired immunity and possibility of asymptomatic infection in school age, indicating the additional DTaP vaccination before the entry of elementary school, preventing household contact.
90%, but pertussis re-emergence has been observed since 2000 in Japan. In the present study, anti-pertussis antibodies were investigated among school-age children and adolescents from 2013 to 2015. The positive rate of anti-pertussis toxin (PT) antibodies was higher among children aged 12–13 years (60.0%. 95%CI
56.0–63.9%) in 2014 and 18–19 years (73.0%. 95%CI
61.4–82.6%) in 2013, compared with 6–7 years (47.1%. 95%CI
40.7–53.6%). The mean PT antibody titer was higher among children aged 12–13 years (23.8 EU/ml. 95%CI
21.9–25.8) in 2014 and 18–19 years (29.3 EU/ml. 95%CI
23.0–35.6) in 2013, compared with 6–7 years (18.3 EU/ml. 95%CI
15.5–21.2). Distributions of pertussis antibodies and mean titers at their same grade of school-age were similar from 2013 to 2015. Although school-age children were immunized with 4 doses of DTaP, the data suggested the decay of vaccine-acquired immunity and possibility of asymptomatic infection in school age, indicating the additional DTaP vaccination before the entry of elementary school, preventing household contact.
- ID情報
-
- DOI : 10.1016/j.vaccine.2018.01.048
- ISSN : 1873-2518
- ISSN : 0264-410X
- SCOPUS ID : 85046417314