2020年11月1日
Experimental techniques for the development of a uterus transplantation model in cynomolgus macaques
Journal of Obstetrics and Gynaecology Research
- 巻
- 46
- 号
- 11
- 開始ページ
- 2251
- 終了ページ
- 2260
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/jog.14477
- 出版者・発行元
- Journal of Obstetrics and Gynaecology Research
Uterus transplantation (UTx) is now a treatment for women with uterine factor infertility to have a child. However, UTx is still largely at the experimental stage, and many medical issues remain unsolved. Therefore, adequate studies in large animals including non-human primates are required for validation of these issues. UTx research, especially in non-human primates, can provide important information for its full establishment in humans due to the anatomical and physiological similarities between the two. We accumulated data from UTx studies using cynomolgus macaques since 2009 and established autologous and allogeneic UTx models which led to deliveries after performing the procedure. In this paper, we summarized key points to develop UTx models in cynomolgus macaques based on our experience. UTx models in non-human primates can surely contribute new and beneficial knowledge in this field and can be useful for the further development of UTx in humans.
- リンク情報
- ID情報
-
- DOI : 10.1111/jog.14477
- ISSN : 1341-8076
- PubMed ID : 32924267