MISC

2001年8月

NeuroD/BETA2 gene G -> A polymorphism may affect onset pattern of type 1 diabetes in Japanese

DIABETES CARE
  • S Yamada
  • ,
  • Y Motohashi
  • ,
  • T Yanagawa
  • ,
  • T Maruyama
  • ,
  • A Kasuga
  • ,
  • H Hirose
  • ,
  • K Matsubara
  • ,
  • A Shimada
  • ,
  • T Saruta

24
8
開始ページ
1438
終了ページ
1441
記述言語
英語
掲載種別
出版者・発行元
AMER DIABETES ASSOC

OBJECTIVE - The majority of type I diabetes is considered to be autoimmune with, for the most part, abrupt development. However, type I diabetes with slow onset, or the so-called slowly progressive type I diabetes or latent autoimmune diabetes in adults, has been recently recognized and is considered to be autoimmune-related. Although some investigators tried to explain the difference in onset pattern by the genetic background, including HLA type, it has not been established thus far. We hypothesized that the difference in onset pattern may relate to regeneration or differentiation of pancreatic beta -cells, and we therefore focused on the NeuroD/BETA2 gene, which encodes a transcription factor for the insulin gene and P-cell differentiation.
RESEARCH DESIGN AND METHODS - We examined the NeuroD/BETA2 gene polymorphism in 105 Japanese type I diabetic patients and in 122 nondiabetic Japanese subjects in a case-control study, and we stratified the patients according to their onset pattern and islet-associated autoantibody positivity.
RESULTS - Regardless of the existence of islet-associated autoantibody, we found a significant difference in A allele frequency between type I diabetic patients with acute-onset type and control subjects. However, no difference was found between type I slow-onset diabetic Patients and control subjects.
CONCLUSIONS - These results support our hypothesis that NeuroD/BETA2 may affect the ability of regeneration of beta -cells, leading to a difference in the onset pattern and clinical course of type 1 diabetes.

Web of Science ® 被引用回数 : 21

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000170076400022&DestApp=WOS_CPL
ID情報
  • ISSN : 0149-5992
  • Web of Science ID : WOS:000170076400022

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