MISC

1996年7月

HLA class II is associated with the frequency of glutamic acid decarboxylase M, 65 000 autoantibodies in Japanese patients with insulin-dependent diabetes mellitus

ACTA DIABETOLOGICA
  • A Kasuga
  • ,
  • A Falorni
  • ,
  • T Maruyama
  • ,
  • Y Ozawa
  • ,
  • CE Grubin
  • ,
  • K Matsubara
  • ,
  • Takei, I
  • ,
  • T Saruta
  • ,
  • A Scheynius
  • ,
  • A Lernmark

33
2
開始ページ
108
終了ページ
113
記述言語
英語
掲載種別
DOI
10.1007/s005920050016
出版者・発行元
SPRINGER VERLAG

Autoantibodies to glutamic acid decarboxylase (GAD65Ab) are common in both caucasian and Japanese patients with insulin-dependent diabetes mellitus (type 1), while the type 1-associated HLA haplotypes differ. In the present study, we analyzed GAD65Ab in relation to HLA-DQ and -DR alleles in Japanese type 1 patients. GAD65Ab were found in 58% short-duration (less than 5 years) type 1, 23% long-duration type 1, 56% slowly progressive type 1, 3% type 2 patients, and 1.7% healthy individuals. In 75 HLA-typed type 1 patients, the GAD65Ab frequency was higher in short-duration patients with DRB1*08 allele (100%, Pc<0.05). GAD65Ab frequencies in DQB1*0302, DQB1*0303, and DRB1*09-positive, long-duration type I patients were lower than those in short-duration type I patients (14%, 19%, and 20%, Pc<0.02 compared with short-duration type 1, 90%, 75%, and 71%, respectively), while the frequency varied less in DQB1*04 individuals (44% and 30% in short- and long-duration type 1 patients, respectively). These findings were also observed among patients with DRB1*04, i.e., the haplotype DRB1*0405-DQB1*0401 showed less variation in frequency of GAD65Ab (44% and 35% in short- and long-duration type 1 patients, respectively), while DRB1*04xx-DQB1*0302 showed lower frequency in long-duration type 1 than short-duration (13% and 100%, respectively). Thus, HLA class II is associated with frequency GAD65Ab, and this association might be affected by disease duration in Japanese type 1 patients.

Web of Science ® 被引用回数 : 9

リンク情報
DOI
https://doi.org/10.1007/s005920050016
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1996VQ17300004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s005920050016
  • ISSN : 0940-5429
  • Web of Science ID : WOS:A1996VQ17300004

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